Protein Alignment Mms19 and MET18

DIOPT Version :10

• Sequence 1: NP_649519.1
• Gene: Mms19 / 40626
• FlyBaseID: FBgn0037301
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: NP_012138.1
• Gene: MET18 / 854678
• SGDID: S000001390
• Length: 1032
• Species: Saccharomyces cerevisiae
• Alignment Length: 1098
• Identity: 240/1098 - (21%)
• Similarity: 431/1098 - (39%)
• Gaps: 250/1098 - (22%)

  Fly    16 DQKLVNSATQIAKDLTAKAYDISALAEAL-GFALSSPDMEERVAGTNLLSAVLIALPQDLLQERQ 79
            |.|...:|:.:...:..::..:..:..|| .:.||..::|.:.|.| .|:.:|...|:|.|.:.:
Yeast    21 DSKANETASTVTDSIVHRSIKLLEVVVALKDYFLSENEVERKKALT-CLTTILAKTPKDHLSKNE 84

  Fly    80 LEFLSTFYMDRLRDHHNVMPAIIDGIDALVHMKALPRAQIPQILQSFFEHTTCQSQTRSDRTKLF 144
            ...:..||..:| |...:...:::|..||..||.:...:|.|:|:...::........|.|...|
Yeast    85 CSVIFQFYQSKL-DDQALAKEVLEGFAALAPMKYVSINEIAQLLRLLLDNYQQGQHLASTRLWPF 148

  Fly   145 HIFQYLTENF------QDELQAMAGDFVYGLINSIDGERDPRNLDIIFSFMPEFLSTYP-LLHLA 202
            .|.:.:.:.|      .::::.:...|:...::..:||:|||||.:.|:......|:.. :.:..
Yeast   149 KILRKIFDRFFVNGSSTEQVKRINDLFIETFLHVANGEKDPRNLLLSFALNKSITSSLQNVENFK 213

  Fly   203 EEMFEIFACYFPIDFNPSKQDPAAITRDELSKKLTNCLVANNEFAEGTVVLAIEKLESELLVAKL 267
            |::|::..|||||.|.|.|.||..|:..:|...|.:.:.|...|||......::||.:...|.|.
Yeast   214 EDLFDVLFCYFPITFKPPKHDPYKISNQDLKTALRSAITATPLFAEDAYSNLLDKLTASSPVVKN 278

  Fly   268 DSIELLHQAAVKFPPSVLEPHFDQIWQALKTETFPGNDNEEILKASLKALSALLERAAHIPDISH 332
            |::..|.:...||..|.:..::..:|.|||.|....::..|         :.||.      ..:.
Yeast   279 DTLLTLLECVRKFGGSSILENWTLLWNALKFEIMQNSEGNE---------NTLLN------PYNK 328

  Fly   333 SYQSSILGVILPHLSDVNQRLFHPATGIALVCVSGDAPYAADKILNSFLLKLQAADASSEQRIKI 397
            ..||          .||.|...:.|      |:         ||:|...|:|...|       |:
Yeast   329 DQQS----------DDVGQYTNYDA------CL---------KIINLMALQLYNFD-------KV 361

  Fly   398 YYIVSQVYKLSALRGSLQKLDTTIRESVQ-------------DDVIAS---LRLIEQEEFDAKKE 446
            .:.....:.|..|:.:. |.:..::::.|             :.||:|   |.||...
Yeast   362 SFEKFFTHVLDELKPNF-KYEKDLKQTCQILSAIGSGNVEIFNKVISSTFPLFLINTS------- 418

  Fly   447 DLELQKAALSVLNES-------------------APLLNEK------------QRALIYKALVQL 480
              |:.|..|.::|.|                   .|:.|.|            ..||...:..::
Yeast   419 --EVAKLKLLIMNFSFFVDSYIDLFGRTSKESLGTPVPNNKMAEYKDEIIMILSMALTRSSKAEV 481

