DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cno and SEC3

DIOPT Version :9

Sequence 1:	NP_001303494.1	Gene:	cno / 40620	FlyBaseID:	FBgn0259212	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	NP_010924.1	Gene:	SEC3 / 856726	SGDID:	S000000810	Length:	1336	Species:	Saccharomyces cerevisiae

Alignment Length:	1257	Identity:	224/1257 - (17%)
Similarity:	415/1257 - (33%)	Gaps:	398/1257 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 TKCIRVASDATVTDVIDTLIEKFRPDMRMLSVPNYA----LYEVH-----------ANGEERRLN 105
            |:..|.:...:|..|......::...|:.|:...|:    |.||:           ...|.|||.
Yeast   282 TERTRRSETESVNPVSTPASVEYHAGMKSLNKAPYSSNSTLNEVNKRYELEQQQQQEEAELRRLE 346

  Fly   106 ADEKPLLVQLNWHIDDREGRFLLKNIDQKTTPIEQTDLNFKRKLSKREKKEQKKKE--KMAKLSS 168
             ::|.|.:|....:...|....:|..::|    .|.:|..:|:|.:.|:|.|.:.|  |..:|..
Yeast   347 -EQKRLQLQKENEMKRLEEERRIKQEERK----RQMELEHQRQLEEEERKRQMELEAKKQMELKR 406

  Fly   169 DPPTSNGSHLGLGNGVGASSGSAHMNGNAGGTGGDSSDAVAGKLYTELPETSFTRSISNPEAVMR 233
            .........|                                |...||.|....:........::
Yeast   407 QRQFEEEQRL--------------------------------KKERELLEIQRKQREQETAERLK 439

  Fly   234 RRRQQKLEKKLQQFRSRDGGPDTGGTLKIYGESLCQDVPYKTLLLSIRDCAQAVVREMLTKYGLE 298
            :..|:.|.||.::.:|:..        |:..||..|::.                         .
Yeast   440 KEEQEALAKKEEEEKSKRN--------KVDNESYTQEIN-------------------------G 471

  Fly   299 KADPLHYCLVQVNSDGTEYILDDDECPLSILMNHPTSRGSIMFHVRRRPADSQPRRRKKKPLGAA 363
            |.|.|...|..|.::.||              ..||.:...  :|..| :.::...:.||||..|
Yeast   472 KVDNLLEDLNAVLAEETE--------------TTPTMQNGT--YVPER-STARAHDQLKKPLNIA 519

  Fly   364 NGANHISGDREGPVLVEVTHSGDGGRRIKLGSDPVEVGSANTNCLQLFGPSIQPRHCLISLLEGV 428
            .              ||.....|....|.| ||  |:...||:  .|.|.....::.| |..:|
Yeast   520 K--------------VESLGGSDLNDSISL-SD--EIAGLNTS--NLSGEDQDEKNDL-SFEKG- 563

  Fly   429 CTVTPLHTDALTFVNGHHISQPTILHNGSVVMFGRVASYRFLDSPTDGRYNLALSQSQ------- 486
                    |.:.:.|......|.:.|..|::.....|..:.|..|.:...:.||.:|:
Yeast   564 --------DEVRYSNNFEGEAPHVYHEVSIIQEEAPAVSQKLILPEENNESEALIESKEEIKTME 620

  Fly   487 -LDSACLYESRSPTSPGSWNDEDGALSSTHKSD---------YDHH----QQANHSSAYHNNNNN 537
             :|...|.|..:..   :|:.||.|.|...:.|         ::.:    |:...:...:.:..|
Yeast   621 NIDDEVLLEILTDI---NWSIEDDADSMIERIDLRLAETEYLFNQNLLSLQKIGPNIRPYEDKVN 682

  Fly   538 SSDHPLSSTL----------RDVVDSKAGQDQG--ANSGN----------------YDGQSL--- 571
            ...|.:..||          .:.:::...||.|  ..|.|                .|..||
Yeast   683 DECHRIIPTLSLFLMEMSNFSNDIENVESQDNGLQVESANKKLLWNTLDELLKTVSLDEISLNQL 747

  Fly   572 ------EGNL---ENE----TKSISSLKSGGSNSQDRSPKMTGSGILAGGGSGSGDTQGQEPILP 623
                  |.||   ||:    .|:..::.|.|:..:....:::|                    |.
Yeast   748 LECPIREKNLPWMENQLNLLLKAFQAIGSDGNEVEYNLREISG--------------------LK 792

