DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cno and AFDN

DIOPT Version :9

Sequence 1:NP_001303494.1 Gene:cno / 40620 FlyBaseID:FBgn0259212 Length:2051 Species:Drosophila melanogaster
Sequence 2:XP_016866367.1 Gene:AFDN / 4301 HGNCID:7137 Length:1832 Species:Homo sapiens


Alignment Length:2196 Identity:712/2196 - (32%)
Similarity:1022/2196 - (46%) Gaps:534/2196 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 DREAVRSVIQQWNANRLDLFALSEPDENLLFHGVMRFYFQD-AGQKVATKCIRVASDATVTDVID 72
            :|..:..:|..|||||||||.:|:|.|:|.||||||||||| |....|||||||:|.||..|||:
Human     9 ERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIE 73

  Fly    73 TLIEKFRPDMRMLSVPNYALYEVHANGEERRLNADEKPLLVQLNWHIDDREGRFLLKNID----- 132
            ||.|||||||||||.|.|:|||||.:||||||:.|||||:|||||:.|||||||:|||.:     
Human    74 TLAEKFRPDMRMLSSPKYSLYEVHVSGEERRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPP 138

  Fly   133 ---QKTTPIEQTD----LNFKRKLSKREKKEQKKKEK----MAKLSSDPPTSNGSHLGLGNGVGA 186
               |...|.:|..    .||||.|||:||||:||:||    .|....|.|..       |..|  
Human   139 KKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQASDKDDRPFQ-------GEDV-- 194

  Fly   187 SSGSAHMNGNAGGTGGDSSDAVAGKLYTELPETSFTRSISNPEAVMRRRRQQKLEKKLQQFRSRD 251
                             .:..:|.::|.::|||||||:|||||.||:|||||||||::|:|||.|
Human   195 -----------------ENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSD 242

  Fly   252 GGPDTGGTLKIYGESLCQDVPYKTLLLSIRDCAQAVVREMLTKYGLEKADPLHYCLVQV------ 310
            |.||:||||:||.:||..::||||:|||..|.|...|.|.|.||||||.:|..||:.:|      
Human   243 GRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVMLPPGA 307

  Fly   311 -NSD---GTEYILDDDECPLSILMNHPTSRGSIMFHVRRRPADSQPRRRKKKPLG-AANGANHIS 370
             :||   ..|.|||||||||.|....|:.:|.::|.::|||.|..|::.||...| ...|.....
Human   308 QHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLEGKTPKGKERAD 372

  Fly   371 GDREG--------PVLVEVT------------HSGDGGR---------RIKLGSDPVEVGSANTN 406
            |...|        |.|||::            |:.:.|.         |::|....|.....:.|
Human   373 GSGYGSTLPPEKLPYLVELSPGRRNHFAYYNYHTYEDGSDSRDKPKLYRLQLSVTEVGTEKLDDN 437

  Fly   407 CLQLFGPSIQPRHCLISLLEGVCTVTPLHTDALTFVNGHHISQPTILHNGSVVMFGRVASYRFLD 471
            .:|||||.|||.||.::.::||.||||...||.|:|.|..||:.|:|.:|..|.||....::|:|
Human   438 SIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVD 502

  Fly   472 SPTDGRYNLALSQSQLDSACLYESRSPT-SPGSWND---------EDGALSSTHKS----DYDHH 522
            ...|.    ||::..:|...:.  :.|. .||...:         ..|....|.||    |.|..
Human   503 PSQDH----ALAKRSVDGGLMV--KGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRV 561

  Fly   523 QQANHSSAYHNNNNNSSDHPLSSTLRDVVDSKAGQDQGANSGNYDGQSLEGNLENETKSISSLKS 587
            ..|:                 |:..|.:|......:|   ..:|..|.                 
Human   562 SSAS-----------------STAERGMVKPMIRVEQ---QPDYRRQE----------------- 589

  Fly   588 GGSNSQDRSPKMTGSGILAGGGSGSGDTQGQEPILPAVLEFPETHQELFLRHIISELDVNVPHFK 652
              |.:||.|                    |.|.||||.:||.|:.::.||..||:..:.:..|||
Human   590 --SRTQDAS--------------------GPELILPASIEFRESSEDSFLSAIINYTNSSTVHFK 632

