DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Ctsq

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_640355.1	Gene:	Ctsq / 246147	RGDID:	631421	Length:	343	Species:	Rattus norvegicus

Alignment Length:	329	Identity:	117/329 - (35%)
Similarity:	178/329 - (54%)	Gaps:	39/329 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 VDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELN-ANEMGSAKY--GITEFADMTSSEY 365
            :|..:.::::::.:.| |..|..::..::.:|:|.||..| .|.:|...|  .|.:|||||..|:
  Rat    25 LDVQWQEWKIKYEKLY-SPEEEVLKRVVWEENVKKIELHNRENSLGKNTYTMEINDFADMTDEEF 88

  Fly   366 KE------------RTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGSC 418
            |:            ...||:|    |.|........:...|||..|||.:..||:|:.||.|.||
  Rat    89 KDMIIGFQLPVHNTEKRLWKR----ALGSFFPNSWNWRDALPKFVDWRNEGYVTRVRKQGGCSSC 149

  Fly   419 WAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTT--DSACNGGLMDNAYKAIKDIGGLEYEAEYP 481
            |||.|||.|||....|||:|...|.|.|:||...  :..|..|...||::.:...||||.||.||
  Rat   150 WAFPVTGAIEGQMFKKTGKLIPLSVQNLIDCSKPQGNRGCLWGNTYNAFQYVLHNGGLEAEATYP 214

  Fly   482 YKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGIN--ANAMQFYRGGVSHPW 544
            |:.|:..|.:|...|..::.|||.||: :|..:.:.:...|||:.|::  :::.:||:.||.|..
  Rat   215 YERKEGVCRYNPKNSSAKITGFVVLPE-SEDVLMDAVATKGPIATGVHVISSSFRFYQKGVYHEP 278

  Fly   545 KALCSKKNLDHGVLVVGYGV----SDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRG-DNTCGV 604
            |  || ..::|.|||||||.    :|..|      ||::|||||.|||.:||.::.:. :|.|.:
  Rat   279 K--CS-SYVNHAVLVVGYGFEGNETDGNN------YWLIKNSWGKRWGLRGYMKIAKDRNNHCAI 334

  Fly   605 SEMA 608
            :.:|
  Rat   335 ASLA 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	17/59 (29%)
		Peptidase_C1A	395..611	CDD:239068	91/223 (41%)
Ctsq	NP_640355.1	PTZ00203	4..341	CDD:185513	117/329 (36%)
		Inhibitor_I29	29..87	CDD:214853	17/58 (29%)
		Peptidase_C1	125..342	CDD:278538	92/224 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810