DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cno and RADIL

DIOPT Version :9

Sequence 1:	NP_001303494.1	Gene:	cno / 40620	FlyBaseID:	FBgn0259212	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	NP_060529.4	Gene:	RADIL / 55698	HGNCID:	22226	Length:	1075	Species:	Homo sapiens

Alignment Length:	1169	Identity:	231/1169 - (19%)
Similarity:	387/1169 - (33%)	Gaps:	409/1169 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 TRSISNPEAVMRRRRQQKLEKKL------QQFRSRD------GGPD----------TGGTLKIYG 264
            |..|.:|....:.:||.:|...:      .::|..|      |..|          ..|.||::|
Human     5 THFIMSPPTKSKLKRQSQLLSSMLSRTLSYKYRDLDSTFSSLGASDDPAELSTQLSAPGVLKVFG 69

  Fly   265 ESLCQDVPYKTLLLSIRDCAQAVVREMLTKYGLEKADPLHYCLVQVNSDGTEYILDDDECPLSIL 329
            :|:|....||::|.:....|:.:|:|.|.:|.|   ||         ....:|:|.|
Human    70 DSVCTGTHYKSVLATGTSSARELVKEALERYAL---DP---------RQAGQYVLCD-------- 114

  Fly   330 MNHPTSRGSIMFHVRRRPADSQPRRRKKKPLGAANGANHISGDREGPVLV-EVTHSGDG-GRRIK 392
                         |..:..|:..|.:.:        ...:.||.|.|:|: |:....:| .||.:
Human   115 -------------VVGQAGDAGQRWQAR--------CFRVFGDSEKPLLIQELWKPREGLSRRFE 158

  Fly   393 L--GSDPVEVGSANTNCLQLFGPSIQPRHCLISLLEGVCTVTPLHTDALTFVNGHHISQPTILHN 455
            |  .||..|:.:...:.:.. |.:.|.|....|..:|  |.||...||.:
Human   159 LRKRSDVEELAAKEVDTITA-GINAQARRLQRSRAKG--TPTPALGDARS--------------- 205

  Fly   456 GSVVMFGRVASYRFLDSPTDGRYNLALSQSQLD--SACLYESRSPTSPGSWNDEDGALSSTHKSD 518
                            ||.. |....:|::.|.  :|....::.|..||    .|....|.::|.
Human   206 ----------------SPPP-RLRRTVSETSLSPVNALPAAAQGPEEPG----PDAMRYSLYQSP 249

  Fly   519 Y----DHHQQANHSSAYHNNNNN--------SSDHPLSSTLRDV------VDSKAGQDQGANSGN 565
            :    ..:.|.:.|..|..|.:.        ||...:|.:..|:      :..:...|.|..:|.
Human   250 HLLLLQGYSQQHDSLVYVLNRDRHTVGQRTPSSKPSISLSAPDILPLHCTIRRQPLPDSGQAAGR 314

  Fly   566 -----YDGQSLEGNLENETKSISSLKSGG----------------------SNSQDRSPKMTGSG 603
                 ..|..:..|..........|..|.                      :.:..|...:..|.
Human   315 LVLEPIPGAHISVNFSEVGHRTVVLHHGDLLSLGLYYLLLFKDPAQAQPLPARALARLRAVPQSC 379

  Fly   604 ILAGGGSGS-GDTQGQEPILP----AVLEFPETHQELFLRHIISELDVNVPHFKLAPVYSLYLCA 663
            .|.|...|: |.....:..||    .:|||....::..|:.|::.::......||.|.:.|.||.
Human   380 RLCGAALGARGAASPTQAALPRRQQLLLEFEPHLEDTLLQRIMTLIEPGGDDHKLTPAFLLCLCI 444

  Fly   664 RYRASTHYRPELQPTERAHKLTMFLHHVANLVYSVV----------QEQYTDPRILA-------- 710
            ::.| ||::|        ......|..:|.|:...|          |.|..:|..||
Human   445 QHSA-THFQP--------GTFGQLLLKIARLIRETVWEKTKELAEKQAQLQEPISLASCAMADLV 500

