DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and CTSS

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_004070.3	Gene:	CTSS / 1520	HGNCID:	2545	Length:	331	Species:	Homo sapiens

Alignment Length:	322	Identity:	115/322 - (35%)
Similarity:	172/322 - (53%)	Gaps:	32/322 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 HRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELN-ANEMGSAKY--GITEFADM 360
            |:...:||.::.::..:|::|....|..:|..|:.:|||.:...| .:.||...|  |:....||
Human    19 HKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDM 83

  Fly   361 TSSEYKER------TGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGSCW 419
            ||.|....      ...|||:....:..:..        ||...|||:|..||:||.|||||:||
Human    84 TSEEVMSLMSSLRVPSQWQRNITYKSNPNRI--------LPDSVDWREKGCVTEVKYQGSCGACW 140

  Fly   420 AFSVTGNIEGLYAVKTGELKEFSEQELLDCDTT---DSACNGGLMDNAYKAIKDIGGLEYEAEYP 481
            |||..|.:|....:|||:|...|.|.|:||.|.   :..||||.|..|::.|.|..|::.:|.||
Human   141 AFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYP 205

  Fly   482 YKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANAMQF--YRGGVSHPW 544
            |||...:|.::........:.:.:||.|.|..::|.:...||:|:|::|....|  ||.||.  :
Human   206 YKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVY--Y 268

  Fly   545 KALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRG-DNTCGVS 605
            :..|: :|::|||||||||..:...      ||:||||||..:||:||.|:.|. .|.||::
Human   269 EPSCT-QNVNHGVLVVGYGDLNGKE------YWLVKNSWGHNFGEEGYIRMARNKGNHCGIA 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	17/59 (29%)
		Peptidase_C1A	395..611	CDD:239068	90/217 (41%)
CTSS	NP_004070.3	PTZ00203	5..326	CDD:185513	115/322 (36%)
		Inhibitor_I29	28..87	CDD:214853	17/58 (29%)
		Peptidase_C1	115..329	CDD:278538	91/218 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710