DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mms19 and Mms19

DIOPT Version :9

Sequence 1:	NP_649519.1	Gene:	Mms19 / 40626	FlyBaseID:	FBgn0037301	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_082428.1	Gene:	Mms19 / 72199	MGIID:	1919449	Length:	1031	Species:	Mus musculus

Alignment Length:	1051	Identity:	286/1051 - (27%)
Similarity:	460/1051 - (43%)	Gaps:	171/1051 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ATQIAKDLTAKAYDISALAEALGFALSSPDMEERVAGTNLLSAVLIALPQDLLQERQLEFLSTFY 87
            |.|:|.|:.:..|.:..:.||||.:|.:.:...|..|..|||.||:.. ..||.|:::..|..||
Mouse    33 ADQVAADVKSGGYTVLQVVEALGSSLENAEPRTRARGAQLLSQVLLQC-HSLLSEKEVVHLILFY 96

  Fly    88 MDRLRDHHNVMPAIIDGIDALVHMKALPRAQIPQILQSFFEHTTCQSQTRSDRTKLFHIFQYLTE 152
            .:||:|||.|:|:::.|:.||....|||......:|::.|:....||..:.||..:|.|......
Mouse    97 ENRLKDHHLVVPSVLQGLRALSMSVALPPGLAVSVLKAIFQEVHVQSLLQVDRHTVFSIITNFMR 161

  Fly   153 NFQDELQAMAGDFVYGLINSIDGERDPRNLDIIFSFMPEFLS-TYPLLHLAEEMFEIFACYFPID 216
            :.::||:.:..||.:|.|..:|||:|||||.:.|..:.:.:| .|.|....||:||:.:||||||
Mouse   162 SREEELKGLGADFTFGFIQVMDGEKDPRNLLLAFRIVHDLISKDYSLGPFVEELFEVTSCYFPID 226

  Fly   217 FNPSKQDPAAITRDELSKKLTNCLVANNEFAEGTVVLAIEKLESELLVAKLDSIELLHQAAVKFP 281
            |.|...||..|.|::|...|...|.:...|||..:.|.|||::||:|.|||||::.|:.....:.
Mouse   227 FTPPPNDPYGIQREDLILSLRAVLASTPRFAEFLLPLLIEKVDSEILSAKLDSLQTLNACCAVYG 291

  Fly   282 PSVLEPHFDQIWQALKTETFPGNDNEEILK---ASLKALSALLERA---AHIPDISHSYQSSILG 340
            ...|:.....:|.:::.|.|. ..:|.:..   |:|.:|:|.|..:   |...|:..|:.|:||.
Mouse   292 QKELKDFLPSLWASIRREVFQ-TASERVEAEGLAALHSLTACLSCSVLRADAEDLLGSFLSNILQ 355

  Fly   341 VILPHLSDVNQRLFHPATGIALVCVSGDAPYAADKILNS---FLLKLQAADASSEQRIKIYYIVS 402
            ....||.:.:.:|..|:..: |...:|.:..|.:.:.::   .||:.....:.|.||..|..::.
Mouse   356 DCRHHLCEPDMKLVWPSAKL-LQAAAGASARACEHLTSNVLPLLLEQFHKHSQSNQRRTILEMIL 419

  Fly   403 QVYKLSALRGSLQKLDTTIRESVQDDV-------------------IASLRLIEQEEFDAKKEDL 448
            ...||.. :.|.:..|.....|.:|.:                   |.:|.::..:......|||
Mouse   420 GFLKLQQ-KWSYEDRDERPLSSFKDQLCSLVFMALTDPSTQLQLVGIRTLTVLGAQPGLLSAEDL 483

  Fly   449 ELQKAALSVLNESAPLLNEKQRALIYKALVQLVSHPSIDIDFTTLTVSLGA----LQP---VEVQ 506
            ||....|..|.    .|.|..::....||         :...|..|:..||    |.|   .|:.
Mouse   484 ELAVGHLYRLT----FLEEDSQSCRVAAL---------EASGTLATLYPGAFSRHLLPKLAEELH 535

  Fly   507 SNFIDV--------CVRNFE----IFSTFVKRKIYTNLLPLMPQIAFTQRILDLVMTQTFNDTTA 559
            ....||        |.|:|.    :.:......|....|||:.|        .|......|..|.
Mouse   536 KGESDVARADGPTKCSRHFRCLQALSAVSTHPSIVKETLPLLLQ--------HLCQANKGNMVTE 592

