Protein Alignment Mms19 and Mms19

DIOPT Version :10

• Sequence 1: NP_649519.1
• Gene: Mms19 / 40626
• FlyBaseID: FBgn0037301
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: NP_082428.1
• Gene: Mms19 / 72199
• MGIID: 1919449
• Length: 1031
• Species: Mus musculus
• Alignment Length: 1051
• Identity: 286/1051 - (27%)
• Similarity: 460/1051 - (43%)
• Gaps: 171/1051 - (16%)

  Fly    23 ATQIAKDLTAKAYDISALAEALGFALSSPDMEERVAGTNLLSAVLIALPQDLLQERQLEFLSTFY 87
            |.|:|.|:.:..|.:..:.||||.:|.:.:...|..|..|||.||:.. ..||.|:::..|..||
Mouse    33 ADQVAADVKSGGYTVLQVVEALGSSLENAEPRTRARGAQLLSQVLLQC-HSLLSEKEVVHLILFY 96

  Fly    88 MDRLRDHHNVMPAIIDGIDALVHMKALPRAQIPQILQSFFEHTTCQSQTRSDRTKLFHIFQYLTE 152
            .:||:|||.|:|:::.|:.||....|||......:|::.|:....||..:.||..:|.|......
Mouse    97 ENRLKDHHLVVPSVLQGLRALSMSVALPPGLAVSVLKAIFQEVHVQSLLQVDRHTVFSIITNFMR 161

  Fly   153 NFQDELQAMAGDFVYGLINSIDGERDPRNLDIIFSFMPEFLS-TYPLLHLAEEMFEIFACYFPID 216
            :.::||:.:..||.:|.|..:|||:|||||.:.|..:.:.:| .|.|....||:||:.:||||||
Mouse   162 SREEELKGLGADFTFGFIQVMDGEKDPRNLLLAFRIVHDLISKDYSLGPFVEELFEVTSCYFPID 226

  Fly   217 FNPSKQDPAAITRDELSKKLTNCLVANNEFAEGTVVLAIEKLESELLVAKLDSIELLHQAAVKFP 281
            |.|...||..|.|::|...|...|.:...|||..:.|.|||::||:|.|||||::.|:.....:.
Mouse   227 FTPPPNDPYGIQREDLILSLRAVLASTPRFAEFLLPLLIEKVDSEILSAKLDSLQTLNACCAVYG 291

  Fly   282 PSVLEPHFDQIWQALKTETFPGNDNEEILK---ASLKALSALLERA---AHIPDISHSYQSSILG 340
            ...|:.....:|.:::.|.|. ..:|.:..   |:|.:|:|.|..:   |...|:..|:.|:||.
Mouse   292 QKELKDFLPSLWASIRREVFQ-TASERVEAEGLAALHSLTACLSCSVLRADAEDLLGSFLSNILQ 355

  Fly   341 VILPHLSDVNQRLFHPATGIALVCVSGDAPYAADKILNS---FLLKLQAADASSEQRIKIYYIVS 402
            ....||.:.:.:|..|:..: |...:|.:..|.:.:.::   .||:.....:.|.||..|..::.
Mouse   356 DCRHHLCEPDMKLVWPSAKL-LQAAAGASARACEHLTSNVLPLLLEQFHKHSQSNQRRTILEMIL 419

  Fly   403 QVYKLSALRGSLQKLDTTIRESVQDDV-------------------IASLRLIEQEEFDAKKEDL 448
            ...||.. :.|.:..|.....|.:|.:                   |.:|.::..:......|||
Mouse   420 GFLKLQQ-KWSYEDRDERPLSSFKDQLCSLVFMALTDPSTQLQLVGIRTLTVLGAQPGLLSAEDL 483

  Fly   449 ELQKAALSVLNESAPLLNEKQRALIYKALVQLVSHPSIDIDFTTLTVSLGA----LQP---VEVQ 506
            ||....|..|.    .|.|..::....||         :...|..|:..||    |.|   .|:.
Mouse   484 ELAVGHLYRLT----FLEEDSQSCRVAAL---------EASGTLATLYPGAFSRHLLPKLAEELH 535

