DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and TINAG

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_055279.3	Gene:	TINAG / 27283	HGNCID:	14599	Length:	476	Species:	Homo sapiens

Alignment Length:	330	Identity:	78/330 - (23%)
Similarity:	128/330 - (38%)	Gaps:	81/330 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 IEELNANEMGSAKYGITEFADMTSSE-YKERTG-------LWQRDEAKATGGSAAVVPAY----- 390
            ||::|..:.|......::|..||..: :|.|.|       |...:|..|:..:...:|.:
Human   161 IEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASY 225

  Fly   391 ------HGELPKEFDWRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVK-----TGELKEFSEQ 444
                  ||.|                :|.:|.:.||||.........|::     |..|   |.|
Human   226 KWPGWTHGPL----------------DQKNCAASWAFSTASVAADRIAIQSKGRYTANL---SPQ 271

  Fly   445 ELLDCDTTD-SACNGGLMDNAYKAIKDIGGLEYEAEYP----YKAKKNQC------------HFN 492
            .|:.|...: ..||.|.:|.|:..::. .||...|.||    ..|..|.|            |..
Human   272 NLISCCAKNRHGCNSGSIDRAWWYLRK-RGLVSHACYPLFKDQNATNNGCAMASRSDGRGKRHAT 335

  Fly   493 RTL-SHVQVAGFV---DLP---KGNETAMQEWLLANGPISIGINANAMQF-YRGGVSHPWKALCS 549
            :.. ::|:.:..:   ..|   ..|||.:.:.::.|||:...:......| |:.|:   ::.:.|
Human   336 KPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAIMQVREDFFHYKTGI---YRHVTS 397

  Fly   550 --------KKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSE 606
                    :|...|.|.:.|:|........|. .:||..||||..|||.||:|:.||.|...:.:
Human   398 TNKESEKYRKLQTHAVKLTGWGTLRGAQGQKE-KFWIAANSWGKSWGENGYFRILRGVNESDIEK 461

  Fly   607 MATSA 611
            :..:|
Human   462 LIIAA 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	7/26 (27%)
		Peptidase_C1A	395..611	CDD:239068	60/253 (24%)
TINAG	NP_055279.3	Somatomedin_B	61..104	CDD:279385
		VWC	120..>154	CDD:302663
		Peptidase_C1A_CathepsinB	218..466	CDD:239111	64/271 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910