DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12163 and cpr-4

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_504682.1	Gene:	cpr-4 / 179053	WormBaseID:	WBGene00000784	Length:	335	Species:	Caenorhabditis elegans

Alignment Length:	266	Identity:	66/266 - (24%)
Similarity:	105/266 - (39%)	Gaps:	61/266 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 LPKEFD----WRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAV-KTGELKEF--SEQELLDCDT 451
            :|..||    |....::..:::|..|||||||:........:.: ..|.:...  :|..|..|..
Worm    81 IPATFDARTQWPNCMSINNIRDQSDCGSCWAFAAAEAASDRFCIASNGAVNTLLSAEDVLSCCSN 145

  Fly   452 TDSACNGGLMDNAYKAIKDIG---GLEYEAEY---PYK------------------------AKK 486
            ....|.||...||:|.:...|   |..|||::   ||.                        |..
Worm   146 CGYGCEGGYPINAWKYLVKSGFCTGGSYEAQFGCKPYSLAPCGETVGNVTWPSCPDDGYDTPACV 210

  Fly   487 NQCHFNRTLSHVQVAGFVDLPKGNE--------TAMQEWLLANGPI--SIGINANAMQFYRGGVS 541
            |:|    |..:..||...|...|:.        :.:|..::|:||:  :..:..:..|:..|...
Worm   211 NKC----TNKNYNVAYTADKHFGSTAYAVGKKVSQIQAEIIAHGPVEAAFTVYEDFYQYKTGVYV 271

  Fly   542 HPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSE 606
            |    ...::...|.:.::|:|..:      ..|||:|.|||...|||.||:|:.||.|.||:..
Worm   272 H----TTGQELGGHAIRILGWGTDN------GTPYWLVANSWNVNWGENGYFRIIRGTNECGIEH 326

  Fly   607 MATSAV 612
            .....|
Worm   327 AVVGGV 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458
		Peptidase_C1A	395..611	CDD:239068	65/262 (25%)
cpr-4	NP_504682.1	Peptidase_C1A_CathepsinB	82..331	CDD:239111	65/262 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810