DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cno and afdna

DIOPT Version :9

Sequence 1:	NP_001303494.1	Gene:	cno / 40620	FlyBaseID:	FBgn0259212	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	XP_021324351.1	Gene:	afdna / 558359	ZFINID:	ZDB-GENE-050419-52	Length:	1931	Species:	Danio rerio

Alignment Length:	2241	Identity:	741/2241 - (33%)
Similarity:	1060/2241 - (47%)	Gaps:	525/2241 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DREAVRSVIQQWNANRLDLFALSEPDENLLFHGVMRFYFQD--AGQKVATKCIRVASDATVTDVI 71
            :|..:..:|..|||||||||.:|:|.|:|.|||||||||||  || ..|||||||:|.||..|||
Zfish     8 ERRKLADIINHWNANRLDLFEISQPTEDLEFHGVMRFYFQDRVAG-NFATKCIRVSSTATTQDVI 71

  Fly    72 DTLIEKFRPDMRMLSVPNYALYEVHANGEERRLNADEKPLLVQLNWHIDDREGRFLLKN---IDQ 133
            :||.|||||||||||.|.|:|||||.:||||:|:.|||||:|||||:.|||||||:|||   |..
Zfish    72 ETLAEKFRPDMRMLSSPKYSLYEVHVSGEERKLDLDEKPLVVQLNWNKDDREGRFVLKNENDIMP 136

  Fly   134 KTT----PIEQTD---LNFKRKLSKREKKEQKKKEKMAKLSSDPPTSNGSHLGLGNGVGASSGSA 191
            |.|    |.::.:   .||||.|||:|||::||:||.| .|..|                 .|..
Zfish   137 KRTLTNGPEKEKEGVIQNFKRTLSKKEKKKEKKREKEA-FSRIP-----------------DGDD 183

  Fly   192 HMNGNAGGTGGDSSDAVAGKLYTELPETSFTRSISNPEAVMRRRRQQKLEKKLQQFRSRDGGPDT 256
            |:.....|    .:..:|.::|.::|||||||:|||||.||:|||||||||::|:|||.||.||:
Zfish   184 HVLNREDG----ENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSEDGRPDS 244

  Fly   257 GGTLKIYGESLCQDVPYKTLLLSIRDCAQAVVREMLTKYGLEKADPLHYCLVQV---NSDGT-EY 317
            ||||:||.:||..::||||:|||..|.|...|.|.|.||||||.:|..||:.||   |.... |.
Zfish   245 GGTLRIYADSLKPNIPYKTILLSTTDMADFAVAEALEKYGLEKENPRDYCIAQVIHANDKAVKET 309

  Fly   318 ILDDDECPLSILMNHPTSRGSIMFHVRRRPADSQPRRRKK--KPLGAANGA-------------- 366
            ||||.:|||.||.:..:.:.:::|.:::||.|..||:.:|  ..:|..:|:
Zfish   310 ILDDTDCPLQILRDWTSDKEALVFQLKKRPPDYAPRKGRKPDNRMGPQHGSIPPEKLPYLVELSP 374

  Fly   367 -----------NHISG--DREGPVLVEVTHSGDGGRRIKLGSDPVEVGSANTNCLQLFGPSIQPR 418
                       :|..|  .|:.|.|..:.||     ..::|||..|.|:     :|||||.|.|.
Zfish   375 GRGSHYAYYYRHHEDGSDSRDKPKLYRLQHS-----VTEVGSDRSEDGN-----IQLFGPGILPH 429

  Fly   419 HCLISLLEGVCTVTPLHTDALTFVNGHHISQPTILHNGSVVMFGRVASYRFLDSPTDGRYNLALS 483
            ||.:...:|:.|:||.:.||.|||:|..|:..|:|.:|..|.||....::|:|...|
Zfish   430 HCDLMHADGLVTITPANMDAETFVDGQRIADTTVLRSGVTVQFGATHVFKFVDPSYD-------- 486

  Fly   484 QSQLDSACLYESRSPTSPGSWNDEDGALSSTHKS------DYDHHQQANHSSAYHNNNNNSSDHP 542
                      :|.|...||.      .:...|||      .:|.|...:..||.          |
Zfish   487 ----------QSMSKRDPGP------MMKGRHKSGSVPETTFDLHGDIHSGSAL----------P 525

