DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mms19 and Mms19

DIOPT Version :9

Sequence 1:	NP_649519.1	Gene:	Mms19 / 40626	FlyBaseID:	FBgn0037301	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001258525.1	Gene:	Mms19 / 171124	RGDID:	727890	Length:	1031	Species:	Rattus norvegicus

Alignment Length:	1053	Identity:	281/1053 - (26%)
Similarity:	457/1053 - (43%)	Gaps:	175/1053 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ATQIAKDLTAKAYDISALAEALGFALSSPDMEERVAGTNLLSAVLIALPQDLLQERQLEFLSTFY 87
            |.|:|.|:.:..|.:..:.||||.:|.:|:...|..|..|||.||:.. ..||.|::...|:.||
  Rat    33 ADQVAADVKSGGYTVLQVVEALGSSLENPEPRTRARGIQLLSQVLLQC-HSLLLEKEAVHLTLFY 96

  Fly    88 MDRLRDHHNVMPAIIDGIDALVHMKALPRAQIPQILQSFFEHTTCQSQTRSDRTKLFHIFQYLTE 152
            .:||:|||.|:|:::.|:.||....||||.....:|::.|:....||..:.||..:|.|......
  Rat    97 ENRLKDHHLVVPSVLQGLRALSLSVALPRGLAVSVLKAIFQEVHVQSLLQVDRHTVFSIITNFMR 161

  Fly   153 NFQDELQAMAGDFVYGLINSIDGERDPRNLDIIFSFMPEFLS-TYPLLHLAEEMFEIFACYFPID 216
            :.::||:::..||.:|.|..:|||:|||||.:.|..:.:.:| .|.|....||:||:.:||||||
  Rat   162 SREEELKSLGADFTFGFIQVMDGEKDPRNLLLAFRIVHDLISKDYNLGPFVEELFEVTSCYFPID 226

  Fly   217 FNPSKQDPAAITRDELSKKLTNCLVANNEFAEGTVVLAIEKLESELLVAKLDSIELLHQAAVKFP 281
            |.|...||..|.|::|...|...|.:...|||..:.|.|||::||:|.|||||::.|:.....:.
  Rat   227 FTPPPNDPYGIQREDLILSLRAVLASTPRFAEFLLPLLIEKVDSEILSAKLDSLQTLNACCAVYG 291

  Fly   282 PSVLEPHFDQIWQALKTETFPGNDNEEILK---ASLKALSALLERA---AHIPDISHSYQSSILG 340
            ...|:.....:|.:::.|.|. ..:|.:..   |:|.:|:|.|..:   |...|:.|.:.||||.
  Rat   292 QKELKDFLPSLWASIRREVFQ-TASERVEAEGLAALHSLTACLSCSVLRADAEDLLHPFLSSILQ 355

  Fly   341 VILPHLSDVNQRLFHPATGIALVCVSGDAPYAADKILNS---FLLKLQAADASSEQRIKIYYIVS 402
            ....||.:.:.:|..|:..: |...:|.:..|.:.|.::   .||:.....:.|.||..|..::.
  Rat   356 DCRHHLCEPDMKLVWPSAKL-LQAAAGASARACEHITSNVLPLLLEQFHKHSQSNQRRTILEMIL 419

  Fly   403 QVYKLSALRGSLQKLDTTIRESVQDDV-------------------IASLRLIEQEEFDAKKEDL 448
            ...||.. :.|.:..|.....:.:|.:                   |..|.::..:......|||
  Rat   420 GFLKLQQ-KWSYEDRDERPLSNFKDQLCSLVFMALTDPSTQLQLVGIRMLTVLGAQPDLLSAEDL 483

  Fly   449 ELQKAALSVLNESAPLLNEKQRALIYKALVQLVSHPSIDIDFTTLTVSLGALQPVEVQSNFI--- 510
            ||....|..|:    ||.|..::....||              ..:.||..|.|....|:.:
  Rat   484 ELAVGHLYRLS----LLEEDAQSCRVAAL--------------EASGSLATLYPGAFSSHLLPRL 530

  Fly   511 ---------DV--------CVRNFE----IFSTFVKRKIYTNLLPLMPQ---------------- 538
                     ||        |.|:|.    :.:......|....|||:.|
  Rat   531 AEGLHQGESDVARADGPTKCSRHFRCLQALSAVSTHPDIVKETLPLLLQHLCQAHKGNMITESSE 595

