Protein Alignment CtsF and Ctsc

DIOPT Version :10

• Sequence 1: NP_730901.1
• Gene: CtsF / 40628
• FlyBaseID: FBgn0260462
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_034112.3
• Gene: Ctsc / 13032
• MGIID: 109553
• Length: 462
• Species: Mus musculus
• Alignment Length: 367
• Identity: 99/367 - (26%)
• Similarity: 163/367 - (44%)
• Gaps: 75/367 - (20%)

  Fly   308 FYKFQVR-------------------FGRRYVSTAERQMRLRIFRQNLKTI----------EELN 343
            |:|::||                   .||.:.....:::...|.:.|:...          |.|.
Mouse   104 FFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLY 168

  Fly   344 ANEMGSAKYGITEFADMTSSEYKERTGLWQRDEAKATGGSAAV---VPAYHGE--------LPKE 397
            .:.....|...|.....|::.|||...:..||..:.:|.|..:   .||...:        ||:.
Mouse   169 THNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPES 233

  Fly   398 FDWRQKDA---VTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKE--FSEQELLDCDTTDSACN 457
            :|||....   |:.|:||.|||||::|:..|.:|....:.|...:.  .|.||::.|......|:
Mouse   234 WDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCD 298

  Fly   458 GG---LMDNAYKAIKDIGGLEYEAEYPYKAKKNQCHFNR------TLSHVQVAGFVDLPKG-NET 512
            ||   |:  |.|..:|.|.:| |:.:||.||.:.|....      :..:..|.||..   | ||.
Mouse   299 GGFPYLI--AGKYAQDFGVVE-ESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYG---GCNEA 357

  Fly   513 AMQEWLLANGPISIG--INANAMQFYRG-----GVSHPWKALCSKKNLDHGVLVVGYGVSDYPNF 570
            .|:..|:.:||:::.  ::.:.:.::.|     |:|.|:...   :..:|.||:||||......
Mouse   358 LMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPF---ELTNHAVLLVGYGRDPVTG- 418

  Fly   571 HKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSEMATSAV 612
               :.|||:|||||..|||.||:|:.||.:.|.:..:|.:|:
Mouse   419 ---IEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAI 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsF	NP_730901.1	Inhibitor_I29	308..365	CDD:462410	13/85 (15%)
		Peptidase_C1A	395..611	CDD:239068	75/237 (32%)
Ctsc	NP_034112.3	CathepsinC_exc	25..138	CDD:462598	6/33 (18%)
		Pox_I6	168..>204	CDD:333259	8/35 (23%)
		Peptidase_C1A_CathepsinC	230..459	CDD:239112	77/241 (32%)