  Fly   543 LSSTLRDVVDSKAGQDQGANSGNYDGQSL-EGNLENETKSISSLKSGGSNSQDRSPKMTGSGILA 606
            .|.:        :|:.:...|||...:.| :..:..|.:..|  |..| .|||
Zfish   526 TSKS--------SGKLEMERSGNSSERGLVKPMIRGEQQDFS--KHDG-RSQD------------ 567

  Fly   607 GGGSGSGDTQGQEPILPAVLEFPETHQELFLRHIISELDVNVPHFKLAPVYSLYLCARYRASTHY 671
                      |.|..|||.:||.|..::.||..||:..:.:..||||:|.|.||:..||..|:.|
Zfish   568 ----------GPELTLPASIEFRENSEDAFLSAIINYTNSSTVHFKLSPTYVLYMTCRYVMSSQY 622

  Fly   672 RPELQPTERAHKLTMFLHHVANLVYSVVQE-------QYTDPRILAFWMANSSEFLHFLKSDRHI 729
            ||::.|:||.||:...::.:.:::..|:||       |......|||||||:||.|:|:|.|:.:
Zfish   623 RPDISPSERTHKVIAIVNKMVSMMEGVIQEIAEGDQKQKNIAGALAFWMANASELLNFIKQDKDL 687

  Fly   730 SAFSVQAQEVLAEAVQTAFRNLVNCFRLELSQTLNQFLSENIDHDSAAGL---VLTVLGSAMALL 791
            |..::.||:|||..||.||:.||:|.:.:|:..:..||.:..:.:.....   ||..|..||:||
Zfish   688 SRITLDAQDVLAHLVQMAFKYLVHCLQSDLNNYMPAFLEDPDEQNPQRPKIEDVLHTLTGAMSLL 752

  Fly   792 RRCRVNAALTIQLFSQLFHYINVICFNTIV--ANSQMCTGDWGKVMTERLQLLELWAERQGLELA 854
            |||||||||||||||||||::|:..||.:|  |:|.:|:..||.::.::|..:|.|||:||||||
Zfish   753 RRCRVNAALTIQLFSQLFHFVNMWLFNKLVTEADSGLCSHYWGAILRQQLSHIEAWAEKQGLELA 817

  Fly   855 ADCHLAKINQCAQFLQAPKSSVEEIQQLACSCFRLNSLQMAALL-------QQEKLPRNLVDTAI 912
            |||||::|.|....|...|.|::::|.:..:||:|||||:.|||       .:..:|..|:|..:
Zfish   818 ADCHLSRIVQATTLLTMDKYSMQDVQNINNTCFKLNSLQLNALLSNYHCAPDEPYIPPELIDHVV 882

  Fly   913 RMAESVADELTRADGREVRLEESPELHLALLLPDDGFSCDVVRGIPTGLVDFLNPLQQQGMCRLA 977
            .:||:.||||.|:|||||:|||.|:|.|..|||:||:||||||.||.|..:||.||.|:|.|||.
Zfish   883 AVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGFQEFLEPLCQRGFCRLT 947

  Fly   978 AQPTSIGLWTVYMHQFNARSS-SAMSNKLP---QPELQLIKLHKNSNGMGLSIVAAKGAGQEKLG 1038
            ..|.|.|.||:|....|..|. ||.:::||   :||:..:.|.|: |||||||||||||||:|||
Zfish   948 PHPRSPGTWTIYFEGANCDSHFSADTSELPMRKEPEIVTVTLKKH-NGMGLSIVAAKGAGQDKLG 1011

  Fly  1039 IYIKSVVPGGAADADGRLQAGDQLLRVDGQSLIGITQERAADYLVRTGPVVSLEVAKQGAIYHGL 1103
            |||||||.|||||.||||.||||||.|||:||:|::|||||:.:.|||.||:|||||||||||||
Zfish  1012 IYIKSVVKGGAADMDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTGSVVTLEVAKQGAIYHGL 1076

