DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mms19 and MET18

DIOPT Version :9

Sequence 1:	NP_649519.1	Gene:	Mms19 / 40626	FlyBaseID:	FBgn0037301	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001318759.1	Gene:	MET18 / 834864	AraportID:	AT5G48120	Length:	1134	Species:	Arabidopsis thaliana

Alignment Length:	1151	Identity:	263/1151 - (22%)
Similarity:	452/1151 - (39%)	Gaps:	260/1151 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KSDQKLVNSATQIAKDLTAKAYDISALAEALGFALSSPDMEERVAGTNLLSAVLIALPQDLLQER 78
            :|..:..:|...||..|...:..|:.|...:...|::.|...|..|..||:.:|..|....|.:.
plant    20 RSSSQQDDSLKAIASSLENDSLSITQLVREMEMYLTTTDNLVRARGILLLAEILDCLKAKPLNDT 84

  Fly    79 QLEFLSTFYMDRLRDHHNVMPAIIDGIDALVHMK----ALPRAQIPQILQSFFEHTTCQSQTRSD 139
            .:..|..|:.::|.|...:..|:: |..||:..|    .:....:..:.:|..::...|:....:
plant    85 IVHTLVGFFSEKLADWRAMCGALV-GCLALLKRKDVAGVVTDIDVQAMAKSMIQNVQVQALALHE 148

  Fly   140 RTKLFHIFQYLTENFQDELQAMAGDFVYGLINSIDGERDPRNLDIIFSFM----PEFLS-TYPLL 199
            |...|.:.:.|.:...:.:..|....||.:..:||||:||:.|.|:|..:    |.|.| :.||.
plant   149 RKLAFELLECLLQQHSEAILTMGDLLVYAMCEAIDGEKDPQCLMIVFHLVELLAPLFPSPSGPLA 213

  Fly   200 HLAEEMFEIFACYFPIDFNPSKQDPAAITRDELSKKLTNCLVANNEFAEGTVVLAIEKLESELLV 264
            ..|.::||:..||||:.|..:|.|.|.|.|::||:.|...:.:...|....:.|.:|||.|.|.|
plant   214 SDASDLFEVIGCYFPLHFTHTKDDEANIRREDLSRGLLLAISSTPFFEPYAIPLLLEKLSSSLPV 278

  Fly   265 AKLDSIELLHQAAVKFPPSVLEPHFDQIWQALKTETF-----------------PGNDNEEILKA 312
            ||:||::.|...|:|:....::.|:..:|.||| :||                 ||.:..||.:.
plant   279 AKVDSLKCLKDCALKYGVDRMKKHYGALWSALK-DTFYSSTGTHLSFAIESLTSPGFEMNEIHRD 342

  Fly   313 SLKALSALLE--------------------------RAAHIPD------------ISHSYQSSI- 338
            ::..|..|::                          :...:||            :|.|.::|:
plant   343 AVSLLQRLVKQDISFLGFVVDDTRINTVFDTIYRYPQYKEMPDPSKLEVLVISQILSVSAKASVQ 407

  Fly   339 ----------------LG---------VILPHLSDVNQRLFHPATG--IALVCVSGDAPYAADK- 375
                            ||         |:....|.|:.||:|....  |.|:..|.|.....::
plant   408 SCNIIFEAIFFRLMNTLGIVEKTSTGDVVQNGNSTVSTRLYHGGLHLCIELLAASKDLILGFEEC 472

  Fly   376 ------------ILNSFLLKL------QAADASSEQRIKIYYIVSQVYKLSALRGSLQKLDTTIR 422
                        ::.||.:.|      ....::.:..:.:|..|..:..:...||....:..|..
plant   473 SPTSGCANSGCSMVKSFSVPLIQVFTSAVCRSNDDSVVDVYLGVKGLLTMGMFRGGSSPVSRTEF 537

  Fly   423 ESVQDDVIASLRLIEQEEFDAKKEDLELQKAALSVLNESAPLLNEKQRALIYKALVQLVSHPSID 487
            |::   ::....:|..:  ..|....||...||..:.......:|..:|:.|.::|       :|
plant   538 ENI---LVTLTSIITAK--SGKTVVWELALKALVCIGSFIDRYHESDKAMSYMSIV-------VD 590

