DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Ctsj

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_058817.1	Gene:	Ctsj / 29174	RGDID:	69241	Length:	334	Species:	Rattus norvegicus

Alignment Length:	346	Identity:	114/346 - (32%)
Similarity:	168/346 - (48%)	Gaps:	67/346 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 EWAEKKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGSAK 351
            ||.:.||                    ::.:.| |..|.:::..::.:|||.| :|:..|.|..|
  Rat    28 EWQDWKT--------------------KYAKSY-SPVEEELKRAVWEENLKMI-QLHNKENGLGK 70

  Fly   352 YGIT----EFADMTSSEYKERTGLWQRDEAKATGGSAAVVPAYHGE----------LPKEFDWRQ 402
            .|.|    .|||.|..|:::..             |..::||....          ||...|||:
  Rat    71 NGFTMEMNAFADTTGEEFRKSL-------------SDILIPAAVTNPSAQKQVSIGLPNFKDWRK 122

  Fly   403 KDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTTD--SACNGGLMDNAY 465
            :..||.|:|||.|||||||:..|.|||....|||.|...|.|.||||..::  :.|..|....|:
  Rat   123 EGYVTPVRNQGKCGSCWAFAAVGAIEGQMFSKTGNLTPLSVQNLLDCSKSEGNNGCRWGTAHQAF 187

  Fly   466 KAIKDIGGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINA 530
            ..:....|||.||.|||:.|...|.::...:...:.|||:||. ||..:...:.:.||:|..|:|
  Rat   188 NYVLKNKGLEAEATYPYEGKDGPCRYHSENASANITGFVNLPP-NELYLWVAVASIGPVSAAIDA 251

  Fly   531 --NAMQFYRGGVSHPWKALCSKKNLDHGVLVVGYGV----SDYPNFHKTLPYWIVKNSWGPRWGE 589
              ::.:||.|||.|  :..||...::|.|||||||.    :|..|      ||::|||||..||.
  Rat   252 SHDSFRFYSGGVYH--EPNCSSYVVNHAVLVVGYGFEGNETDGNN------YWLIKNSWGEEWGI 308

  Fly   590 QGYYRVYRG-DNTCGVSEMAT 609
            .|:.::.:. :|.||::..|:
  Rat   309 NGFMKIAKDRNNHCGIASQAS 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	17/60 (28%)
		Peptidase_C1A	395..611	CDD:239068	88/224 (39%)
Ctsj	NP_058817.1	PTZ00203	4..319	CDD:185513	110/334 (33%)
		Inhibitor_I29	29..87	CDD:214853	20/79 (25%)
		Peptidase_C1	114..331	CDD:278538	89/225 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810