DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12163 and Ctsc

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_058793.1	Gene:	Ctsc / 25423	RGDID:	2445	Length:	462	Species:	Rattus norvegicus

Alignment Length:	439	Identity:	113/439 - (25%)
Similarity:	185/439 - (42%)	Gaps:	128/439 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 VQARHTRS------VEWAEKKT--H-KKHSHRFDKVDH----------------------LFYKF 311
            |..||.||      :|..|:|.  | ||....:|:|.:                      .|:|:
  Rat    43 VGPRHPRSHINCSVMEPTEEKVVIHLKKLDTAYDEVGNSGYFTLIYNQGFEIVLNDYKWFAFFKY 107

  Fly   312 QVR-------------------FGRR----------------YVSTA-----ERQMRLRIFRQNL 336
            :|:                   .||.                ||:.|     :.:...|::..|.
  Rat   108 EVKGSRAISYCHETMTGWVHDVLGRNWACFVGKKMANHSEKVYVNVAHLGGLQEKYSERLYSHNH 172

  Fly   337 KTIEELNANEMGSAKYGITEFADMTSSEYKERTGLWQRDEAKATGGSAAVV---PAYHGE----- 393
            ..::.:|:.:           ...|::.|:|...|..||..:.:|.|..::   ||...:
  Rat   173 NFVKAINSVQ-----------KSWTATTYEEYEKLSIRDLIRRSGHSGRILRPKPAPITDEIQQQ 226

  Fly   394 ---LPKEFDWRQK---DAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKE--FSEQELLDCD 450
               ||:.:|||..   :.|:.|:||.|||||::|:..|.:|....:.|...:.  .|.||::.|.
  Rat   227 ILSLPESWDWRNVRGINFVSPVRNQESCGSCYSFASLGMLEARIRILTNNSQTPILSPQEVVSCS 291

  Fly   451 TTDSACNGG---LMDNAYKAIKDIGGLEYEAEYPYKA------KKNQCHFNRTLSHVQVAGFVDL 506
            .....|:||   |:  |.|..:|.|.:| |..:||.|      .|..|....:..:..|.||..
  Rat   292 PYAQGCDGGFPYLI--AGKYAQDFGVVE-ENCFPYTATDAPCKPKENCLRYYSSEYYYVGGFYG- 352

  Fly   507 PKG-NETAMQEWLLANGPISIG--INANAMQFYRG-----GVSHPWKALCSKKNLDHGVLVVGYG 563
              | ||..|:..|:.:||:::.  ::.:.:.::.|     |:|.|:...   :..:|.||:||||
  Rat   353 --GCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPF---ELTNHAVLLVGYG 412

  Fly   564 VSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMATSAV 612
            ......    |.|||||||||.:|||.||:|:.||.:.|.:..:|.:|:
  Rat   413 KDPVTG----LDYWIVKNSWGSQWGESGYFRIRRGTDECAIESIAMAAI 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	12/96 (13%)
		Peptidase_C1A	395..611	CDD:239068	77/237 (32%)
Ctsc	NP_058793.1	CathepsinC_exc	25..138	CDD:400909	18/94 (19%)
		Pox_I6	168..>204	CDD:333259	8/46 (17%)
		Peptidase_C1A_CathepsinC	230..459	CDD:239112	79/241 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810