DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Ctsl

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_037288.1	Gene:	Ctsl / 25697	RGDID:	2448	Length:	334	Species:	Rattus norvegicus

Alignment Length:	342	Identity:	128/342 - (37%)
Similarity:	189/342 - (55%)	Gaps:	43/342 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 TRSVEWAE-KKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANE 346
            |.:.:|.: |.||                      ||...|.|.:.|..::.:|::.| :|:..|
  Rat    24 TFNAQWHQWKSTH----------------------RRLYGTNEEEWRRAVWEKNMRMI-QLHNGE 65

  Fly   347 MGSAKYGIT----EFADMTSSEYKERTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVT 407
            ..:.|:|.|    .|.|||:.|:::....::..:.|.  |.....|... ::||..|||:|..||
  Rat    66 YSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRHQKHKK--GRLFQEPLML-QIPKTVDWREKGCVT 127

  Fly   408 QVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDC--DTTDSACNGGLMDNAYKAIKD 470
            .|||||.||||||||.:|.:||...:|||:|...|||.|:||  |..:..|||||||.|::.||:
  Rat   128 PVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKE 192

  Fly   471 IGGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINAN--AM 533
            .|||:.|..|||:||...|.:....:.....||||:|: .|.|:.:.:...||||:.::|:  ::
  Rat   193 NGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQ-QEKALMKPVATVGPISVAMDASHPSL 256

  Fly   534 QFYRGGVSHPWKALCSKKNLDHGVLVVGYGVSDY-PNFHKTLPYWIVKNSWGPRWGEQGYYRVYR 597
            |||..|:.  ::..||.|:|||||||||||.... .|..|   ||:||||||..||..||.::.:
  Rat   257 QFYSSGIY--YEPNCSSKDLDHGVLVVGYGYEGTDSNKDK---YWLVKNSWGKEWGMDGYIKIAK 316

  Fly   598 G-DNTCGVSEMATSAVL 613
            . :|.||::..|:..::
  Rat   317 DRNNHCGLATAASYPIV 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	16/60 (27%)
		Peptidase_C1A	395..611	CDD:239068	103/221 (47%)
Ctsl	NP_037288.1	Inhibitor_I29	29..87	CDD:214853	20/80 (25%)
Ctsl	NP_037288.1	Peptidase_C1	114..332	CDD:278538	103/223 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343573
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.640