DRSC/TRiP Functional Genomics Resources

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Protein Alignment rtp and ALS2

DIOPT Version :9

Sequence 1:NP_649520.1 Gene:rtp / 40627 FlyBaseID:FBgn0087005 Length:198 Species:Drosophila melanogaster
Sequence 2:NP_065970.2 Gene:ALS2 / 57679 HGNCID:443 Length:1657 Species:Homo sapiens


Alignment Length:213 Identity:56/213 - (26%)
Similarity:81/213 - (38%) Gaps:55/213 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 GHHQQGQ--GQSQYS------------------AGAVKVGGWRYEDASRYIGEWNQRGQKHGIGH 79
            ||.::|:  ||..||                  .|.::.|.......|.:||:| ...:|.|.| 
Human  1102 GHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQW-VMDKKAGYG- 1164

  Fly    80 LQFAD---GTRYDGQFQEGLSQGVGCLWFADGAKYEGEFHQGWFHGNGIFWRADGMKYEGEFRGG 141
             .|.|   |.:|.|.:|:.:.||.|.:....|..|||.||.....|||:....|...|||||...
Human  1165 -VFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDD 1228

  Fly   142 KIW---GLGLLTFQ--DFTHGFPRNE---------GFFQDCRFMRRRRCPEVVQRAQKCALMARS 192
              |   |.|.||..  |:..|:...|         .:|:...:...:..|:|.::....|:.|..
Human  1229 --WTLSGKGTLTMPNGDYIEGYFSGEWGSGIKITGTYFKPSLYESDKDRPKVFRKLGNLAVPADE 1291

  Fly   193 Q-------------CEHP 197
            :             ||.|
Human  1292 KWKAVFDECWRQLGCEGP 1309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rtpNP_649520.1 COG4642 54..>151 CDD:332236 36/102 (35%)
ALS2NP_065970.2 RCC1 1. /evidence=ECO:0000305 59..108
RCC1_2 93..122 CDD:290274
RCC1 2. /evidence=ECO:0000305 109..167
RCC1 109..165 CDD:278826
RCC1 3. /evidence=ECO:0000305 169..218
RCC1 170..216 CDD:278826
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 432..480
RCC1 4. /evidence=ECO:0000305 525..576
RCC1 527..574 CDD:278826
RCC1 5. /evidence=ECO:0000305 578..627
RCC1 579..625 CDD:278826
RhoGEF 695..879 CDD:295373
PH_alsin 905..1010 CDD:241423
PH 926..1004 CDD:278594
COG4642 1049..1188 CDD:226989 24/88 (27%)
MORN 1 1049..1071
MORN 1049..1069 CDD:280628
MORN 2 1072..1094
MORN 3 1100..1122 7/19 (37%)
MORN 1100..1120 CDD:280628 7/17 (41%)
MORN 4 1123..1145 2/21 (10%)
MORN 5 1151..1173 8/24 (33%)
MORN 6 1175..1197 7/21 (33%)
MORN 7 1198..1220 9/21 (43%)
MORN 8 1221..1244 10/24 (42%)
VPS9 1554..1653 CDD:280383
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG4642
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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