  Fly  1104 ATLLQQPSPVIQRGNRRMSERDLTRMGGAESTKSLGPLIANNHPNHSLSLSQHLNNSHNNTLGNS 1168
            ||||.||||::.|.:.|          |......|.|      .:....|       :||::.|.
Zfish  1077 ATLLNQPSPMMPRASDR----------GRGDKGKLRP------KSEGFEL-------YNNSVQNG 1118

  Fly  1169 NNSSIINPLAAHLPNSKSVPALHHHTGSGTISLANSKSRSTHSLHNNTSGMGGIGGAAAGG---M 1230
            :..|.......: |..|....|             .|:|:.|....|.:..    ..:.||   .
Zfish  1119 SPESPQGTWDTY-PEPKKEDRL-------------LKNRADHRSSPNVANQ----AQSPGGKPVY 1165

  Fly  1231 LGQPNGSQNNANGNGNGNEQGFYQNLSVYRAQNQSQPILNERPPIAAHAAMNAYNGSSPLAPQQQ 1295
            .|.|....:.:.||...:|:........|....|:.|        ..:....|......:.|.|.
Zfish  1166 PGAPGKITSVSTGNLCPDEEPSPPRPEAYPIPTQTYP--------REYFTFPASKSQDRMGPGQP 1222

  Fly  1296 PQQQQQSPYQQQQQQQHMQANANLPPTRPVSAYYHSQQSAQQQLQQQQQQQ--------QQHSLQ 1352
            .|..:|.|               |||..     .||..|...|...:.|::        ....|:
Zfish  1223 WQNNEQEP---------------LPPMD-----NHSNNSMVMQRVARSQEELCDMPGGYPGERLR 1267

  Fly  1353 QQQFALSSGNLNGQQQQQQQHQ--------HQHQLTLNNRTKSQQ--NFQHTL------------ 1395
            |:...|    |..|||::.::|        ||...::.:.|.||:  ||..:.
Zfish  1268 QEDLML----LQQQQQREAEYQRGVGEHWNHQVSSSVESSTSSQEHLNFSSSSGSRTQGNHKSGP 1328

  Fly  1396 -RMQQMMAP-----SMPNISNM--------YHHQQQQQQQLPL---QQQQQQQQQPLMSSSQSMQ 1443
             |.:..:||     |.|:.|::        .|:..:.|..|||   ....|||||....
Zfish  1329 GRWKTPLAPHSGPVSQPSRSDLPPPPPPPPAHYDFEPQTDLPLPPPPSATQQQQQAAAD------ 1387

  Fly  1444 NVNDFAGGYQNGSLEYRRSQLHDPSTLYEIQQQQLQQQQQQQQQQQQQQQASPNFIALPPKPLGS 1508
                             |.:..|....||.::.:|:::::::::.|:::...    ...|...|.
Zfish  1388 -----------------RKKREDQQRWYEKEKARLEEERERKRRDQERKLVQ----IRNPSVSGP 1431

  Fly  1509 LQS-------PNKPNVPPSTAPK----PQQDKPPLPPTATHPLFKATQQIAPGMNYVASTLDPPK 1562
            :..       |..|.:||.|.|:    |.|..||..|.....|....:|  |..:.|...|.|.:
Zfish  1432 VMHNNQHGPVPPSPQMPPMTLPQSYLPPVQQPPPPQPARPDKLSSLPRQ--PPQDTVIRDLLPQQ 1494

  Fly  1563 G---------SYVASNQGNNRPLHSGS-NPWEREEREKDLEMRREHIRQWREQQISELSQIVSRS 1617
            .         .|:..::.......|.| :||:|:.|||..:.::.||....:::|.||.....|:
Zfish  1495 QPRTIERRDLQYITISKEELSASDSLSPDPWKRDAREKLEKQQQLHIVDLLDKEIQELQAKPERT 1559

  Fly  1618 PMQEEQLKTLILERDFERRAQELQEQEEQDQEQQYDKENVQE---LFRLAGGGQVSAIQTPITSY 1679
            ....::|:.|:||..|::|.||.::.||.::|:  |.|:|..   :.||....:.
Zfish  1560 AEDNDRLRKLMLEWQFQKRLQESKQNEEDEEEE--DDEDVDTTLIMQRLEAEKRA---------- 1612

