DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mms19 and mms19

DIOPT Version :9

Sequence 1:	NP_649519.1	Gene:	Mms19 / 40626	FlyBaseID:	FBgn0037301	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001334591.1	Gene:	mms19 / 563643	ZFINID:	ZDB-GENE-120316-2	Length:	1016	Species:	Danio rerio

Alignment Length:	1069	Identity:	278/1069 - (26%)
Similarity:	455/1069 - (42%)	Gaps:	204/1069 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DQKLVNSATQIAKDLTAKAYDISALAEALGFALSSPDMEERVAGTNLLSAVLIALPQDL---LQE 77
            |.|..:::|.:...    .:.:..|.||||.:|:|...:.|..|..|||.||    |:.   |.|
Zfish    21 DSKAADTSTGVKNG----QFTVLQLVEALGVSLTSSQPQTRGRGVQLLSQVL----QECYSGLSE 77

  Fly    78 RQLEFLSTFYMDRLRDHHNVMPAIIDGIDALVHMKALPRAQIPQILQSFFEHTTCQSQTRSDRTK 142
            |::|.|..||.:||:||:.:.|.::.|:.||.....||......||:|.|:....||...::|:.
Zfish    78 REVEVLIAFYENRLKDHYVITPHVLRGLKALAKCSVLPPGSAVSILKSIFQDVHVQSLMVTERSC 142

  Fly   143 LFHIFQYLTENFQDELQAMAGDFVYGLINSIDGERDPRNLDIIFSFMPEFL-STYPLLHLAEEMF 206
            :::|...|.|:.::||:.:..||::|.:.|:|||||||||.:.|......: ..|.|....||:|
Zfish   143 VYNILISLMESREEELKGLGADFIFGFVQSVDGERDPRNLLLAFQVAKNIIYRGYDLGKFVEELF 207

  Fly   207 EIFACYFPIDFNPSKQDPAAITRDELSKKLTNCLVANNEFAEGTVVLAIEKLESELLVAKLDSIE 271
            |:.:|||||||:|...||..||::||...|...|.....|||..:.|.|||::|::..||:||:.
Zfish   208 EVTSCYFPIDFSPPPNDPHGITQEELILSLRAVLTGTPRFAEFLLPLIIEKMDSDVQSAKVDSMH 272

  Fly   272 LL--------HQAAVKFPPSVLEPHFDQIWQALKTETFPGNDNEEILKASLKALSAL---LERAA 325
            .|        |:...:|.|.        :|.:::.|.|. ..:|.:..|.|.|||:|   |.|:.
Zfish   273 TLAACGQTYSHKELAEFLPG--------LWSSIRREVFQ-TASERVESAGLSALSSLVSCLSRSV 328

  Fly   326 HIPDISHSYQSSILGVILP----HLSDVNQRLFHPATGIALVCVSGDAPYAADKI---------L 377
            ...|...|.| ..|.::|.    ||.:.:.:|..|:.  .|:..:..|.|.|..|         |
Zfish   329 LNSDSEDSLQ-VFLNLVLKDCQHHLCEPDLKLVWPSA--KLLQAAAGASYRASLIGTQAVIPALL 390

  Fly   378 NSFLLKLQAAD--------------------ASSEQRIKIYY---IVSQVYK-LSALRGSLQKLD 418
            :.:..:.|.|.                    |..|:.:.:.:   :.:.|:. ||.....||...
Zfish   391 DQYNNRTQCAQRRTLLEVLQGFVQPTPLSRPADGEESVLVAFQQSLCTVVFSALSETSAGLQVTA 455

  Fly   419 TTI------------RESVQDDVIASLRLI-EQEEFDAKKEDLELQKAALSVLNESA------PL 464
            |.:            :..|::.|....||| |:||.......:|. ..:|:.|:..|      |.
Zfish   456 TRVLTALSQQPGLLSQTDVENAVDHLTRLILEEEEAQVSLAVVEC-SGSLAHLHPHAFVSRMIPQ 519

  Fly   465 LNEK---------QRALIYKALVQLVSHPSIDIDFTTLTVSLGALQPVEVQ-------------- 506
            |.||         .|.....||..:.|.||:          :....||.:|
Zfish   520 LKEKILSDECSGAVRRRCVAALASVSSQPSV----------VQESSPVLLQVLTSAHTGCCGFSV 574

