DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sccpdh1 and SCCPDH

DIOPT Version :9

Sequence 1:	NP_649517.1	Gene:	Sccpdh1 / 40623	FlyBaseID:	FBgn0037298	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_057086.2	Gene:	SCCPDH / 51097	HGNCID:	24275	Length:	429	Species:	Homo sapiens

Alignment Length:	436	Identity:	172/436 - (39%)
Similarity:	257/436 - (58%)	Gaps:	33/436 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VIIFGASGFTGKYTVFEA----VTVLRGLR--WGIAGRNREKLEAVLKEMGAKAKKDL--SQVPI 64
            :::||||||||::...|.    |...|..|  |.:|||:||||:.||::...|..:..  |:|.|
Human    10 LVVFGASGFTGQFVTEEVAREQVDPERSSRLPWAVAGRSREKLQRVLEKAALKLGRPTLSSEVGI 74

  Fly    65 FIADVNDQASLLEMAKKCRIVVNTAGPYRFHGENVVKCCIESGTHHVDVSGEPQYMETMQLRYDQ 129
            .|.|:.:.|||.||||:..:|:|..|||||:||.|:|.|||:|...:|:|||||::|.|||:|.:
Human    75 IICDIANPASLDEMAKQATVVLNCVGPYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHE 139

  Fly   130 LAREKGVYVVSACGFDSIPADMGVVFVEKNFDGVVNSVETFLETGIKEGGSGGGTAGLNYGTWES 194
            .|.:||||::.:.||||||||:||::.....:|.:.:||:||.  |..|..|   ..::.|||:|
Human   140 KAADKGVYIIGSSGFDSIPADLGVIYTRNKMNGTLTAVESFLT--IHSGPEG---LSIHDGTWKS 199

  Fly   195 AVYGLAHSDELRGIRKQIYPQRLPRFYPFLKPRPLVFRSTEVDKVCLPFPGSDRSVVMRSQRFLY 259
            |:||......||.:|.....:.:|...|.||.|..:....|:....:||.|||.|||.|:||:||
Human   200 AIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLY 264

  Fly   260 DQDKKRPVQMQAYVGFSSWLVAGGV-----IFFATIFGL-LSKFKLGRTLLLNYPGLFSGGLASR 318
            :..::.|||..|||      ..||:     :.||.:|.| ..:|.:||.||:.:|..||.|..|:
Human   265 ENLEESPVQYAAYV------TVGGITSVIKLMFAGLFFLFFVRFGIGRQLLIKFPWFFSFGYFSK 323

  Fly   319 SGPSEESMERTYFKMTFKASGWLKSDRLAESSNQYTESPTKTLMVRVSGMNPGYGATCVAVLSAA 383
            .||:::.::...|.:||...|:      ::.:......|...:..:|.|...||.||.:|::.||
Human   324 QGPTQKQIDAASFTLTFFGQGY------SQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAA 382

  Fly   384 LTILRESDKMPSTGGVLPPAAAFSKTGLISELEKHDHGIKFEILAN 429
            :|:|.::..:|..|||..|.||||||.||..|.|  |||:|.::::
Human   383 MTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNK--HGIEFSVISS 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sccpdh1	NP_649517.1	COG3268	7..426	CDD:225807	172/431 (40%)
Sccpdh1	NP_649517.1	Sacchrp_dh_NADP	8..139	CDD:281434	66/138 (48%)
SCCPDH	NP_057086.2	COG3268	1..421	CDD:225807	171/429 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155286
Domainoid	1	1.000	176	1.000	Domainoid score	I3623
eggNOG	1	0.900	-	-		E1_COG3268
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9334
Inparanoid	1	1.050	300	1.000	Inparanoid score	I2701
Isobase	1	0.950	-	0	Normalized mean entropy	S4069
OMA	1	1.010	-	-		QHG56565
OrthoDB	1	1.010	-	-		D302978at33208
OrthoFinder	1	1.000	-	-		FOG0002586
OrthoInspector	1	1.000	-	-		otm41518
orthoMCL	1	0.900	-	-		OOG6_101495
Panther	1	1.100	-	-	LDO	PTHR12286
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4081
SonicParanoid	1	1.000	-	-		X1697
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750