DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12163 and CTSH

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_004381.2	Gene:	CTSH / 1512	HGNCID:	2535	Length:	335	Species:	Homo sapiens

Alignment Length:	321	Identity:	107/321 - (33%)
Similarity:	161/321 - (50%)	Gaps:	32/321 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 DKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMG--SAKYGITEFADMTSSE 364
            :.::...:|..:...|:..||.|...||:.|..|.:   ::||:..|  :.|..:.:|:||:.:|
Human    28 NSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWR---KINAHNNGNHTFKMALNQFSDMSFAE 89

  Fly   365 YKERTGLWQRDEAKATGGSAAVVPAY---HGELPKEFDWRQK-DAVTQVKNQGSCGSCWAFSVTG 425
            .|.:. ||...:     ..:|....|   .|..|...|||:| :.|:.|||||:|||||.||.||
Human    90 IKHKY-LWSEPQ-----NCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTG 148

  Fly   426 NIEGLYAVKTGELKEFSEQELLDC--DTTDSACNGGLMDNAYKAIKDIGGLEYEAEYPYKAKKNQ 488
            .:|...|:.||::...:||:|:||  |..:..|.|||...|::.|....|:..|..|||:.|...
Human   149 ALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGY 213

  Fly   489 CHFNRTLSHVQVAGFV----DLPKGNETAMQEWLLANGPISIGINANA-MQFYRGGVSHPWKALC 548
            |.|...    :..|||    ::...:|.||.|.:....|:|....... ...||.|:........
Human   214 CKFQPG----KAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHK 274

  Fly   549 SKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMAT 609
            :...::|.||.||||..:      .:|||||||||||:||..||:.:.||.|.||::..|:
Human   275 TPDKVNHAVLAVGYGEKN------GIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACAS 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	16/58 (28%)
		Peptidase_C1A	395..611	CDD:239068	84/223 (38%)
CTSH	NP_004381.2	Inhibitor_I29	35..90	CDD:285458	16/57 (28%)
CTSH	NP_004381.2	Peptidase_C1	117..332	CDD:278538	84/223 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810