DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and AgaP_AGAP004531

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	XP_313831.5	Gene:	AgaP_AGAP004531 / 1274676	VectorBaseID:	AGAP004531	Length:	375	Species:	Anopheles gambiae

Alignment Length:	334	Identity:	78/334 - (23%)
Similarity:	135/334 - (40%)	Gaps:	60/334 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 FYKFQVRFGRRYVSTAERQMRLRIFRQ---NLKT-----IEELNANEMGSAKYGITEFADMTSSE 364
            :|:....:|.|:..::  ......||.   |:.|     :|.:| |...:.|.|:.   ...:.:
Mosquito    45 YYRDSASYGSRFADSS--SFAPEFFRTGYGNVLTSQAAFVEAIN-NRSTTWKAGVN---PQRNDQ 103

  Fly   365 YKERTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQK----DAVTQVKNQGSCGSCWAFSVTG 425
            |  |||:...:..|.......|:......||..||.|||    .::..|:|||.|.|.:|.:...
Mosquito   104 Y--RTGVLSDESMKFQLPLGFVLKKDEQPLPMSFDARQKWSYCPSMNMVRNQGCCDSSYAVAAVS 166

  Fly   426 NIEGLYAVKT-GELK-EFSEQELLD-CDTTDSACNGGL--------MDNAYKAIKDIGGLEYEAE 479
            .:...:.|.: |:.: .|...::|. |......|:||:        ::|...:....|..|....
Mosquito   167 TMTDRWCVHSEGKAQFNFGAYDVLSCCHRCGFGCDGGVPSAVWHYWVENGITSGGAFGSHEGCQS 231

  Fly   480 YPYKAKKN--------------QCHFNRTLSHVQVAGFV--DLPKGNETAMQEWLLANGP--ISI 526
            ||:...|.              |..:|.|....:..|.|  .:||..|..|.| :...||  .:.
Mosquito   232 YPFDVCKKSGDSNDTPRCLRFCQPGYNVTYPEDKHYGRVAYTVPKDEERIMYE-VFNFGPAQATF 295

  Fly   527 GINANAMQFYRGGVSHPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQG 591
            .:..:.:|:..|...|.:.....    .|.|.|:|:||.:      .:.||:..||||.:||:.|
Mosquito   296 TMYTDFVQYKSGVYRHTFGVRVG----THSVKVMGWGVEN------DVKYWLCANSWGAQWGDGG 350

  Fly   592 YYRVYRGDN 600
            ::::.||::
Mosquito   351 FFKIVRGED 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	12/64 (19%)
		Peptidase_C1A	395..611	CDD:239068	59/239 (25%)
AgaP_AGAP004531	XP_313831.5	Propeptide_C1	81..>97	CDD:285358	5/16 (31%)
AgaP_AGAP004531	XP_313831.5	Peptidase_C1A_CathepsinB	132..370	CDD:239111	59/239 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810