  Fly   560 EPVRLLALEALNKLLLLADQ---------------RFIVDVQ-----QESNLLHKLIELGQKTEG 604
            ....:...::|.::.....|               .|.:.||     :||::|.|::     .|.
Mouse   593 SSEVVAVCQSLQQVAEKCQQDPESYWYFHKTAVPCLFALAVQASMPEKESSVLRKVL-----LED 652

  Fly   605 LSMQSLEQIAG-ALSRITQQLPLSEQSAIVSEYLPGLNLSQSADLYITKGLLGYLHKDITLDDHF 668
            ..:.:|..:.| |.:.::.:|.....:.||..:|.| |.|             :|.:: :..|.|
Mouse   653 EVLAALASVIGTATTHLSPELAAQSVTCIVPLFLDG-NTS-------------FLPEN-SFPDQF 702

  Fly   669 E----------RLLTDLT----QLSLNSDNEQLRVIAHHLL---CSMVNKMESNPAN------LR 710
            :          ||:..||    .|..|.:..||..:...||   |.......|..|.      |.
Mouse   703 QPFQDGSSGQRRLVALLTAFVCSLPRNVEIPQLNRLMRELLKQSCGHSCPFSSTAATKCFAGLLN 767

  Fly   711 KV---KKITEQLKVAIKKGDV-----------RAVEILAWVGKGLVVAGFDEAADVVGDLSDLLK 761
            |.   :::.|.|::|:  |.|           :|..:|.||.|.||:.....:|.:...|..||.
Mouse   768 KQPPGQQLEEFLQLAV--GTVEAGLASESSRDQAFTLLLWVTKALVLRYHPLSACLTTRLMGLLS 830

  Fly   762 HPSLSTAAALGFDIIAAEYPEL-------DLPVVKFLYKQKLFHTIMGKM--GSKLANYCV--HH 815
            .|.|..|||.||.::.::..::       |   |:.:::|:.|...:..:  |...|...|  ::
Mouse   831 DPELGCAAADGFSLLMSDCTDVLTRAGHAD---VRIMFRQRFFTDNVPALVQGFHAAPQDVKPNY 892

  Fly   816 LKAFVYVLKATPQAVIKLNIEQLGPLLFKSLEEHNEAQSLCIALGICEKFVAQQDTYFQGHLAHL 880
            ||...:||...|:.|:...:..|..||.::|...:....|. .|...:..:.:.......|:..|
Mouse   893 LKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCPDSVVQLS-TLSCLQPLLLEAPQIMSLHVDTL 956

  Fly   881 IPSCLELSKYKAQHTMQVRIAALQLLYDVTKYPTFVLLPHKVDVTLALAAALDDPKRLVRNTAVK 945
            :...|.||   :.::|.|||||||.::.:|:.||.||||:|..|..|||..|||.|||||..||.
Mouse   957 VTKFLNLS---SSYSMAVRIAALQCMHALTRLPTSVLLPYKSQVIRALAKPLDDKKRLVRKEAVS 1018

  Fly   946 ARNAWYLVGAP 956
            ||..|:|:|:|
Mouse  1019 ARGEWFLLGSP 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mms19	NP_649519.1	MMS19_N	44..301	CDD:291186	93/257 (36%)
Mms19	NP_649519.1	MMS19_C	<658..887	CDD:289245	63/276 (23%)
Mms19	NP_082428.1	MMS19_N	54..312	CDD:373098	93/258 (36%)
		MMS19_C	528..963	CDD:372125	126/507 (25%)
		HEAT 1	867..905		6/37 (16%)
		HEAT 2	909..947		21/37 (57%)
		HEAT 3	950..988		9/17 (53%)
		HEAT 4	991..1029

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830936
Domainoid	1	1.000	176	1.000	Domainoid score	I3612
eggNOG	1	0.900	-	-		E1_KOG1967
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2711
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55367
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003902
OrthoInspector	1	1.000	-	-		oto93519
orthoMCL	1	0.900	-	-		OOG6_102900
Panther	1	1.100	-	-	LDO	PTHR12891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2685
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760