  Fly   539 -IAFTQRILDLVMTQTFND--------TTAEPVRLLALEALNKLLLLADQRFIVDVQQESNLLHK 594
             :|..|. |..|..:...|        .||.|.          |..||.|..:  .::.|::|.|
  Rat   596 VVAVCQS-LQQVAEKCQQDPESYWYFHKTAVPC----------LFALAVQASV--PEKASSVLSK 647

  Fly   595 LIELGQKTEGLSMQSLEQIAG-ALSRITQQLPLSEQSAIVSEYLPGLNLS--------------- 643
            .:     .|...:.:|..:.| |.:.::.:|.....:.||..:|.| |.|
  Rat   648 AL-----LEDEVLAALASVIGTATTHLSPELAAQSVTCIVPLFLDG-NTSFLPENSFPGHFQPFQ 706

  Fly   644 --QSADLYITKGLLGY---LHKDITLDDHFERLLTDLTQLSLNSDNEQLRVIAHHLLCSMVNKME 703
              .|....:...|:.:   |.:::.:.: ..||:.:|.:.|...........|......::||..
  Rat   707 GGSSGQRRLVALLMAFVCSLPRNVEIPE-LTRLMQELLKQSCGHSCPFSSTAASKCFAGLLNKQP 770

  Fly   704 SNPANLRKVKKITEQLKVAIKKGDV---------RAVEILAWVGKGLVVAGFDEAADVVGDLSDL 759
            ..       :::.|.|::::...:.         :|..:|.||.|.||:.....:|.:...|..|
  Rat   771 PG-------QQLDEFLQLSVDTVEAGLASESSRNQAFTLLLWVTKALVLRYHPLSASLTARLMGL 828

  Fly   760 LKHPSLSTAAALGFDIIAAEYPEL-------DLPVVKFLYKQKLFHTIMGKM--GSKLANYCV-- 813
            |..|.|..|||.||.::.::..::       |   |:.:::|:.|...:..:  |...|...|
  Rat   829 LSDPELGCAAADGFSLLMSDCTDVLTRAGHAD---VRIMFRQRFFTDNVPALVQGFHAAPQDVKP 890

  Fly   814 HHLKAFVYVLKATPQAVIKLNIEQLGPLLFKSLEEHNEAQSLCIALGICEKFVAQQDTYFQGHLA 878
            ::||...:||...|:.|:...:..|..||.::|...:....|. .|...:..:.:.......|:.
  Rat   891 NYLKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCPDSVVQLS-TLSCLQPLLLEAPQIMSLHVD 954

  Fly   879 HLIPSCLELSKYKAQHTMQVRIAALQLLYDVTKYPTFVLLPHKVDVTLALAAALDDPKRLVRNTA 943
            .|:...|.||   :.|:|.|||||||.::.:|:.||.||||.|..|..|||..|||.|||||..|
  Rat   955 TLVTKFLNLS---SSHSMAVRIAALQCMHALTRLPTSVLLPFKSQVIRALAKPLDDKKRLVRKEA 1016

  Fly   944 VKARNAWYLVGAP 956
            |.||..|:|:|:|
  Rat  1017 VSARGEWFLLGSP 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mms19	NP_649519.1	MMS19_N	44..301	CDD:291186	95/257 (37%)
Mms19	NP_649519.1	MMS19_C	<658..887	CDD:289245	50/248 (20%)
Mms19	NP_001258525.1	MMS19_N	54..312	CDD:291186	95/258 (37%)
Mms19	NP_001258525.1	MMS19_C	555..963	CDD:289245	112/456 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334644
Domainoid	1	1.000	181	1.000	Domainoid score	I3385
eggNOG	1	0.900	-	-		E1_KOG1967
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	309	1.000	Inparanoid score	I2532
OMA	1	1.010	-	-		QHG55367
OrthoDB	1	1.010	-	-		D402058at33208
OrthoFinder	1	1.000	-	-		FOG0003902
OrthoInspector	1	1.000	-	-		oto97059
orthoMCL	1	0.900	-	-		OOG6_102900
Panther	1	1.100	-	-	LDO	PTHR12891
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2685
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.810