DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and W07B8.4

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_503382.1	Gene:	W07B8.4 / 178611	WormBaseID:	WBGene00021072	Length:	335	Species:	Caenorhabditis elegans

Alignment Length:	272	Identity:	67/272 - (24%)
Similarity:	115/272 - (42%)	Gaps:	69/272 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 LPKEFD----WRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAV-KTGELKE-FSEQELLDCDT- 451
            :|..:|    |.|..:|..:::|..||||||.:....|.....: ..|::.. .|.:::|.|.|
Worm    73 IPDSYDVRDHWPQCISVNNIRDQSHCGSCWAVAAAEAISDRTCIASNGDVNTLLSAEDILTCCTG 137

  Fly   452 ---TDSACNGGLMDNAYKA-IKD--IGGLEYEAEY---PYKAKKNQCHFNRTLSHV-------QV 500
               ....|.||....|::. :|:  :.|..:|::|   ||...  .|  ..|:..|       ::
Worm   138 KFNCGDGCEGGYPIQAWRYWVKNGLVTGGSFESQYGCKPYSIA--PC--GETIDGVTWPECPMKI 198

  Fly   501 AGFVDLPK------GNET-----------------------AMQEWLLANGPISIG-INANAMQF 535
            :   |.||      ||.:                       .:|..:||:||:.:| |.......
Worm   199 S---DTPKCEHHCTGNNSYPIPYDQDKHFGASAYAIGRSAKQIQTEILAHGPVEVGFIVYEDFYL 260

  Fly   536 YRGGVSHPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDN 600
            |:.|:   :..:...:...|.|.::|:||.:      ..|||:..|||...|||:||:|:.||.:
Worm   261 YKTGI---YTHVAGGELGGHAVKMLGWGVDN------GTPYWLAANSWNTVWGEKGYFRILRGVD 316

  Fly   601 TCGVSEMATSAV 612
            .||:...|.:.:
Worm   317 ECGIESAAVAGM 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458
		Peptidase_C1A	395..611	CDD:239068	67/268 (25%)
W07B8.4	NP_503382.1	Peptidase_C1A_CathepsinB	74..327	CDD:239111	67/268 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810