DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Ctsl

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_034114.1	Gene:	Ctsl / 13039	MGIID:	88564	Length:	334	Species:	Mus musculus

Alignment Length:	342	Identity:	130/342 - (38%)
Similarity:	190/342 - (55%)	Gaps:	43/342 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 TRSVEWAE-KKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANE 346
            |.|.||.: |.||                      ||...|.|.:.|..|:.:|::.| :|:..|
Mouse    24 TFSAEWHQWKSTH----------------------RRLYGTNEEEWRRAIWEKNMRMI-QLHNGE 65

  Fly   347 MGSAKYG----ITEFADMTSSEYKERTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVT 407
            ..:.::|    :..|.|||:.|:::....::..:.|.  |.....|... ::||..|||:|..||
Mouse    66 YSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHKK--GRLFQEPLML-KIPKSVDWREKGCVT 127

  Fly   408 QVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTT--DSACNGGLMDNAYKAIKD 470
            .|||||.||||||||.:|.:||...:|||:|...|||.|:||...  :..|||||||.|::.||:
Mouse   128 PVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKE 192

  Fly   471 IGGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINAN--AM 533
            .|||:.|..|||:||...|.:....:.....||||:|: .|.|:.:.:...||||:.::|:  ::
Mouse   193 NGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSL 256

  Fly   534 QFYRGGVSHPWKALCSKKNLDHGVLVVGYGVSDY-PNFHKTLPYWIVKNSWGPRWGEQGYYRVYR 597
            |||..|:.  ::..||.||||||||:||||.... .|.:|   ||:||||||..||.:||.::.:
Mouse   257 QFYSSGIY--YEPNCSSKNLDHGVLLVGYGYEGTDSNKNK---YWLVKNSWGSEWGMEGYIKIAK 316

  Fly   598 G-DNTCGVSEMATSAVL 613
            . ||.||::..|:..|:
Mouse   317 DRDNHCGLATAASYPVV 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	15/60 (25%)
		Peptidase_C1A	395..611	CDD:239068	103/221 (47%)
Ctsl	NP_034114.1	Inhibitor_I29	29..87	CDD:214853	19/80 (24%)
Ctsl	NP_034114.1	Peptidase_C1	114..331	CDD:365882	103/222 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710