DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vps37B and Vps37c

DIOPT Version :9

Sequence 1:	NP_001246926.1	Gene:	Vps37B / 40624	FlyBaseID:	FBgn0037299	Length:	214	Species:	Drosophila melanogaster
Sequence 2:	NP_001100933.1	Gene:	Vps37c / 108348178	RGDID:	11384366	Length:	353	Species:	Rattus norvegicus

Alignment Length:	241	Identity:	66/241 - (27%)
Similarity:	115/241 - (47%)	Gaps:	47/241 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EELKELLNDDD---KLDEKVDEVLQVLRTQKTSVFEDNRSRAERNIEREPQIIELRGQLAELSED 80
            :||:|:.||.:   :|..:..|| |.|:.::......|||.||:|:|.:..:...|..|::..::
  Rat    10 QELEEMQNDPEAIARLALESPEV-QDLQLEREMALATNRSLAEQNLEFQGPLEISRSNLSDKYQE 73

  Fly    81 GRTRCSSVQEKLSQLKEKSGGVGLETALALLQTAASESEEQTEEMVKKFNDSDIGVEDFLDAFLP 145
            .|......||:.::|::.|..:...|.|.|||....:.||::|.|.:||.:.::.:|.||::|..
  Rat    74 LRKLVERCQEQKAKLEKFSSALQPGTLLDLLQIEGMKIEEESEAMAEKFLEGEVPLETFLESFSS 138

  Fly   146 IRRTMHLRRLKAEKMQELMRKQR------------------------------QGPGPNTSLP-- 178
            :|..:||||::.||:|:::|:.|                              |.|.|:...|
  Rat   139 MRTLLHLRRVRVEKLQDVVRRPRALPELAGDAPPKRPPPPRPAPQAAPPETEEQTPQPSVVTPYP 203

  Fly   179 -AYGNVPSSGFYPASGGS---APYPIM-------GPLMPMPPPSRP 213
             .|...|.....|.:.|:   ||:|::       |||.|..|..:|
  Rat   204 LPYSPSPGLPVGPTAQGALQPAPFPVVTQPSSYGGPLGPSYPSPQP 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps37B	NP_001246926.1	PABP	<16..42	CDD:295409	9/25 (36%)
Vps37B	NP_001246926.1	Mod_r	19..153	CDD:284587	41/136 (30%)
Vps37c	NP_001100933.1	Mod_r	5..149	CDD:399880	44/139 (32%)
Vps37c	NP_001100933.1	PHA03247	<194..351	CDD:223021	16/56 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353696
Domainoid	1	1.000	82	1.000	Domainoid score	I8215
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	103	1.000	Inparanoid score	I4859
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1197293at2759
OrthoFinder	1	1.000	-	-		FOG0003711
OrthoInspector	1	1.000	-	-		otm44440
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13678
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.000