DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Y51A2D.8

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_507627.1	Gene:	Y51A2D.8 / 180208	WormBaseID:	WBGene00013076	Length:	386	Species:	Caenorhabditis elegans

Alignment Length:	358	Identity:	102/358 - (28%)
Similarity:	165/358 - (46%)	Gaps:	50/358 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 EWAEKKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGS-- 349
            |:.|....:.|..:..|.   |..|:.::.|:|...:|.|.|...|.::...:::|||....:
Worm    25 EFFEINIDRDHPEKLYKA---FEDFKKKYNRKYKDESENQQRFNNFVKSYNNVDKLNAKSKAAGY 86

  Fly   350 -AKYGITEFADMTSSEYKER---------TGL--WQRDEAKATGGSAAVVPAYH----GELPKEF 398
             .::||.:|:|::::|:..|         |||  ...|:.|....:|.:....|    ...|..|
Worm    87 DTQFGINKFSDLSTAEFHGRLSNVVPSNNTGLPMLNFDKKKPDFRAADMNKTRHKRRSTRYPDYF 151

  Fly   399 DWRQKD-----AVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTTDS-ACN 457
            |.|.:.     .|..:|:||.|..||.|:||..:|.:||..:|:.|..|:||:.||.|..: .|.
Worm   152 DLRNEKINGRYIVGPIKDQGQCACCWGFAVTALVETVYAAHSGKFKSLSDQEVCDCGTEGTPGCK 216

  Fly   458 GGLMDNAYKAIKDIGGLEYEAEYPY-KAKKNQ---CHFNRTLSHVQVAGF----VDLPKGNETAM 514
            ||.:....:.:|.. ||..:.:||| :.:.||   |....|...|....|    ::..:..|..:
Worm   217 GGSLTLGVQYVKKY-GLSGDEDYPYDQNRANQGRRCRLRETDRIVPARAFNFAVINPRRAEEQII 280

  Fly   515 Q---EWLLANGPISIGINANAMQF--YRGGVSHPWKALCSKKNLDHGVLVVGYG-VSDYPNFHKT 573
            |   ||.:   |:::...... ||  |:.||.  .:..|.:....|...:|||. |.|  :..::
Worm   281 QVLTEWKV---PVAVYFKVGD-QFKEYKEGVI--IEDDCRRATQWHAGAIVGYDTVED--SRGRS 337

  Fly   574 LPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSE 606
            ..|||:|||||..|.|.||.||.||.:.|.:.:
Worm   338 HDYWIIKNSWGGDWAESGYVRVVRGRDWCSIED 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	15/59 (25%)
		Peptidase_C1A	395..611	CDD:239068	74/232 (32%)
Y51A2D.8	NP_507627.1	Inhibitor_I29	43..102	CDD:214853	15/58 (26%)
Y51A2D.8	NP_507627.1	Peptidase_C1A	148..373	CDD:239068	74/232 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910