DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and CTSZ

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001327.2	Gene:	CTSZ / 1522	HGNCID:	2547	Length:	303	Species:	Homo sapiens

Alignment Length:	227	Identity:	77/227 - (33%)
Similarity:	106/227 - (46%)	Gaps:	36/227 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 ELPKEFDWRQKDAVTQ---VKNQ---GSCGSCWAFSVTGNIEGLYAVK-TGELKE--FSEQELLD 448
            :|||.:|||..|.|..   .:||   ..||||||.:.|..:.....:| .|....  .|.|.::|
Human    61 DLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVID 125

  Fly   449 CDTTDSACNGG----LMDNAYK-AIKDIGGLEYEAEYPYKAKKNQ---------CHFNRTLSHVQ 499
            |....| |.||    :.|.|:: .|.|.....|:|:.....|.||         ||..|..:..:
Human   126 CGNAGS-CEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWR 189

  Fly   500 VAGFVDLPKGNETAMQEWLLANGPISIGINA-NAMQFYRGGVSHPWKALCSKKNLDHGVLVVGYG 563
            |..:..| .|.|..|.| :.||||||.||.| ..:..|.||:...::   ....::|.|.|.|:|
Human   190 VGDYGSL-SGREKMMAE-IYANGPISCGIMATERLANYTGGIYAEYQ---DTTYINHVVSVAGWG 249

  Fly   564 VSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRV 595
            :||      ...||||:||||..|||:|:.|:
Human   250 ISD------GTEYWIVRNSWGEPWGERGWLRI 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458
		Peptidase_C1A	395..611	CDD:239068	76/225 (34%)
CTSZ	NP_001327.2	Peptidase_C1A_CathepsinX	62..302	CDD:239149	77/226 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810