DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Ctsb

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_031824.1	Gene:	Ctsb / 13030	MGIID:	88561	Length:	339	Species:	Mus musculus

Alignment Length:	266	Identity:	70/266 - (26%)
Similarity:	108/266 - (40%)	Gaps:	61/266 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 ELPKEFD----WRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKT-GELK-EFSEQELLDC-- 449
            :||:.||    |.....:.|:::||||||||||.....|.....:.| |.:. |.|.::||.|
Mouse    79 DLPETFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAEDLLTCCG 143

  Fly   450 DTTDSACNGGLMDNAY-----KAIKDIGGLEYEAE---YPYKAKKNQCHFNRTLSHVQVAGFVDL 506
            ......||||....|:     |.:  :.|..|.:.   .||.....:.|.|.  |.....|..|.
Mouse   144 IQCGDGCNGGYPSGAWSFWTKKGL--VSGGVYNSHVGCLPYTIPPCEHHVNG--SRPPCTGEGDT 204

  Fly   507 PKGNETA----------------------------MQEWLLANGPISIGINANAMQF--YRGGVS 541
            |:.|::.                            |.| :..|||:. |.......|  |:.||
Mouse   205 PRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAE-IYKNGPVE-GAFTVFSDFLTYKSGV- 266

  Fly   542 HPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDNTCGVSE 606
              :|.........|.:.::|:||.:      .:|||:..|||...||:.|::::.||:|.||:..
Mouse   267 --YKHEAGDMMGGHAIRILGWGVEN------GVPYWLAANSWNLDWGDNGFFKILRGENHCGIES 323

  Fly   607 MATSAV 612
            ...:.:
Mouse   324 EIVAGI 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458
		Peptidase_C1A	395..611	CDD:239068	69/261 (26%)
Ctsb	NP_031824.1	Propeptide_C1	26..65	CDD:285358
Ctsb	NP_031824.1	Peptidase_C1A_CathepsinB	81..328	CDD:239111	69/261 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810