DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rtp and Als2cl

DIOPT Version :9

Sequence 1:	NP_649520.1	Gene:	rtp / 40627	FlyBaseID:	FBgn0087005	Length:	198	Species:	Drosophila melanogaster
Sequence 2:	XP_006244073.1	Gene:	Als2cl / 316017	RGDID:	1305208	Length:	952	Species:	Rattus norvegicus

Alignment Length:	291	Identity:	58/291 - (19%)
Similarity:	80/291 - (27%)	Gaps:	158/291 - (54%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 YIGEWNQRGQKHGIGHLQFADGTRYDGQFQEGLSQGVG----------------CLW-------- 104
            |.|||: |.:.||.|.|::.||..:.|.|.:||..|.|                |.|
  Rat   358 YDGEWS-RAKPHGKGTLKWPDGRNHVGDFYQGLEHGFGICLVPQASEDKFDCYKCHWREGRMCEY 421

  Fly   105 ----FADGAKYEGEFHQGWFHGNGI---------------------------------------F 126
                :.....|:|.|..|..||.|:                                       .
  Rat   422 GICEYGTDEVYKGYFQAGVRHGFGVLDSAPQAPQPFRYTGHWERGQRSGYGIEEDRDRGERYIGM 486

  Fly   127 WRAD------------GMKYEGEFRGGKIWGLGLLTFQD---------------------FTHGF 158
            |:||            |:.|:|.|:|.|:.|.|:|..:|                     |.:||
  Rat   487 WQADQRHGPGIVVTQAGVCYQGTFQGDKMAGPGILLCEDDSLYEGTFTRELTLLGKGKVTFPNGF 551

  Fly   159 -------------------------PRN--------------------EGFFQDCRFMRRRRCPE 178
                                     |.|                    :|.:...|...|..||.
  Rat   552 TLEGSFCSGTDKGLYTQGVLDTTALPPNPSSTRKRQLGLGAFPVESRWQGVYSPFRDFLRLGCPG 616

  Fly   179 VVQRA------QKCALMARSQ----CE--HP 197
            .:|.|      |....:.:||    ||  ||
  Rat   617 ELQEALLGFHVQSSRELRKSQEYLCCERSHP 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rtp	NP_649520.1	COG4642	54..>151	CDD:332236	38/165 (23%)
Als2cl	XP_006244073.1	PH-like	223..321	CDD:418428
		PLN03185	357..>550	CDD:215619	40/192 (21%)
		VPS9	835..937	CDD:388595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900