DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sccpdh1 and Sccpdh2

DIOPT Version :9

Sequence 1:	NP_649517.1	Gene:	Sccpdh1 / 40623	FlyBaseID:	FBgn0037298	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_650190.1	Gene:	Sccpdh2 / 41521	FlyBaseID:	FBgn0038038	Length:	431	Species:	Drosophila melanogaster

Alignment Length:	431	Identity:	302/431 - (70%)
Similarity:	363/431 - (84%)	Gaps:	1/431 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGDRLDVIIFGASGFTGKYTVFEAVTVLRGLRWGIAGRNREKLEAVLKEMGAKAKKDLSQVPIF 65
            |:..:||.||||||||||||||||||:||:||:|||||||:|||::||:|||||:|.||||.||.
  Fly     1 MAAKKLDAIIFGASGFTGKYTVFEAVSVLKGLQWGIAGRNQEKLQSVLREMGAKSKTDLSQTPIV 65

  Fly    66 IADVNDQASLLEMAKKCRIVVNTAGPYRFHGENVVKCCIESGTHHVDVSGEPQYMETMQLRYDQL 130
            |||||::||||||||:|||:|||||||||.||.||:.|||:|||||||||||||||||||||..|
  Fly    66 IADVNNEASLLEMAKRCRILVNTAGPYRFFGERVVRACIEAGTHHVDVSGEPQYMETMQLRYHDL 130

  Fly   131 AREKGVYVVSACGFDSIPADMGVVFVEKNFDGVVNSVETFLETGIKEGGSGGGTAGLNYGTWESA 195
            |:|:||||:||||||||||||||.||||||||||||||.|:..|:|.|..|.|:|.||.||||||
  Fly   131 AKERGVYVISACGFDSIPADMGVTFVEKNFDGVVNSVENFVHLGVKGGTKGTGSAALNTGTWESA 195

  Fly   196 VYGLAHSDELRGIRKQIYPQRLPRFYPFLKPRPLVFRSTEVD-KVCLPFPGSDRSVVMRSQRFLY 259
            ::.:|:..|...||::::|:|||.|:|.||.|..:.|:.||| ||.||||.:|||||||||||||
  Fly   196 IHAIANRSESVAIRRKLFPERLPNFHPALKSRSPLSRAAEVDNKVILPFPETDRSVVMRSQRFLY 260

  Fly   260 DQDKKRPVQMQAYVGFSSWLVAGGVIFFATIFGLLSKFKLGRTLLLNYPGLFSGGLASRSGPSEE 324
            :.:||||||||||:.:.||..|..|:.||:|.|:::||..||.|||.||.:||||:|||.||||.
  Fly   261 ELEKKRPVQMQAYMTYPSWFAASVVVLFASIIGIMAKFSFGRQLLLKYPTVFSGGMASREGPSEA 325

  Fly   325 SMERTYFKMTFKASGWLKSDRLAESSNQYTESPTKTLMVRVSGMNPGYGATCVAVLSAALTILRE 389
            .|||::|:||.||:||.||::|||:::|||..|||||.|||:|.|||||:||||:||.|.|||.|
  Fly   326 RMERSFFRMTMKATGWPKSEKLAETTDQYTSPPTKTLTVRVTGPNPGYGSTCVALLSTAKTILNE 390

  Fly   390 SDKMPSTGGVLPPAAAFSKTGLISELEKHDHGIKFEILANK 430
            |||||.:||||||.|||..|.||||||||:|||||||:|||
  Fly   391 SDKMPGSGGVLPPGAAFRGTSLISELEKHEHGIKFEIVANK 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sccpdh1	NP_649517.1	COG3268	7..426	CDD:225807	295/419 (70%)
Sccpdh1	NP_649517.1	Sacchrp_dh_NADP	8..139	CDD:281434	105/130 (81%)
Sccpdh2	NP_650190.1	COG3268	7..416	CDD:225807	285/408 (70%)
Sccpdh2	NP_650190.1	Sacchrp_dh_NADP	9..139	CDD:281434	105/129 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461649
Domainoid	1	1.000	125	1.000	Domainoid score	I1791
eggNOG	1	0.900	-	-		E1_COG3268
Homologene	1	1.000	-	-		H9334
Inparanoid	1	1.050	222	1.000	Inparanoid score	I1197
Isobase	1	0.950	-	0	Normalized mean entropy	S4069
OMA	1	1.010	-	-		QHG56565
OrthoDB	1	1.010	-	-		D302978at33208
OrthoFinder	1	1.000	-	-		FOG0002586
OrthoInspector	1	1.000	-	-		mtm6482
orthoMCL	1	0.900	-	-		OOG6_101495
Panther	1	1.100	-	-	P	PTHR12286
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4081
SonicParanoid	1	1.000	-	-		X1697
	15	14.790