  Fly   507 SNFIDVCVRNFEIFSTFVKRKIYTNLLPLMPQIAFTQRILDLVMTQTFNDTTAEPVRLLALEALN 571
            ...|.||:.                    :.:||...|..:.: .|.|:|....  |||.| .|.
Zfish   575 EEVIAVCIS--------------------LQRIAVHARDNEAI-GQFFHDIIIP--RLLGL-TLQ 615

  Fly   572 KLLLLADQRFIVDVQQESNLLHKLIEL------GQKTEGLSMQSLEQIAGALSRITQQLPLSEQS 630
            ..|...|...|..:..|: :|..::.:      ..|.|..|..:.:.::..|...|..||   ::
Zfish   616 AALQSKDSGHISPLTDEA-VLSAIVPVISTACAALKPESASRMAAQAVSLFLDGDTSFLP---EN 676

  Fly   631 AIVSEYLPGLNLSQSAD-------LYITKGLLGYLHKDITLDDHFERLLTDLTQLSLNSDNEQLR 688
            |..|:..|   |...||       :.:....:..|.:.:.:.| .:|||..|..||..|.:....
Zfish   677 AFPSQIQP---LQSQADSRGPSQLVCLLMACVCSLPRSVEIPD-MDRLLVQLEDLSCTSPHLFSY 737

  Fly   689 VIAHHLLCSMVNKMESNPA-NL---RKVKKITEQLKVAIKKGDVRAVEILAWVGKGLVVAGFDEA 749
            ..|...:..:|||..:..| |.   |.:|:::.:|:........:|..:|.||.|.|::.....:
Zfish   738 TFASKCIAGLVNKRPAGAALNAVLDRVLKRVSLELEETSSTHRTQAFTLLIWVAKALLLRYHPLS 802

  Fly   750 ADVVGDLSDLLKHPSLSTAAALGFDIIAAEYPEL---DLPV-VKFLYKQKLFHTIMGKM------ 804
            ..:...|..||...:|.:..|.||.::..:.|::   |... |:.:|:|:.|.....|:
Zfish   803 TALTDKLFSLLSDSALGSLVADGFCVLMNDSPDVLNRDCHADVRIMYRQRFFTENSSKLVQGFNS 867

  Fly   805 GSKLANYCVHHLKAFVYVLKATPQAVIKLNIEQLGPLLFKSLEEHNEAQSLCIALGI------C- 862
            ..:....|  :|||..:::...|:.|....:..|.|||.::|.        |:..|:      |
Zfish   868 AEQAKKSC--YLKALSHIVNNLPREVQLTELPALLPLLLEALS--------CVDQGVQLSTLSCL 922

  Fly   863 EKFVAQQDTYFQGHLAHLIPSCLELSKYKAQHTMQVRIAALQLLYDVTKYPTFVLLPHKVDVTLA 927
            :..:.:........|..|....|.|:...|   |:||:|:|:.::.:::.|..:::|.:..|..|
Zfish   923 QPVLLESPAALNTQLEALFTRLLALTTSPA---MKVRMASLRCVHALSRLPEHMVMPFRARVLKA 984

  Fly   928 LAAALDDPKRLVRNTAVKARNAWYLVGAP 956
            |||.|||.|||||..||.||..|:|:|:|
Zfish   985 LAAPLDDKKRLVRKEAVAARGEWFLLGSP 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mms19	NP_649519.1	MMS19_N	44..301	CDD:291186	95/268 (35%)
Mms19	NP_649519.1	MMS19_C	<658..887	CDD:289245	55/249 (22%)
mms19	NP_001334591.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573852
Domainoid	1	1.000	168	1.000	Domainoid score	I3796
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2933
OMA	1	1.010	-	-		QHG55367
OrthoDB	1	1.010	-	-		D402058at33208
OrthoFinder	1	1.000	-	-		FOG0003902
OrthoInspector	1	1.000	-	-		oto39962
orthoMCL	1	0.900	-	-		OOG6_102900
Panther	1	1.100	-	-	LDO	PTHR12891
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R725
SonicParanoid	1	1.000	-	-		X2685
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.030