DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Ctsh

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_037071.1	Gene:	Ctsh / 25425	RGDID:	2447	Length:	333	Species:	Rattus norvegicus

Alignment Length:	296	Identity:	102/296 - (34%)
Similarity:	149/296 - (50%)	Gaps:	20/296 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 STAERQMRLRIFRQNLKTIEELNANEMGSAKYGITEFADMTSSEYKERTGLWQRDEAKATGGSAA 385
            |:.|...||::|..|.:.|:..|... .:.|.|:.:|:||:.:|.|.:. ||...:     ..:|
  Rat    45 SSREYSHRLQVFANNWRKIQAHNQRN-HTFKMGLNQFSDMSFAEIKHKY-LWSEPQ-----NCSA 102

  Fly   386 VVPAY---HGELPKEFDWRQK-DAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQEL 446
            ....|   .|..|...|||:| :.|:.|||||:|||||.||.||.:|...|:.:|::...:||:|
  Rat   103 TKSNYLRGTGPYPSSMDWRKKGNVVSPVKNQGACGSCWTFSTTGALESAVAIASGKMMTLAEQQL 167

  Fly   447 LDC--DTTDSACNGGLMDNAYKAIKDIGGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKG 509
            :||  :..:..|.|||...|::.|....|:..|..|||..|..||.||...:...|...|::...
  Rat   168 VDCAQNFNNHGCQGGLPSQAFEYILYNKGIMGEDSYPYIGKNGQCKFNPEKAVAFVKNVVNITLN 232

  Fly   510 NETAMQEWLLANGPISIGINANA-MQFYRGGVSHPWKALCSKKNLDHGVLVVGYGVSDYPNFHKT 573
            :|.||.|.:....|:|....... ...|:.||........:...::|.||.||||..:      .
  Rat   233 DEAAMVEAVALYNPVSFAFEVTEDFMMYKSGVYSSNSCHKTPDKVNHAVLAVGYGEQN------G 291

  Fly   574 LPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMAT 609
            |.|||||||||..||..||:.:.||.|.||::..|:
  Rat   292 LLYWIVKNSWGSNWGNNGYFLIERGKNMCGLAACAS 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	13/43 (30%)
		Peptidase_C1A	395..611	CDD:239068	82/219 (37%)
Ctsh	NP_037071.1	Inhibitor_I29	33..88	CDD:400519	13/43 (30%)
Ctsh	NP_037071.1	Peptidase_C1	115..330	CDD:395062	82/219 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810