DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vps37B and vps-37

DIOPT Version :9

Sequence 1:	NP_001246926.1	Gene:	Vps37B / 40624	FlyBaseID:	FBgn0037299	Length:	214	Species:	Drosophila melanogaster
Sequence 2:	NP_504474.1	Gene:	vps-37 / 178944	WormBaseID:	WBGene00016990	Length:	234	Species:	Caenorhabditis elegans

Alignment Length:	214	Identity:	63/214 - (29%)
Similarity:	103/214 - (48%)	Gaps:	26/214 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ATITPMCHEELKELLNDDDKLDEKVDEVLQV--LRTQKTSVFEDNRSRAERNIEREPQIIELRGQ 73
            |.:..|.:|:|..||:||..|:..:..:.||  :.|.|.|....|:|.||.|:.::|:|...:.|
Worm    20 ANLRNMTNEQLISLLDDDALLESIIVNLPQVRSMPTDKESALAANKSLAEWNLAQKPRIDAAKTQ 84

  Fly    74 LAELSEDGRTRCSSVQEKLSQLKEKSGGVGLETALALLQTAASESEEQTEEMVKKFNDSDIGVED 138
            ..:|.:..:.....|....|||...|....|:|..:|:|.||.|:::..|.:..:|.:.:|.||.
Worm    85 TVDLYDQVKKLQGEVAVLKSQLDSVSSSKSLDTTSSLMQVAAQEADDDAEALFTQFENGEISVEI 149

  Fly   139 FLDAFLPIRRTMHLRRLKAEKMQELMRKQRQG---------------PGPNTS--LPAYGNVP-S 185
            ||..|...:...|||::|::::..|:|:|...               ||..|.  :|..||:. .
Worm   150 FLKQFKDKKTIAHLRKIKSDRLAALLREQTYSSYAQPTVPPPMPHAQPGYPTGNHMPGIGNIQFG 214

  Fly   186 SGF--YP----ASGGSAPY 198
            ||:  ||    .|.|..|:
Worm   215 SGYSGYPNISQPSAGRHPF 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps37B	NP_001246926.1	PABP	<16..42	CDD:295409	10/27 (37%)
Vps37B	NP_001246926.1	Mod_r	19..153	CDD:284587	42/135 (31%)
vps-37	NP_504474.1	Mod_r	23..167	CDD:369259	45/143 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167183
Domainoid	1	1.000	71	1.000	Domainoid score	I6193
eggNOG	1	0.900	-	-		E1_KOG3270
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I3751
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45937
OrthoDB	1	1.010	-	-		D1197293at2759
OrthoFinder	1	1.000	-	-		FOG0003711
OrthoInspector	1	1.000	-	-		oto17973
orthoMCL	1	0.900	-	-		OOG6_107562
Panther	1	1.100	-	-	LDO	PTHR13678
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5541
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.800