DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Cts7

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001099569.1	Gene:	Cts7 / 290970	RGDID:	1309226	Length:	331	Species:	Rattus norvegicus

Alignment Length:	340	Identity:	114/340 - (33%)
Similarity:	177/340 - (52%)	Gaps:	39/340 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 HTRSVEWAEKKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIE---ELN 343
            ::...||.|.|.:...::                     |..|.:.|..::.:|:|.|:   ..|
  Rat    23 YSLDAEWEEWKRNNAKTY---------------------SPEEEKQRRAVWEENVKMIKWHTMQN 66

  Fly   344 ANEMGSAKYGITEFADMTSSEYKERTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVTQ 408
            ...|.:....:.||.|||..|.:..|     |.:..|..:...:...:.::||..|||....|..
  Rat    67 GLWMNNFTIEMNEFGDMTGEEMRMMT-----DSSALTLRNGKHIQKRNVKIPKTLDWRDTGCVAP 126

  Fly   409 VKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTT--DSACNGGLMDNAYKAIKDI 471
            |::||.||:||||||..:||.....|||:|...|.|.|:||..|  ::.|:||....|::.:|:.
  Rat   127 VRSQGGCGACWAFSVAASIESQLFKKTGKLIPLSVQNLIDCTVTYGNNDCSGGKPYTAFQYVKNN 191

  Fly   472 GGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANAMQF- 535
            ||||.||.|||:||...|.:....|.|::|.|..:|: ||.|:.:.|:..|||::.|:.:...|
  Rat   192 GGLEAEATYPYEAKLRHCRYRPERSVVKIARFFVVPR-NEEALMQALVTYGPIAVAIDGSHASFK 255

  Fly   536 -YRGGVSHPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGD 599
             ||||:.|..|  |.:..||||:|:||||...:.:.::  .||::|||.|.:|||:||.::.|..
  Rat   256 RYRGGIYHEPK--CRRDTLDHGLLLVGYGYEGHESENR--KYWLLKNSHGEQWGERGYMKLPRDQ 316

  Fly   600 NT-CGVSEMATSAVL 613
            |. ||::..|...:|
  Rat   317 NNYCGIASYAMYPLL 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	13/59 (22%)
		Peptidase_C1A	395..611	CDD:239068	92/220 (42%)
Cts7	NP_001099569.1	PTZ00203	3..325	CDD:185513	112/332 (34%)
		Inhibitor_I29	29..87	CDD:214853	16/78 (21%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q91ZF2	33..50		4/37 (11%)
		Peptidase_C1A	113..329	CDD:239068	92/220 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710