  Fly   481 VSHPSIDIDFTTLTVSLGALQPVEV---------------QSNFIDVCVRNF----EIFSTFVKR 526
            .......|.||.:....|.|.|.||               ..|....|:...    ||:...|..
Yeast   482 TIRTLSVIQFTKMIKMKGFLTPEEVSLIIQYFTEEILTDNNKNIYYACLEGLKTISEIYEDLVFE 546

  Fly   527 KIYTNLLPLMPQIAFTQRI---------LDLVMTQTFNDTTA------EPVRLLALEALNKLLLL 576
            .....||.|:|. .|.::|         ::.::....:.||:      |.:..||.: ||::..:
Yeast   547 ISLKKLLDLLPD-CFEEKIRVNDEENIHIETILKIILDFTTSRHILVKESITFLATK-LNRVAKI 609

  Fly   577 ADQR---FIV---------DVQQESNLLHKLIELGQKTEGLSMQSLEQIAGALSRITQQLPLSEQ 629
            :..|   |::         :..|..|:|:       :.:.|::::  .|...|..|     ::::
Yeast   610 SKSREYCFLLISTIYSLFNNNNQNENVLN-------EEDALALKN--AIEPKLFEI-----ITQE 660

  Fly   630 SAIVSE-----------YLPGLNLSQSA---------DLYITKG-----------------LLGY 657
            |||||:           :...|.:.|:|         :|:|::|                 :|..
Yeast   661 SAIVSDNYNLTLLSNVLFFTNLKIPQAAHQEELDRYNELFISEGKIRILDTPNVLAISYAKILSA 725

  Fly   658 LHKDITLDDHFERLLTDLTQLSLN----SDNEQLRVIAHHLLCSMVNKMESNPANLRKVKKITEQ 718
            |:|:......|..|...:..|..:    ::.|:|..:  .||..:.||.            ::|:
Yeast   726 LNKNCQFPQKFTVLFGTVQLLKKHAPRMTETEKLGYL--ELLLVLSNKF------------VSEK 776

  Fly   719 LKVAI---KKGDVRAVEILAWVGKGLVVAGFDEAADVVGDLSDLLKHPSLSTAAALGFDIIAAEY 780
            ..:.:   |...|..:|::.|:.|||::....|::::.....|||.:..:.:..:..|::...:.
Yeast   777 DVIGLFDWKDLSVINLEVMVWLTKGLIMQNSLESSEIAKKFIDLLSNEEIGSLVSKLFEVFVMDI 841

  Fly   781 PELDL-------PVVKFLYKQKLFHTIMGKMGSKLAN------YCVHHLKAFVYVLKATPQAVIK 832
            ..|..       ..||.|||||.|..|...:.|...|      .| ::|.|...|||.||...:.
Yeast   842 SSLKKFKGISWNNNVKILYKQKFFGDIFQTLVSNYKNTVDMTIKC-NYLTALSLVLKHTPSQSVG 905

  Fly   833 LNIEQLGPLLFKSLEEHNEAQSLCIALGICEKFVAQQDTYFQGHLAHLIPSCLELSKYKAQHTMQ 897
            ..|..|.|||.::| :..:.:....||...:....:..|....|::.::|..|.||.....:::.
Yeast   906 PFINDLFPLLLQAL-DMPDPEVRVSALETLKDTTDKHHTLITEHVSTIVPLLLSLSLPHKYNSVS 969

  Fly   898 VRIAALQLLYDVTK-YPTFVLLPHKVDVTLALAAALDDPKRLVRNTAVKARNAWYLVG 954
            ||:.|||||..:|. .|....|.::.||..||...|.|.||::|...|..|..:|.:|
Yeast   970 VRLIALQLLEMITTVVPLNYCLSYQDDVLSALIPVLSDKKRIIRKQCVDTRQVYYELG 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mms19	NP_649519.1	MMS19_N	44..302	CDD:433995	71/265 (27%)
		MMS19_C	<610..910	CDD:463594	80/356 (22%)
MET18	NP_012138.1	MMS19_N	49..313	CDD:433995	71/265 (27%)
		MMS19_C	577..982	CDD:463594	93/435 (21%)