DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and CTSB

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001371643.1	Gene:	CTSB / 1508	HGNCID:	2527	Length:	339	Species:	Homo sapiens

Alignment Length:	264	Identity:	68/264 - (25%)
Similarity:	107/264 - (40%)	Gaps:	57/264 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 ELPKEFD----WRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGE--LKEFSEQELLDC-- 449
            :||..||    |.|...:.::::||||||||||.....|.....:.|..  ..|.|.::||.|
Human    79 KLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCG 143

  Fly   450 DTTDSACNGGLMDNAY-----KAIKDIGGLEYEAEY---PYKAKKNQCHFNRTLSHVQVAGFVDL 506
            ......||||....|:     |.:.. ||| ||:..   ||.....:.|.|.  |.....|..|.
Human   144 SMCGDGCNGGYPAEAWNFWTRKGLVS-GGL-YESHVGCRPYSIPPCEHHVNG--SRPPCTGEGDT 204

  Fly   507 PK---------------------------GNETAMQEWLLANGPISIGINA-NAMQFYRGGVSHP 543
            ||                           .:|..:...:..|||:....:. :....|:.||
Human   205 PKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGV--- 266

  Fly   544 WKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMA 608
            ::.:..:....|.:.::|:||.:      ..|||:|.|||...||:.|::::.||.:.||:....
Human   267 YQHVTGEMMGGHAIRILGWGVEN------GTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEV 325

  Fly   609 TSAV 612
            .:.:
Human   326 VAGI 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458
		Peptidase_C1A	395..611	CDD:239068	67/259 (26%)
CTSB	NP_001371643.1	Propeptide_C1	26..65	CDD:400445
CTSB	NP_001371643.1	Peptidase_C1A_CathepsinB	81..328	CDD:239111	67/259 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810