  Fly  1680 RQTEIKLAEMPDSNSLVDSVPPQPPAPTAQPLSSNTQQPKSILKHNRYSEGGVGPSGAPSSPSK- 1743
            |||.:                  |.......|....::.|..|:..|..|   ....|.....:
Zfish  1613 RQTAV------------------PAISVLDLLQDEERRRKQQLEEIRKRE---AEERAKQEEERR 1656

  Fly  1744 ---SQKSASFADERHLHTEHPISNLAKEL--------NQLTMLDKDN------------------ 1779
               .:::...|||:....|...:.|..|.        .:|...|:..
Zfish  1657 WREEERARREADEKRRQEEEYYTRLEAERRRQHEEAERKLPTPDETGLYRPPLPRDYQPPSPSSA 1721

  Fly  1780 --NNETLDAVVPPPPPPERNSSYLIMSQQKLRGSTGNATSSMGLLKTATSNQAAAAVEIKKASLL 1842
              .|.|..|   |||||:||:||                     |||    |.|:...|..|..:
Zfish  1722 PATNHTTSA---PPPPPQRNTSY---------------------LKT----QVASPDTIYTAKFV 1758

  Fly  1843 N------TQTNNNNNLSGSLNNNTMHGSPLSAMELNAAYVSATGTGIIGGL-GTPPPPPPLMQRD 1900
            :      .:...:..|:|.:.                  :|||... .|.| ..|.|.||...|.
Zfish  1759 SYNDEEEEEDEEDAGLTGQVK------------------LSATRKS-YGDLPPAPKPQPPPTARK 1804

  Fly  1901 NKRVSFHDEENNFVSGNSQQQQLQQQYIMDNYGMEHQDLDTIREDTSYLQHNLDASML------P 1959
            .:.||    :..|:|.:.|                             |...|:|:..      |
Zfish  1805 PRPVS----DGIFLSNSFQ-----------------------------LPAGLNANSTALKTGQP 1836

  Fly  1960 SMPATPDAAL-------WNTSVQSTPGVIGAQEVYRDPRTRRLAEKQQQQQQQRAGDAVPEKLSF 2017
            .:|.|..:.:       :|:...:|.|::.. |||:|||.:  ..|....|:...|.| ||.|:|
Zfish  1837 PLPFTKPSFIPSANSKGFNSYTGNTTGLVSG-EVYKDPRDK--WTKGSPDQENTIGGA-PENLTF 1897

  Fly  2018 KEKMKMFALESGEDKTPKDKLKISRAQRDID 2048
            ||:.::|:    :.|...:|:|.||...:::
Zfish  1898 KERQRLFS----QGKEVSNKVKASRKLMELE 1924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cno	NP_001303494.1	AF6_RA_repeat1	20..131	CDD:176377	84/115 (73%)
		AF6_RA_repeat2	257..346	CDD:176376	43/92 (47%)
		FHA	398..461	CDD:278899	26/62 (42%)
		Myo5p-like_CBD_afadin	631..941	CDD:271255	143/328 (44%)
		DegQ	<983..1112	CDD:223343	89/132 (67%)
		PDZ	1009..1097	CDD:214570	64/87 (74%)
afdna	XP_021324351.1	AF6_RA_repeat1	19..131	CDD:176377	83/112 (74%)
		UBQ	245..338	CDD:320785	43/92 (47%)
		FHA	413..472	CDD:306897	26/63 (41%)
		Myo5p-like_CBD_afadin	582..911	CDD:271255	143/328 (44%)
		PDZ_signaling	984..1067	CDD:238492	60/83 (72%)
		DUF4670	<1526..1696	CDD:330369	42/202 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595008
Domainoid	1	1.000	155	1.000	Domainoid score	I4192
eggNOG	1	0.900	-	-		E1_KOG1892
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	965	1.000	Inparanoid score	I308
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006109
OrthoInspector	1	1.000	-	-		oto40942
orthoMCL	1	0.900	-	-		OOG6_105992
Panther	1	1.100	-	-	LDO	PTHR10398
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2286
SonicParanoid	1	1.000	-	-		X5048
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.780