DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and CTSO

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001325.1	Gene:	CTSO / 1519	HGNCID:	2542	Length:	321	Species:	Homo sapiens

Alignment Length:	312	Identity:	109/312 - (34%)
Similarity:	154/312 - (49%)	Gaps:	56/312 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 RQMRLRIFRQNLKTIEELNA---NEMGSAKYGITEFADMTSSEYKERTGLWQRDEAKATGGSAAV 386
            |:.....||::|.....||:   :|..:|.|||.:|:.:...|:|   .::.|.:       .:.
Human    37 REREAAAFRESLNRHRYLNSLFPSENSTAFYGINQFSYLFPEEFK---AIYLRSK-------PSK 91

  Fly   387 VPAYHGE---------LPKEFDWRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFS 442
            .|.|..|         ||..||||.|..||||:||..||.||||||.|.:|..||:|...|::.|
Human    92 FPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLS 156

  Fly   443 EQELLDCDTTDSACNGGLMDNA--------YKAIKDIGGLEYEAEYPYKAKKNQCH-FNRTLSHV 498
            .|:::||...:..||||...||        .|.:||       :|||:||:...|| |:.:.|..
Human   157 VQQVIDCSYNNYGCNGGSTLNALNWLNKMQVKLVKD-------SEYPFKAQNGLCHYFSGSHSGF 214

  Fly   499 QVAGF--VDLPKGNETAMQEWLLANGPISIGINANAMQFYRGG-VSHPWKALCSKKNLDHGVLVV 560
            .:.|:  .|. ...|..|.:.||..||:.:.::|.:.|.|.|| :.|.    ||....:|.||:.
Human   215 SIKGYSAYDF-SDQEDEMAKALLTFGPLVVIVDAVSWQDYLGGIIQHH----CSSGEANHAVLIT 274

  Fly   561 GYGVSDYPNFHKT--LPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMATS 610
            |        |.||  .|||||:||||..||..||..|..|.|.||:::..:|
Human   275 G--------FDKTGSTPYWIVRNSWGSSWGVDGYAHVKMGSNVCGIADSVSS 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	12/42 (29%)
		Peptidase_C1A	395..611	CDD:239068	90/230 (39%)
CTSO	NP_001325.1	Peptidase_C1A	109..319	CDD:239068	90/230 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810