Protein Alignment cno and RASIP1

DIOPT Version :9

• Sequence 1: NP_001303494.1
• Gene: cno / 40620
• FlyBaseID: FBgn0259212
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: NP_060275.2
• Gene: RASIP1 / 54922
• HGNCID: 24716
• Length: 963
• Species: Homo sapiens
• Alignment Length: 1062
• Identity: 199/1062 - (18%)
• Similarity: 311/1062 - (29%)
• Gaps: 387/1062 - (36%)

  Fly    18 QQWNANRL--DLFALSEPDENLLFH-----GVMRFYFQDAGQKVATKCIRVASDATVTDVIDTLI 75
            |:|.:.:.  :|.|...|:..|...     ||::.:..........|.:...:.:|..:::...:
Human   116 QRWASEKKLPELAAGVAPEPPLATRATAPPGVLKIFGAGLASGANYKSVLATARSTARELVAEAL 180

  Fly    76 EKF--------RPDMRMLSVPNYALYEV--------HANGEERR-----LNADEKPLLVQLNWHI 119
            |::        .|. ....|..:||.:.        ..:||.|.     |...|:|||||..|..
Human   181 ERYGLAGSPGGGPG-ESSCVDAFALCDALGRPAAAGVGSGEWRAEHLRVLGDSERPLLVQELWRA 244

  Fly   120 DDREGRFLLKNIDQKTTPIEQTDLNFKRKLSKREKKEQKKKEKMAKLSSDP---------PTSNG 175
              |.|                    :.|:...|.::|.::.|:.|..::|.         |..|.
Human   245 --RPG--------------------WARRFELRGREEARRLEQEAFGAADSEGTGAPSWRPQKNR 287

  Fly   176 SHLGLGNGVGASSGSAHMNGNAGGTGGDSSDAVAGKLYTELPETSFTRSISNPEAVMRRRRQQKL 240
            |.        |:||.|.:.....|||..:.....||..:|  ..|..||:|......||||||
Human   288 SR--------AASGGAALASPGPGTGSGAPAGSGGKERSE--NLSLRRSVSELSLQGRRRRQQ-- 340

  Fly   241 EKKLQQFRSRDGGPDTGGTLKIYGESLCQDVPYKTLLLSIRDCAQAVVREMLTKYGLEKADP--- 302
            |::.|......|..|                            ||           :..|||
Human   341 ERRQQALSMAPGAAD----------------------------AQ-----------IGTADPGDF 366

  Fly   303 --LHYCLVQVNSDGTEYILDDDECPLSILMNHPTSRGSIMFHVRRRPADSQPRRRKKKPLGAANG 365
              |..||:|..|:...::|         |..:..::..:::.:.|.
Human   367 DQLTQCLIQAPSNRPYFLL---------LQGYQDAQDFVVYVMTRE------------------- 403

  Fly   366 ANHISGDREGPVLVEVTHSGDGGRRIKLGSDPVEVGSANTNCLQLFGPSIQPRHCLISL-LEGVC 429
             .|:              .|.||.....|..|........|     .|.|.||||.:.. .|...
Human   404 -QHV--------------FGRGGNSSGRGGSPAPYVDTFLN-----APDILPRHCTVRAGPEHPA 448

  Fly   430 TVTPLHTDALTFVNGHHISQPTILHNGSVVMFGRVASYRFLDSPTDGRYNLALSQSQLDSACLYE 494
            .|.|.....:|. ||..:.:...||.|.::..|....:.:.|..|.|            |.....
Human   449 MVRPSRGAPVTH-NGCLLLREAELHPGDLLGLGEHFLFMYKDPRTGG------------SGPARP 500

  Fly   495 SRSPTSPGSWNDEDGALSSTHKSDYDHHQQANHSSAYHNNNNNSSDHPLSSTLRDVVDSKAGQDQ 559
            ...|..||:.....|...|.
Human   501 PWLPARPGATPPGPGWAFSC--------------------------------------------- 520

  Fly   560 GANSGNYDGQSLEGNLENETKSISSLKSGGSNSQDRSPKMTGSGILAGGGSGSGDTQGQEPILPA 624
                                                  ::.|.|:...|.:.:....|:||
Human   521 --------------------------------------RLCGRGLQERGEALAAYLDGREP---- 543

  Fly   625 VLEFPETHQELFLRHIISELDV---NVPHFKLAPVYSLYLCARYRASTHYRPELQPTERAHKLTM 686
            ||.|....:|..|..|:.....   ::|  .|.|...|.||.::.|        :..|..| |..
Human   544 VLRFRPREEEALLGEIVRAAAAGSGDLP--PLGPATLLALCVQHSA--------RELELGH-LPR 597

  Fly   687 FLHHVANLVYSVVQEQYTD-------------PRI-------------LAFWMANSSEFLHF--- 722
            .|..:|.|:...|.|:..:             |.:             |..||||::|.|.|
Human   598 LLGRLARLIKEAVWEKIKEIGDRQPENHPEGVPEVPLTPEAVSVELRPLMLWMANTTELLSFVQE 662

  Fly   723 --LKSDRHISAFSVQ----------AQEVLAEAVQTAFRNLVNCFRLELSQTLNQFLSENIDHDS 775
              |:.::.......|          |..:|.|.:...|:..|......|..||...|..|.....
Human   663 KVLEMEKEADQEDPQLCNDLELCDEAMALLDEVIMCTFQQSVYYLTKTLYSTLPALLDSNPFTAG 727

  Fly   776 A-------------AGL--VLTVLGSAMALLRRCRVNAALTIQLFSQLFHYINVICFNTIVANSQ 825
            |             .||  .|.|..:|:.|..:|.::..|..|.|..||.:.|....|:::...|
Human   728 AELPGPGAELGAMPPGLRPTLGVFQAALELTSQCELHPDLVSQTFGYLFFFSNASLLNSLMERGQ 792

  Fly   826 MCTG----DWGKVMTER--LQLLELWAERQGLELAADCHLAKINQCAQFLQAPKSSVEEIQQLAC 884
               |    .|.:.:..|  |.|:..|.:..||...|.....|::.....|..|::|   :.:.:.
Human   793 ---GRPFYQWSRAVQIRTNLDLVLDWLQGAGLGDIATEFFRKLSMAVNLLCVPRTS---LLKASW 851

  Fly   885 SCFR-----LNSLQMAALLQQEKL---------------PRNLVDTA------------------ 911
            |..|     |...|:..||...:|               .|..|||.
Human   852 SSLRTDHPTLTPAQLHHLLSHYQLGPGRGPPAAWDPPPAEREAVDTGDIFESFSSHPPLILPLGS 916

  Fly   912 --IRMAESVADELTRADGREVR 931
              :|:...|.|:....:.|.:|
Human   917 SRLRLTGPVTDDALHRELRRLR 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cno	NP_001303494.1	AF6_RA_repeat1	20..131	CDD:176377	27/138 (20%)
		AF6_RA_repeat2	257..346	CDD:176376	12/93 (13%)
		FHA	398..461	CDD:278899	16/63 (25%)
		Myo5p-like_CBD_afadin	631..941	CDD:271255	84/406 (21%)
		DegQ	<983..1112	CDD:223343
		PDZ	1009..1097	CDD:214570
RASIP1	NP_060275.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..118		1/1 (100%)
		RA	144..258	CDD:279168	24/136 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	267..356		29/128 (23%)
		Myo5p-like_CBD_Rasip1	551..913	CDD:271256	79/378 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910