DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Ctsw

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001019413.1	Gene:	Ctsw / 293676	RGDID:	1309354	Length:	371	Species:	Rattus norvegicus

Alignment Length:	324	Identity:	113/324 - (34%)
Similarity:	182/324 - (56%)	Gaps:	17/324 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 KVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGSAKYGITEFADMTSSEYKE 367
            ::..:|..||::|.|.|.:.||...||.||..||...:.|...::|:|::|.|.|:|:|..|:.:
  Rat    35 ELKEVFKLFQIQFNRSYSNPAEYTRRLGIFAHNLAQAQRLQEEDLGTAEFGQTPFSDLTEEEFGQ 99

  Fly   368 RTGLWQRDEAKATGGSAAVVPAYHGE-LPKEFDWRQ-KDAVTQVKNQGSCGSCWAFSVTGNIEGL 430
            ..| .||...:....:..|.....|| :|...|||: |:.::.:||||:|..|||.:...||:.|
  Rat   100 LYG-HQRAPERILNMAKKVKSERWGESVPPTCDWRKVKNIISSIKNQGNCRCCWAIAAADNIQTL 163

  Fly   431 YAVKTGELKEFSEQELLDCDTTDSACNGGLMDNAYKAIKDIGGLEYEAEYPYKA--KKNQCHFNR 493
            :.:||.:..:.|.|||||||...:.||||.:.:||..:.:..||..|.:||::.  |.::|..::
  Rat   164 WRIKTQQFVDVSVQELLDCDRCGNGCNGGFVWDAYITVLNNSGLASEEDYPFQGHQKPHRCLADK 228

  Fly   494 TLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANAMQFYRGGVSHPWKALCSKKNLDHGVL 558
            ......:..|..| ..||..:..:|..:|||::.||...:|:|:.||.....:.|....::|.||
  Rat   229 YRKVAWIQDFTML-SSNEQVIAGYLAIHGPITVTINMKLLQYYQKGVIKATPSTCDPHLVNHSVL 292

  Fly   559 VVGYG-----------VSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMATSA 611
            :||:|           :|......::.||||:|||||..|||:||:|:|||:||||:::...:|
  Rat   293 LVGFGKEKGGMQTGTLLSHSRKPRRSTPYWILKNSWGAEWGEKGYFRLYRGNNTCGIAKYPITA 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	22/56 (39%)
		Peptidase_C1A	395..611	CDD:239068	83/229 (36%)
Ctsw	NP_001019413.1	Inhibitor_I29	40..96	CDD:214853	22/55 (40%)
Ctsw	NP_001019413.1	Peptidase_C1	126..356	CDD:278538	83/230 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11292
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920