  Fly   507 SNFIDV--------CVRNFE----IFSTFVKRKIYTNLLPLMPQIAFTQRILDLVMTQTFNDTTA 559
            ....||        |.|:|.    :.:......|....|||:.|        .|......|..|.
Mouse   536 KGESDVARADGPTKCSRHFRCLQALSAVSTHPSIVKETLPLLLQ--------HLCQANKGNMVTE 592

  Fly   560 EPVRLLALEALNKLLLLADQ---------------RFIVDVQ-----QESNLLHKLIELGQKTEG 604
            ....:...::|.::.....|               .|.:.||     :||::|.|::     .|.
Mouse   593 SSEVVAVCQSLQQVAEKCQQDPESYWYFHKTAVPCLFALAVQASMPEKESSVLRKVL-----LED 652

  Fly   605 LSMQSLEQIAG-ALSRITQQLPLSEQSAIVSEYLPGLNLSQSADLYITKGLLGYLHKDITLDDHF 668
            ..:.:|..:.| |.:.::.:|.....:.||..:|.| |.|             :|.:: :..|.|
Mouse   653 EVLAALASVIGTATTHLSPELAAQSVTCIVPLFLDG-NTS-------------FLPEN-SFPDQF 702

  Fly   669 E----------RLLTDLT----QLSLNSDNEQLRVIAHHLL---CSMVNKMESNPAN------LR 710
            :          ||:..||    .|..|.:..||..:...||   |.......|..|.      |.
Mouse   703 QPFQDGSSGQRRLVALLTAFVCSLPRNVEIPQLNRLMRELLKQSCGHSCPFSSTAATKCFAGLLN 767

  Fly   711 KV---KKITEQLKVAIKKGDV-----------RAVEILAWVGKGLVVAGFDEAADVVGDLSDLLK 761
            |.   :::.|.|::|:  |.|           :|..:|.||.|.||:.....:|.:...|..||.
Mouse   768 KQPPGQQLEEFLQLAV--GTVEAGLASESSRDQAFTLLLWVTKALVLRYHPLSACLTTRLMGLLS 830

  Fly   762 HPSLSTAAALGFDIIAAEYPEL-------DLPVVKFLYKQKLFHTIMGKM--GSKLANYCV--HH 815
            .|.|..|||.||.::.::..::       |   |:.:::|:.|...:..:  |...|...|  ::
Mouse   831 DPELGCAAADGFSLLMSDCTDVLTRAGHAD---VRIMFRQRFFTDNVPALVQGFHAAPQDVKPNY 892

  Fly   816 LKAFVYVLKATPQAVIKLNIEQLGPLLFKSLEEHNEAQSLCIALGICEKFVAQQDTYFQGHLAHL 880
            ||...:||...|:.|:...:..|..||.::|...:....|. .|...:..:.:.......|:..|
Mouse   893 LKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCPDSVVQLS-TLSCLQPLLLEAPQIMSLHVDTL 956

  Fly   881 IPSCLELSKYKAQHTMQVRIAALQLLYDVTKYPTFVLLPHKVDVTLALAAALDDPKRLVRNTAVK 945
            :...|.||   :.::|.|||||||.::.:|:.||.||||:|..|..|||..|||.|||||..||.
Mouse   957 VTKFLNLS---SSYSMAVRIAALQCMHALTRLPTSVLLPYKSQVIRALAKPLDDKKRLVRKEAVS 1018

  Fly   946 ARNAWYLVGAP 956
            ||..|:|:|:|
Mouse  1019 ARGEWFLLGSP 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mms19	NP_649519.1	MMS19_N	44..302	CDD:433995	93/258 (36%)
		MMS19_C	<610..910	CDD:463594	83/348 (24%)
Mms19	NP_082428.1	MMS19_N	54..312	CDD:433995	93/258 (36%)
		MMS19_C	556..983	CDD:463594	124/480 (26%)
		HEAT 1	867..905		6/37 (16%)
		HEAT 2	909..947		21/37 (57%)
		HEAT 3	950..988		9/17 (53%)
		HEAT 4	991..1029