DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mms19 and MET18

DIOPT Version :9

Sequence 1:	NP_649519.1	Gene:	Mms19 / 40626	FlyBaseID:	FBgn0037301	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_012138.1	Gene:	MET18 / 854678	SGDID:	S000001390	Length:	1032	Species:	Saccharomyces cerevisiae

Alignment Length:	1098	Identity:	240/1098 - (21%)
Similarity:	431/1098 - (39%)	Gaps:	250/1098 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DQKLVNSATQIAKDLTAKAYDISALAEAL-GFALSSPDMEERVAGTNLLSAVLIALPQDLLQERQ 79
            |.|...:|:.:...:..::..:..:..|| .:.||..::|.:.|.| .|:.:|...|:|.|.:.:
Yeast    21 DSKANETASTVTDSIVHRSIKLLEVVVALKDYFLSENEVERKKALT-CLTTILAKTPKDHLSKNE 84

  Fly    80 LEFLSTFYMDRLRDHHNVMPAIIDGIDALVHMKALPRAQIPQILQSFFEHTTCQSQTRSDRTKLF 144
            ...:..||..:| |...:...:::|..||..||.:...:|.|:|:...::........|.|...|
Yeast    85 CSVIFQFYQSKL-DDQALAKEVLEGFAALAPMKYVSINEIAQLLRLLLDNYQQGQHLASTRLWPF 148

  Fly   145 HIFQYLTENF------QDELQAMAGDFVYGLINSIDGERDPRNLDIIFSFMPEFLSTYP-LLHLA 202
            .|.:.:.:.|      .::::.:...|:...::..:||:|||||.:.|:......|:.. :.:..
Yeast   149 KILRKIFDRFFVNGSSTEQVKRINDLFIETFLHVANGEKDPRNLLLSFALNKSITSSLQNVENFK 213

  Fly   203 EEMFEIFACYFPIDFNPSKQDPAAITRDELSKKLTNCLVANNEFAEGTVVLAIEKLESELLVAKL 267
            |::|::..|||||.|.|.|.||..|:..:|...|.:.:.|...|||......::||.:...|.|.
Yeast   214 EDLFDVLFCYFPITFKPPKHDPYKISNQDLKTALRSAITATPLFAEDAYSNLLDKLTASSPVVKN 278

  Fly   268 DSIELLHQAAVKFPPSVLEPHFDQIWQALKTETFPGNDNEEILKASLKALSALLERAAHIPDISH 332
            |::..|.:...||..|.:..::..:|.|||.|....::..|         :.||.      ..:.
Yeast   279 DTLLTLLECVRKFGGSSILENWTLLWNALKFEIMQNSEGNE---------NTLLN------PYNK 328

  Fly   333 SYQSSILGVILPHLSDVNQRLFHPATGIALVCVSGDAPYAADKILNSFLLKLQAADASSEQRIKI 397
            ..||          .||.|...:.|      |:         ||:|...|:|...|       |:
Yeast   329 DQQS----------DDVGQYTNYDA------CL---------KIINLMALQLYNFD-------KV 361

  Fly   398 YYIVSQVYKLSALRGSLQKLDTTIRESVQ-------------DDVIAS---LRLIEQEEFDAKKE 446
            .:.....:.|..|:.:. |.:..::::.|             :.||:|   |.||...
Yeast   362 SFEKFFTHVLDELKPNF-KYEKDLKQTCQILSAIGSGNVEIFNKVISSTFPLFLINTS------- 418

  Fly   447 DLELQKAALSVLNES-------------------APLLNEK------------QRALIYKALVQL 480
              |:.|..|.::|.|                   .|:.|.|            ..||...:..::
Yeast   419 --EVAKLKLLIMNFSFFVDSYIDLFGRTSKESLGTPVPNNKMAEYKDEIIMILSMALTRSSKAEV 481

  Fly   481 VSHPSIDIDFTTLTVSLGALQPVEV---------------QSNFIDVCVRNF----EIFSTFVKR 526
            .......|.||.:....|.|.|.||               ..|....|:...    ||:...|..
Yeast   482 TIRTLSVIQFTKMIKMKGFLTPEEVSLIIQYFTEEILTDNNKNIYYACLEGLKTISEIYEDLVFE 546