  Fly   624 AVLEFPETHQELFLRHIISELD--------VNVPHFKLAPVYSLYLCARYRASTHYRPELQPTER 680
            ..|:|.|...::||..|:.|:.        .::.|.::..:.:..|.        :.|
Yeast   793 QRLQFYEKVTKIFLNRIVEEMQKKFSNIRGQDISHDQMIRILTTLLI--------FSP------- 842

  Fly   681 AHKLTMFLHHVANLVYSVVQEQYT---DPRILAFWMANSSEFLHFLKSDRHISAFSV-------- 734
               |.:|...::...|..:.|.:.   .|..:..|....|:......:|..::..|:
Yeast   843 ---LILFCKEISQKSYQAIVENWNVSIQPVYMELWTKKISQLQGIDTNDEKMNELSLSQLLNEWD 904

  Fly   735 ----------------QAQEVLAEAVQT------AFRNLVNC-FRLELSQTLNQFLSENIDHDSA 776
                            .:..:|.|.:||      .::|.|.. |.:.......:::....|.|:.
Yeast   905 TFRKERKTNDINPVFKNSFSLLTECLQTMRQECIVYQNFVEVFFHISSKHNFEEYIKHFNDPDAP 969

  Fly   777 AGLVLTVLGSAMALLRRCRVNAALTIQLFSQLF---------HYINVICFNTIVANSQMCTGDWG 832
            ..|:.||     .:::..|..|.:..||.|::|         :::.::.....||.:
Yeast   970 PILLDTV-----KVMQSDREAAVIETQLVSRIFQPIVTRLSSYFVELVKAEPTVAPA-------- 1021

  Fly   833 KVMTERLQLLELWAERQGLELAADCH---LAKINQC-AQFLQAPKSSVEEIQQLACSCFRLNSLQ 893
                     |..:.|.:...|.:..|   |:.:.:. .|..|....:||| |.|...  |:::
Yeast  1022 ---------LTFYLENEIKSLESSNHEFLLSAVTRMYTQIKQVWSDNVEE-QVLHFE--RISN-- 1072

  Fly   894 MAALLQQEKLPRNLVDTAIRMAESVADELTRADGREVRLEESPELHLALLLPDDGF---SCDVVR 955
              |....|.|| .::|..:.:..|  ::|.:...|.:.::::.|.:.::.|.:..|   |....|
Yeast  1073 --ATTNGEILP-GILDLPVGLKNS--EDLFQFAKRSMDIKDTDEGYESIELMNSSFRKLSIAATR 1132

  Fly   956 GIPTGLVD-FLNPLQQQGMCRLAAQPTSIGLWTVYMHQFNARSSSAMSNKLPQPELQLIKLHKNS 1019
            .|....|: .:||                          |...::|::|..    ::.|.|..||
Yeast  1133 SITHKEVNSSINP--------------------------NLSDTAALNNDY----METISLLVNS 1167

  Fly  1020 NGMG--LSIVAAKGAGQEKLGIYIKSVVPGGAADADGRLQAGDQLLRVDGQSLIGITQERAADYL 1082
            |.:.  ||::     ...|.||:            |..||        :.:.:..:.:|..|.:|
Yeast  1168 NWLTEMLSML-----NFNKDGIF------------DTSLQ--------NVKKVFDVEKESYASFL 1207

  Fly  1083 VR-TGPVVSLEVAKQGAIYHGLATLLQQPSPVIQRGNRR---MSERDLTRMGGAESTKSLGPLIA 1143
            :| |.|       |..|..:|::.:::..:.|......|   .|.::|..:..|.::..:..|:.
Yeast  1208 LRDTMP-------KLTAFVYGVSNIIENTNNVNMTNPSRWAAYSRQNLENILLAYTSHEIETLVK 1265

  Fly  1144 NNHPNHSLSLSQHLNNSHNNTL 1165
            ..|.:.......|..|:.||.|
Yeast  1266 RLHTHMVNDFGYHQENAINNVL 1287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cno	NP_001303494.1	AF6_RA_repeat1	20..131	CDD:176377	19/89 (21%)
		AF6_RA_repeat2	257..346	CDD:176376	14/88 (16%)
		FHA	398..461	CDD:278899	13/62 (21%)
		Myo5p-like_CBD_afadin	631..941	CDD:271255	58/364 (16%)
		DegQ	<983..1112	CDD:223343	25/131 (19%)
		PDZ	1009..1097	CDD:214570	20/90 (22%)
SEC3	NP_010924.1	PH_Sec3	82..232	CDD:270125
		PTZ00121	<283..478	CDD:173412	46/264 (17%)
		SMC_N	<348..629	CDD:308206	74/395 (19%)
		ARGLU	<358..444	CDD:405931	18/121 (15%)
		Sec3_C	640..1316	CDD:418729	133/780 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2286
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030