DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and AgaP_AGAP007684

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	XP_001687862.1	Gene:	AgaP_AGAP007684 / 1269545	VectorBaseID:	AGAP007684	Length:	463	Species:	Anopheles gambiae

Alignment Length:	296	Identity:	84/296 - (28%)
Similarity:	124/296 - (41%)	Gaps:	57/296 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 TEFADMTSSEYKE----RTGLWQ-RDEAKA-----TGGSAAVVPAYHGELPKEFD----WRQKDA 405
            |.:::....:|.|    |.|.:| |...||     ..|         |.||..||    |  ...
Mosquito   147 TNYSEWWGHKYDEGKVLRLGTFQPRFRVKAMKRLSNKG---------GHLPTRFDASEHW--TGL 200

  Fly   406 VTQVKNQGSCGSCWAFSVTGNIEGLYAV--KTGELKEFSEQELLDCDTTDSACNGGLMDNAYKAI 468
            |.:.::||.|||.||||........:|:  |..|:.:.:.|::|.|......|:||.:|.|::.:
Mosquito   201 VAEARDQGWCGSSWAFSTATMASDRFAILSKGREMVQLAPQQMLACVRRQQGCSGGHLDTAWQYL 265

  Fly   469 KDIGGLEYEAEYPYKAKKNQCHF-----------------NRTLSHVQVAGFVDLPKGNETAMQE 516
            :..|.:..|. |||.|.:|.|..                 ||||.:.....|   ...|||.:..
Mosquito   266 RRTGVVNEEC-YPYIAAQNVCKISNDDTLITANCELPVKVNRTLMYKMGPAF---SLNNETDIMA 326

  Fly   517 WLLANGPISIGINANAMQF-YRGGV-SHPWKAL-CSKKNLDHGVLVVGYGVSDYPNFHKTLPYWI 578
            .:...|.:...:......| ||.|: .|...|. ..:::..|.|.::|:|.....  :..:.|||
Mosquito   327 EIKDRGTVQAIMRVYRDFFSYRSGIYRHSAAATPAEERSAYHSVRLIGWGEERVG--YDVVKYWI 389

  Fly   579 VKNSWGPRWGEQGYYRVYRGDNTCGVSEMATSAVLA 614
            ..||||..|||.|.:|:.||.|.|.:.    |.|||
Mosquito   390 AINSWGQWWGENGRFRILRGSNECDIE----SYVLA 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	1/9 (11%)
		Peptidase_C1A	395..611	CDD:239068	68/241 (28%)
AgaP_AGAP007684	XP_001687862.1	Somatomedin_B	37..78	CDD:279385
		VWC	89..>136	CDD:302663
		Peptidase_C1A_CathepsinB	188..421	CDD:239111	70/244 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910