  Fly   527 KIYTNLLPLMPQIAFTQRI---------LDLVMTQTFNDTTA------EPVRLLALEALNKLLLL 576
            .....||.|:|. .|.::|         ::.::....:.||:      |.:..||.: ||::..:
Yeast   547 ISLKKLLDLLPD-CFEEKIRVNDEENIHIETILKIILDFTTSRHILVKESITFLATK-LNRVAKI 609

  Fly   577 ADQR---FIV---------DVQQESNLLHKLIELGQKTEGLSMQSLEQIAGALSRITQQLPLSEQ 629
            :..|   |::         :..|..|:|:       :.:.|::::  .|...|..|     ::::
Yeast   610 SKSREYCFLLISTIYSLFNNNNQNENVLN-------EEDALALKN--AIEPKLFEI-----ITQE 660

  Fly   630 SAIVSE-----------YLPGLNLSQSA---------DLYITKG-----------------LLGY 657
            |||||:           :...|.:.|:|         :|:|::|                 :|..
Yeast   661 SAIVSDNYNLTLLSNVLFFTNLKIPQAAHQEELDRYNELFISEGKIRILDTPNVLAISYAKILSA 725

  Fly   658 LHKDITLDDHFERLLTDLTQLSLN----SDNEQLRVIAHHLLCSMVNKMESNPANLRKVKKITEQ 718
            |:|:......|..|...:..|..:    ::.|:|..:  .||..:.||.            ::|:
Yeast   726 LNKNCQFPQKFTVLFGTVQLLKKHAPRMTETEKLGYL--ELLLVLSNKF------------VSEK 776

  Fly   719 LKVAI---KKGDVRAVEILAWVGKGLVVAGFDEAADVVGDLSDLLKHPSLSTAAALGFDIIAAEY 780
            ..:.:   |...|..:|::.|:.|||::....|::::.....|||.:..:.:..:..|::...:.
Yeast   777 DVIGLFDWKDLSVINLEVMVWLTKGLIMQNSLESSEIAKKFIDLLSNEEIGSLVSKLFEVFVMDI 841

  Fly   781 PELDL-------PVVKFLYKQKLFHTIMGKMGSKLAN------YCVHHLKAFVYVLKATPQAVIK 832
            ..|..       ..||.|||||.|..|...:.|...|      .| ::|.|...|||.||...:.
Yeast   842 SSLKKFKGISWNNNVKILYKQKFFGDIFQTLVSNYKNTVDMTIKC-NYLTALSLVLKHTPSQSVG 905

  Fly   833 LNIEQLGPLLFKSLEEHNEAQSLCIALGICEKFVAQQDTYFQGHLAHLIPSCLELSKYKAQHTMQ 897
            ..|..|.|||.::| :..:.:....||...:....:..|....|::.::|..|.||.....:::.
Yeast   906 PFINDLFPLLLQAL-DMPDPEVRVSALETLKDTTDKHHTLITEHVSTIVPLLLSLSLPHKYNSVS 969

  Fly   898 VRIAALQLLYDVTK-YPTFVLLPHKVDVTLALAAALDDPKRLVRNTAVKARNAWYLVG 954
            ||:.|||||..:|. .|....|.::.||..||...|.|.||::|...|..|..:|.:|
Yeast   970 VRLIALQLLEMITTVVPLNYCLSYQDDVLSALIPVLSDKKRIIRKQCVDTRQVYYELG 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mms19	NP_649519.1	MMS19_N	44..301	CDD:291186	71/264 (27%)
Mms19	NP_649519.1	MMS19_C	<658..887	CDD:289245	56/248 (23%)
MET18	NP_012138.1	MMS19_N	49..313	CDD:405225	71/265 (27%)
MET18	NP_012138.1	MMS19_C	567..953	CDD:403605	82/416 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341352
Domainoid	1	1.000	102	1.000	Domainoid score	I1525
eggNOG	1	0.900	-	-		E1_KOG1967
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	192	1.000	Inparanoid score	I900
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55367
OrthoFinder	1	1.000	-	-		FOG0003902
OrthoInspector	1	1.000	-	-		oto99604
orthoMCL	1	0.900	-	-		OOG6_102900
Panther	1	1.100	-	-	LDO	PTHR12891
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R725
SonicParanoid	1	1.000	-	-		X2685
TreeFam	1	0.960	-	-
	13	12.880