DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12163 and Ctsw

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_034115.2	Gene:	Ctsw / 13041	MGIID:	1338045	Length:	371	Species:	Mus musculus

Alignment Length:	324	Identity:	116/324 - (35%)
Similarity:	181/324 - (55%)	Gaps:	17/324 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 KVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGSAKYGITEFADMTSSEYKE 367
            ::..:|..||:||.|.|.:.||...||.||..||...:.|...::|:|::|.|.|:|:|..|:.:
Mouse    35 ELKEVFKLFQIRFNRSYWNPAEYTRRLSIFAHNLAQAQRLQQEDLGTAEFGETPFSDLTEEEFGQ 99

  Fly   368 RTGLWQRDEAKATGGSAAVVPAYHGE-LPKEFDWRQ-KDAVTQVKNQGSCGSCWAFSVTGNIEGL 430
            ..| .:|...:....:..|.....|| :|:..|||: |:.::.|||||||..|||.:...||:.|
Mouse   100 LYG-QERSPERTPNMTKKVESNTWGESVPRTCDWRKAKNIISSVKNQGSCKCCWAMAAADNIQAL 163

  Fly   431 YAVKTGELKEFSEQELLDCDTTDSACNGGLMDNAYKAIKDIGGLEYEAEYPYKA--KKNQCHFNR 493
            :.:|..:..:.|.||||||:...:.||||.:.:||..:.:..||..|.:||::.  |.::|...:
Mouse   164 WRIKHQQFVDVSVQELLDCERCGNGCNGGFVWDAYLTVLNNSGLASEKDYPFQGDRKPHRCLAKK 228

  Fly   494 TLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANAMQFYRGGVSHPWKALCSKKNLDHGVL 558
            ......:..|..| ..||.|:..:|..:|||::.||...:|.|:.||.....:.|..:.:||.||
Mouse   229 YKKVAWIQDFTML-SNNEQAIAHYLAVHGPITVTINMKLLQHYQKGVIKATPSSCDPRQVDHSVL 292

  Fly   559 VVGYG-----------VSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMATSA 611
            :||:|           :|.......:.||||:|||||..|||:||:|:|||:|||||::...:|
Mouse   293 LVGFGKEKEGMQTGTVLSHSRKRRHSSPYWILKNSWGAHWGEKGYFRLYRGNNTCGVTKYPFTA 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	23/56 (41%)
		Peptidase_C1A	395..611	CDD:239068	86/229 (38%)
Ctsw	NP_034115.2	Inhibitor_I29	40..96	CDD:214853	23/55 (42%)
Ctsw	NP_034115.2	Peptidase_C1	126..356	CDD:278538	86/230 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11410
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920