DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and ctsh

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_997853.1	Gene:	ctsh / 324818	ZFINID:	ZDB-GENE-030131-3539	Length:	330	Species:	Danio rerio

Alignment Length:	307	Identity:	109/307 - (35%)
Similarity:	167/307 - (54%)	Gaps:	19/307 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 DHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGSAKY--GITEFADMTSSEYKE 367
            ::.|..:..::.::| ...|...||:||.:|.|.|::.|.   |:.|:  |:.:|:|||.:|:|:
Zfish    27 EYHFKSWMSQYNKKY-EINEFYQRLQIFLENKKRIDQHNE---GNHKFSMGLNQFSDMTFAEFKK 87

  Fly   368 RTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQK-DAVTQVKNQGSCGSCWAFSVTGNIEGLY 431
            ...|.:.....||.|:..   :.:|..|...|||.| ..:|.|||||.|||||.||.||.:|.:.
Zfish    88 TYLLTEPQNCSATRGNHV---SSNGLYPDAIDWRTKGHYITDVKNQGPCGSCWTFSTTGCLESVT 149

  Fly   432 AVKTGELKEFSEQELLDC--DTTDSACNGGLMDNAYKAIKDIGGLEYEAEYPYKAKKNQCHFNRT 494
            |:.||:|.:.:||:|:||  |..:..|||||..:|::.|....||..|.:|||:||..||.|...
Zfish   150 AIATGKLLQLAEQQLIDCAGDFDNHGCNGGLPSHAFEYIMYNKGLMTEDDYPYQAKGGQCRFKPQ 214

  Fly   495 LSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANA-MQFYRGGVSHPWKALCSKKNLDHGVL 558
            |:...|...|::.|.:|..|.:.:....|:|......: ...|:.|:....:...:...::|.||
Zfish   215 LAAAFVKEVVNITKYDEMGMVDAVARLNPVSFAYEVTSDFMHYKDGIYTSTECHNTTDMVNHAVL 279

  Fly   559 VVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVS 605
            .|||...:      ..||||||||||..||.:||:.:.||.|.||::
Zfish   280 AVGYAEEN------GTPYWIVKNSWGTNWGIKGYFYIERGKNMCGLA 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	18/58 (31%)
		Peptidase_C1A	395..611	CDD:239068	84/215 (39%)
ctsh	NP_997853.1	Inhibitor_I29	30..85	CDD:285458	18/58 (31%)
ctsh	NP_997853.1	Peptidase_C1	112..327	CDD:278538	84/215 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810