  Fly   711 -------FWMANSSEFLHFLKSDRHI----------------SAFSV------QAQEVLAEAVQT 746
                   |||:||.|.|:|::....:                |.||.      :|..||.|.|..
Human   501 PDLQPILFWMSNSIELLYFIQQKCPLYMQSMEEQLDITGSKESLFSCTLTASEEAMAVLEEVVLY 565

  Fly   747 AFRN---------------LVNC--FRLELSQTLNQF--LSENIDHDSAAGLVLTVLGSAMALLR 792
            ||:.               |:.|  |:.|..::.:..  |.|.:..      |::|..:|:.|||
Human   566 AFQQCVYYVSKSLYICLPALLECPPFQTERRESWSSAPELPEELRR------VVSVYQAALDLLR 624

  Fly   793 RCRVNAALTIQLFSQLFHYINVICFNTIV--ANSQMCTGDW--GKVMTERLQLLELWAERQGLEL 853
            :.:|:..:..|:.:.||.:...:..|.::  ..|..|. .|  |.....|||.|..|....|...
Human   625 QLQVHPEVASQMLAYLFFFSGTLLLNQLLDRGPSLSCF-HWPRGVQACARLQQLLEWMRSAGFGA 688

  Fly   854 AADCHLAKINQCAQFLQAPKSSVEEIQQLACSCFR-----LNSLQMAALLQQEKLPRNLVDTAIR 913
            |.:....|::.....|..|::   ::.|::.:..|     |:..|:..||           |..:
Human   689 AGEHFFQKLSCTLNLLATPRA---QLIQMSWTALRAAFPALSPAQLHRLL-----------THYQ 739

  Fly   914 MAESVADELTRADGREVRLEESPELHLA------------LLLPDDGFSCDV------------- 953
            :|.::....|...|    .::|||...:            ::||.|||..|:
Human   740 LASAMGPMSTWEPG----AQDSPEAFRSEDVLESYENPPPIVLPSDGFQVDLEANCLDDSIYQHL 800

  Fly   954 --VRGIPTGLVDFLN-------------PLQQQGM------------------------------ 973
              ||....||....:             |:..:||
Human   801 LYVRHFLWGLRSRASPGSPGRPGSGASQPVCPEGMHHVVLDGHLEAPSCPLAPRDPGPAAREVAP 865

  Fly   974 -----------------------------------CRLAAQPTSIGL------W---------TV 988
                                               |.|....|.:|.      |         .:
Human   866 ERTLPLRGAPWAQAPPGRQPSRGGSQAGPPHTDSSCLLTPPSTPLGPEPGDPDWPESGGPCGKAL 930

  Fly   989 YMHQFNARS----------SSAMSNKL-PQPELQ-----------LIKLHKNSNGMGLSIVAAKG 1031
            ...|.|..|          |:|::.:. |.|..:           .::|.:..:|:|:.::....
Human   931 PERQRNGLSGLRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMH 995

  Fly  1032 AGQEKLGIYIKSVVPGGAADADGRLQAGDQLLRVDGQSLIGITQERAADYLVRTGPVVSLEVAK 1095
            ......|:||::::||..|.|||||..||::|.|:|.||:|:...||.|.:...|..:...|||
Human   996 THLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cno	NP_001303494.1	AF6_RA_repeat1	20..131	CDD:176377
		AF6_RA_repeat2	257..346	CDD:176376	21/88 (24%)
		FHA	398..461	CDD:278899	11/62 (18%)
		Myo5p-like_CBD_afadin	631..941	CDD:271255	83/384 (22%)
		DegQ	<983..1112	CDD:223343	38/150 (25%)
		PDZ	1009..1097	CDD:214570	29/98 (30%)
RADIL	NP_060529.4	RA	61..164	CDD:279168	33/143 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..237		16/87 (18%)
		FHA	273..343	CDD:278899	10/69 (14%)
		Myo5p-like_CBD_Rasip1	414..779	CDD:271256	83/398 (21%)
		DUF4764	<809..935	CDD:292583	10/125 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	872..967		12/94 (13%)
		PDZ_signaling	974..1058	CDD:238492	26/83 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910