DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12163 and Ctss

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001254624.2	Gene:	Ctss / 13040	MGIID:	107341	Length:	341	Species:	Mus musculus

Alignment Length:	332	Identity:	125/332 - (37%)
Similarity:	173/332 - (52%)	Gaps:	52/332 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 WAEKKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNAN-EMGSAK 351
            |  ||||:|                     .|....|.::|..|:.:|||.|...|.. .||...
Mouse    40 W--KKTHEK---------------------EYKDKNEEEVRRLIWEKNLKFIMIHNLEYSMGMHT 81

  Fly   352 Y--GITEFADMTSSEYKERTGLWQ--RDEAKATGGSAAVVPAYHGE-LPKEFDWRQKDAVTQVKN 411
            |  |:.:..|||:.|...|.|..:  |...|     .....:|... ||...|||:|..||:||.
Mouse    82 YQVGMNDMGDMTNEEILCRMGALRIPRQSPK-----TVTFRSYSNRTLPDTVDWREKGCVTEVKY 141

  Fly   412 QGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTTD----SACNGGLMDNAYKAIKDIG 472
            |||||:|||||..|.:||...:|||:|...|.|.|:||...:    ..|.||.|..|::.|.|.|
Mouse   142 QGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSNEEKYGNKGCGGGYMTEAFQYIIDNG 206

  Fly   473 GLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINA--NAMQF 535
            |:|.:|.|||||...:||:|........:.::.||.|:|.|::|.:...||:|:||:|  ::..|
Mouse   207 GIEADASYPYKATDEKCHYNSKNRAATCSRYIQLPFGDEDALKEAVATKGPVSVGIDASHSSFFF 271

  Fly   536 YRGGV-SHPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGD 599
            |:.|| ..|   .|: .|::|||||||||..|..:      ||:||||||..:|:|||.|:.|.:
Mouse   272 YKSGVYDDP---SCT-GNVNHGVLVVGYGTLDGKD------YWLVKNSWGLNFGDQGYIRMARNN 326

  Fly   600 -NTCGVS 605
             |.||::
Mouse   327 KNHCGIA 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	16/59 (27%)
		Peptidase_C1A	395..611	CDD:239068	96/219 (44%)
Ctss	NP_001254624.2	Inhibitor_I29	37..96	CDD:214853	22/78 (28%)
Ctss	NP_001254624.2	Peptidase_C1	124..339	CDD:278538	97/220 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710