Protein Alignment CtsF and CTSW

DIOPT Version :10

• Sequence 1: NP_730901.1
• Gene: CtsF / 40628
• FlyBaseID: FBgn0260462
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_001326.3
• Gene: CTSW / 1521
• HGNCID: 2546
• Length: 376
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 112/326 - (34%)
• Similarity: 176/326 - (53%)
• Gaps: 28/326 - (8%)

  Fly   308 FYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGSAKYGITEFADMTSSEYKERTGLW 372
            |..||::|.|.|:|..|...||.||..||...:.|...::|:|::|:|.|:|:|..|:.:..|.
Human    42 FKLFQIQFNRSYLSPEEHAHRLDIFAHNLAQAQRLQEEDLGTAEFGVTPFSDLTEEEFGQLYGY- 105

  Fly   373 QRDEAKATGGSAAVVPAYHGELPKE-----FDWRQ-KDAVTQVKNQGSCGSCWAFSVTGNIEGLY 431
                .:|.||..::......|.|:|     .|||: ..|::.:|:|.:|..|||.:..||||.|:
Human   106 ----RRAAGGVPSMGREIRSEEPEESVPFSCDWRKVASAISPIKDQKNCNCCWAMAAAGNIETLW 166

  Fly   432 AVKTGELKEFSEQELLDCDTTDSACNGGLMDNAYKAIKDIGGLEYEAEYPY--KAKKNQCHFNRT 494
            .:...:..:.|.||||||......|:||.:.:|:..:.:..||..|.:||:  |.:.::||..:.
Human   167 RISFWDFVDVSVQELLDCGRCGDGCHGGFVWDAFITVLNNSGLASEKDYPFQGKVRAHRCHPKKY 231

  Fly   495 LSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANAMQFYRGGVSHPWKALCSKKNLDHGVLV 559
            .....:..|:.| :.||..:.::|...|||::.||...:|.||.||.......|..:.:||.||:
Human   232 QKVAWIQDFIML-QNNEHRIAQYLATYGPITVTINMKPLQLYRKGVIKATPTTCDPQLVDHSVLL 295

  Fly   560 VGYG------------VS--DYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMATS 610
            ||:|            ||  ..|......||||:|||||.:|||:||:|::||.||||:::...:
Human   296 VGFGSVKSEEGIWAETVSSQSQPQPPHPTPYWILKNSWGAQWGEKGYFRLHRGSNTCGITKFPLT 360

  Fly   611 A 611
            |
Human   361 A 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsF	NP_730901.1	Inhibitor_I29	308..365	CDD:462410	22/56 (39%)
		Peptidase_C1A	395..611	CDD:239068	83/237 (35%)
CTSW	NP_001326.3	Inhibitor_I29	42..98	CDD:214853	22/55 (40%)
		Peptidase_C1A	129..358	CDD:239068	81/229 (35%)