DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sccpdh1 and ldp-1

DIOPT Version :9

Sequence 1:	NP_649517.1	Gene:	Sccpdh1 / 40623	FlyBaseID:	FBgn0037298	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001379806.1	Gene:	ldp-1 / 178692	WormBaseID:	WBGene00017719	Length:	426	Species:	Caenorhabditis elegans

Alignment Length:	432	Identity:	169/432 - (39%)
Similarity:	254/432 - (58%)	Gaps:	24/432 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RLDVIIFGASGFTGKYTVFEAVT--VLRGLRWGIAGRNREKLEAVLKEMGAKAKKDLSQVPIFIA 67
            |.||:::|||||||.|.|...|.  ...||.:.:|||:.:||..||:.:..|..||:|...:.:|
Worm     3 RYDVVVYGASGFTGAYVVEYLVNSEQFEGLSFAVAGRSEKKLREVLRNISQKTGKDVSNAAVIVA 67

  Fly    68 DVNDQASLLEMAKKCRIVVNTAGPYRFHGENVVKCCIESGTHHVDVSGEPQYMETMQLRYDQLAR 132
            |..|:.||.|||::..:|:|..||||.:||.|||..:|:|..|||:||||.::|.||.:|.:.|:
Worm    68 DSADERSLNEMARQANVVINAVGPYRLYGEAVVKAAVENGASHVDISGEPAWIEKMQQKYSKQAK 132

  Fly   133 EKGVYVVSACGFDSIPADMGVVFVEKNFDGVVNSVETFLETGIKEGGSGGGTAGLNYGTWESAVY 197
            |:|||||||||:||||||:||.|::|||.|.:|.||:|::  :..|.||   ...|.||:::.:.
Worm   133 EQGVYVVSACGWDSIPADLGVNFLKKNFHGDLNHVESFVQ--LLTGPSG---YSFNAGTYQTLIL 192

  Fly   198 GL--AHSDELRGIRKQIYPQRLPRFYPFLKPRPLVF--RSTEVDKVCLPFPGSDRSVVMRSQRFL 258
            ||  |.:|:|..:||:|.|:::.|....|..||.::  :..|::.|.:||||:|:|::.|||.:.
Worm   193 GLSGAATDKLGAVRKEIMPEKIVRGAVKLPKRPTLWEIKEKELNGVAVPFPGADKSIINRSQYYD 257

  Fly   259 YDQDKKRPVQMQAYVGFSS----WLVAGGVIFFATIFGLLSKFKLGRTLLLNYPGLFSGGLASRS 319
            ....:.||:.|:.|:..||    :|: |..|.|.:||   .|:...|.:|..||...|..:...|
Worm   258 ATSRQVRPIHMETYIRLSSQFYGYLI-GLWIMFLSIF---VKYPFTRRILQQYPDQCSFYMFKNS 318

  Fly   320 GPSEESMERTYFKMTFKASGWLKSDRLAESSNQYTESPTKTLMVRVSGMNPGYGATCVAVLSAAL 384
            |||...|....|...|...|:.::..|   ..|:.....:.::....|.:.||.||...||||||
Worm   319 GPSARQMAEASFVYWFFGYGYKETLPL---DQQHEGKINRKVLATCKGPDAGYIATSGCVLSAAL 380

  Fly   385 TILRESDKMPSTGGVLPPAAAFSKTGLISELEKHDHGIKFEI 426
            |::|:.|.:|..|||...||||..:.:...|.  ..||.:::
Worm   381 TLIRDKDNLPKDGGVYTTAAAFGNSKIYDYLA--SFGITYQL 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sccpdh1	NP_649517.1	COG3268	7..426	CDD:225807	168/428 (39%)
Sccpdh1	NP_649517.1	Sacchrp_dh_NADP	8..139	CDD:281434	61/132 (46%)
ldp-1	NP_001379806.1	COG3268	4..421	CDD:225807	168/431 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163998
Domainoid	1	1.000	153	1.000	Domainoid score	I2624
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9334
Inparanoid	1	1.050	285	1.000	Inparanoid score	I1724
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56565
OrthoDB	1	1.010	-	-		D302978at33208
OrthoFinder	1	1.000	-	-		FOG0002586
OrthoInspector	1	1.000	-	-		mtm4769
orthoMCL	1	0.900	-	-		OOG6_101495
Panther	1	1.100	-	-	LDO	PTHR12286
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4081
SonicParanoid	1	1.000	-	-		X1697
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940