DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and ctslb

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_571273.2	Gene:	ctslb / 30443	ZFINID:	ZDB-GENE-980526-285	Length:	352	Species:	Danio rerio

Alignment Length:	320	Identity:	120/320 - (37%)
Similarity:	186/320 - (58%)	Gaps:	23/320 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 KVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELN-----ANEMGSAKYGITEFADMTS 362
            ::|..:..::.:.|:.|....|...|: |:.:||:.||:.|     .|.  :.|.|:.:|.|||:
Zfish    39 QLDDHWNSWKSQHGKSYHEDVEVGRRM-IWEENLRKIEQHNFEYSYGNH--TFKMGMNQFGDMTN 100

  Fly   363 SEYKERTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGSCWAFSVTGNI 427
            .|:::....:..|..:.:.|...:.|::.. .|::.||||:..||.||:|..|||||:||.||.:
Zfish   101 EEFRQAMNGYTHDPNQTSQGPLFMEPSFFA-APQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGAL 164

  Fly   428 EGLYAVKTGELKEFSEQELLDCDTT--DSACNGGLMDNAYKAIKDIGGLEYEAEYPYKAKKN-QC 489
            ||....|||:|...|||.|:||...  :..|||||||.|::.:|:..||:.|..|||.|:.: .|
Zfish   165 EGQLFRKTGKLISMSEQNLVDCSRPQGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPC 229

  Fly   490 HFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINAN--AMQFYRGGVSHPWKALCSKKN 552
            .::...:..::.||||:|.|||.|:...:.|.||:|:.|:|:  ::|||:.|:.  ::..||...
Zfish   230 RYDPRFNVAKITGFVDIPSGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIY--YERACSSSR 292

  Fly   553 LDHGVLVVGYGV--SDYPNFHKTLPYWIVKNSWGPRWGEQGY-YRVYRGDNTCGVSEMAT 609
            |||.|||||||.  :|.....    ||||||||..:||::|| |.....:|.|||:..|:
Zfish   293 LDHAVLVVGYGYQGADVAGNR----YWIVKNSWSDKWGDKGYIYMAKDKNNHCGVATKAS 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	17/61 (28%)
		Peptidase_C1A	395..611	CDD:239068	98/223 (44%)
ctslb	NP_571273.2	Inhibitor_I29	44..102	CDD:214853	17/60 (28%)
ctslb	NP_571273.2	Peptidase_C1	131..351	CDD:306594	98/224 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.710