  Fly   488 IDFTTLTVSLGALQPVEVQSNFIDVCVRNFEIFSTFVKRKIYTNLLPLMPQIAFTQRILDLVMTQ 552
             :..:|..|.....|.::      :.....|:.||..|   |...:....:.||...:.|..:..
plant   591 -NLVSLACSSHCGLPYQM------ILEATSEVCSTGPK---YVEKMVQGLEEAFCSSLSDFYVNG 645

  Fly   553 TFN--DTTAEPVRLLALEALNKLLLLADQRFIVDVQQESNLLH------KLIEL---------GQ 600
            .|.  |..::.::.|.    ||||....:   :| ..|..|:|      |.||.         |:
plant   646 NFESIDNCSQLLKCLT----NKLLPRVAE---ID-GLEQLLVHFAISMWKQIEFCGVFSCDFNGR 702

  Fly   601 KTEGLSMQSLEQIAGALSRITQQLPLSEQSAIVSE-YLPGLNLSQSADLYITKGLLGYLHKDITL 664
            :....:|.::.|:.|.....:|...:.:..::||. .||.:.     .:.:|...|..|.:|::.
plant   703 EFVEAAMTTMRQVVGIALVDSQNSIIQKAYSVVSSCTLPAME-----SIPLTFVALEGLQRDLSS 762

  Fly   665 DDHFERLLTDLTQL----SLNSDNEQLRVIAHHLLC--------------SMVNKMESNP----- 706
            .|  |.:|:....:    |.::.....:.:.|.||.              |||||:.|..
plant   763 RD--ELILSLFASVIIAASPSASIPDAKSLIHLLLVTLLKGYIPAAQALGSMVNKLGSGSGGTNT 825

  Fly   707 ---------------ANLRKVKKITEQLKVAIKKG------------------DVRAVEILAWVG 738
                           |:....|||:......|..|                  ..||:..|||:|
plant   826 SRDCSLEEACAIIFHADFASGKKISSNGSAKIIVGSETTMSKICLGYCGSLDLQTRAITGLAWIG 890

  Fly   739 KGLVVAGFDEAADVVGDLSDLLK---------HPSLSTAAALGFDIIAAEYPELDL-----PVVK 789
            |||::.|.:...::...|.:.||         |||....||..|.||.:: .|:.|     .|::
plant   891 KGLLMRGNERVNEIALVLVECLKSNNCSGHALHPSAMKHAADAFSIIMSD-SEVCLNRKFHAVIR 954

  Fly   790 FLYKQKLFHTIMGKMGSKLAN------YCVHHLKAFVYVLKATPQAVIKLNIEQLGPLLFK---- 844
            .||||:.|.||:..:.|.:.|      ..:.|: |..:|:...|..||..|.::|.||:.:
plant   955 PLYKQRCFSTIVPILESLIMNSQTSLSRTMLHV-ALAHVISNVPVTVILDNTKKLQPLILEGLSV 1018

  Fly   845 ----SLEEHNEAQSLCIALGICEKFVAQQDTYFQGHLAHLIPSCL-ELSKYKAQHTMQVRIAALQ 904
                |:|:......|.:..|.......||..   ...||:|..|| :|:.|  .|.|.||..::|
plant  1019 LSLDSVEKETLFSLLLVLSGTLTDTKGQQSA---SDNAHIIIECLIKLTSY--PHLMVVRETSIQ 1078

  Fly   905 LLYDVTKYPTFVLLPHKVDVTLALAAALDDPKRLVRNTAVKARNAW 950
            .|..:.:.|...:.|.:.:|..|:..:||||||.||..|::.|.||
plant  1079 CLVALLELPHRRIYPFRREVLQAIEKSLDDPKRKVREEAIRCRQAW 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mms19	NP_649519.1	MMS19_N	44..301	CDD:291186	76/265 (29%)
Mms19	NP_649519.1	MMS19_C	<658..887	CDD:289245	75/313 (24%)
MET18	NP_001318759.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	114	1.000	Domainoid score	I2012
eggNOG	1	0.900	-	-		E1_KOG1967
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	208	1.000	Inparanoid score	I1267
OMA	1	1.010	-	-		QHG55367
OrthoDB	1	1.010	-	-		D944339at2759
OrthoFinder	1	1.000	-	-		FOG0003902
OrthoInspector	1	1.000	-	-		oto3733
orthoMCL	1	0.900	-	-		OOG6_102900
Panther	1	1.100	-	-	LDO	PTHR12891
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2685
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.930