Protein Alignment CG12163 and CTSK

DIOPT Version :9

• Sequence 1: NP_730901.1
• Gene: CG12163 / 40628
• FlyBaseID: FBgn0260462
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_000387.1
• Gene: CTSK / 1513
• HGNCID: 2536
• Length: 329
• Species: Homo sapiens
• Alignment Length: 330
• Identity: 117/330 - (35%)
• Similarity: 176/330 - (53%)
• Gaps: 41/330 - (12%)

  Fly   288 WAEKKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLK--TIEELNANEMGSA 350
            |  ||||:|..:  :|||.:                   .|..|:.:|||  :|..|.|: :|..
Human    29 W--KKTHRKQYN--NKVDEI-------------------SRRLIWEKNLKYISIHNLEAS-LGVH 69

  Fly   351 KY--GITEFADMTSSEYKER-TGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQ 412
            .|  .:....||||.|..:: ||| :...:.:.......:|.:.|..|...|:|:|..||.||||
Human    70 TYELAMNHLGDMTSEEVVQKMTGL-KVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQ 133

  Fly   413 GSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTTDSACNGGLMDNAYKAIKDIGGLEYE 477
            |.||||||||..|.:||....|||:|...|.|.|:||.:.:..|.||.|.||::.::...|::.|
Human   134 GQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSE 198

  Fly   478 AEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINAN--AMQFYRGGV 540
            ..|||..::..|.:|.|....:..|:.::|:|||.|::..:...||:|:.|:|:  :.|||..||
Human   199 DAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGV 263

  Fly   541 SHPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRG-DNTCGV 604
            .  :...|:..||:|.||.||||:      .|...:||:|||||..||.:||..:.|. :|.||:
Human   264 Y--YDESCNSDNLNHAVLAVGYGI------QKGNKHWIIKNSWGENWGNKGYILMARNKNNACGI 320

  Fly   605 SEMAT 609
            :.:|:
Human   321 ANLAS 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	14/60 (23%)
		Peptidase_C1A	395..611	CDD:239068	88/218 (40%)
CTSK	NP_000387.1	Inhibitor_I29	26..85	CDD:214853	23/79 (29%)
		Peptidase_C1	115..327	CDD:306594	88/219 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710