  Fly   653 LAPVYSLYLCARYRASTHYRPELQPTERAHKLTMFLHHVANLVYSVVQE-------QYTDPRILA 710
            |:|.|.||:..||..|..|||::.||||.||:...::.:.:::..|:||       |......||
Human   633 LSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQEVDQVDQKQKNIAGALA 697

  Fly   711 FWMANSSEFLHFLKSDRHISAFSVQAQEVLAEAVQTAFRNLVNCFRLELSQTLNQFLSE------ 769
            |||||:||.|:|:|.||.:|..::.||:|||..||.||:.||:|.:.||:..:..||.:      
Human   698 FWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSL 762

  Fly   770 ---NIDHDSAAGLVLTVLGSAMALLRRCRVNAALTIQLFSQLFHYINVICFNTIVA--NSQMCTG 829
               .||.      ||..|..||:|||||||||||||||||||||:||:..||.:|.  :|.:|:.
Human   763 QRPKIDD------VLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSH 821

  Fly   830 DWGKVMTERLQLLELWAERQGLELAADCHLAKINQCAQFLQAPKSSVEEIQQLACSCFRLNSLQM 894
            .||.::.::|..:|.|||:|||||||||||::|.|....|...|.:.::|..:..:||:|||||:
Human   822 YWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQL 886

  Fly   895 AALLQ-------QEKLPRNLVDTAIRMAESVADELTRADGREVRLEESPELHLALLLPDDGFSCD 952
            .||||       :..:|.:|::..:.:||:.||||.|:|||||:|||.|:|.|..|||:||:|||
Human   887 QALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCD 951

  Fly   953 VVRGIPTGLVDFLNPLQQQGMCRLAAQPTSIGLWTVYMHQFN-----ARSSSAMSNKL-PQPELQ 1011
            |||.||.||.:||:||.|:|.|||.....|.|.||:|....:     .|.::.::..| .:||:.
Human   952 VVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEII 1016

  Fly  1012 LIKLHKNSNGMGLSIVAAKGAGQEKLGIYIKSVVPGGAADADGRLQAGDQLLRVDGQSLIGITQE 1076
            .:.| |..|||||||||||||||:|||||:||||.|||||.||||.||||||.|||:||:|::||
Human  1017 TVTL-KKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQE 1080

  Fly  1077 RAADYLVRTGPVVSLEVAKQGAIYHGLATLLQQPSPVIQRGNRRMSERDLTRMGGAESTKSLGPL 1141
            |||:.:.||..||:|||||||||||||||||.||||::|    |:|:|   |..|....||.|..
Human  1081 RAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQ----RISDR---RGSGKPRPKSEGFE 1138

  Fly  1142 IANNHPNHSLSLSQHLNNSHNNTLGNSNNSSIINPLAAHLP-----NSKSVPALHHHTGSGTISL 1201
            :.||                     ::.|.|   |.:..||     ..|.:|      |...:..
Human  1139 LYNN---------------------STQNGS---PESPQLPWAEYSEPKKLP------GDDRLMK 1173

  Fly  1202 ANSKSRSTHSLHNNTSGMGGIGGAAAGGMLGQPNGSQNNANGNGNGNEQGFYQNLSVYRAQNQSQ 1266
            ..:..||:.::.|.....||....|:|      ..::..:...||            ...:.|:.
Human  1174 NRADHRSSPNVANQPPSPGGKSAYASG------TTAKITSVSTGN------------LCTEEQTP 1220

  Fly  1267 PILNERPPIAAHAAMNAYNGSSPLAPQQQPQQQQQSPYQQQQQQQHMQANANLPPTRPVSAYYHS 1331
            |...|..||........| .:.|.:..|......|:.:...:::.||..::|           ||
Human  1221 PPRPEAYPIPTQTYTREY-FTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSN-----------HS 1273

  Fly  1332 QQSAQQQLQQQQQQQQQHSLQQQQFALSSGNLNGQQQQQQQHQHQHQLTLNNRTKSQQNFQHT-- 1394
            ..:.|:..:.|::.::..:.|.::..:.:............:|..   :|::.|.||::..|:  
Human  1274 SIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSS---SLDSSTSSQEHLNHSSK 1335

  Fly  1395 --------------------------------LRMQQMMAPSMPNISNMYHHQ---QQQQQQLPL 1424
                                            :|......|..|.:    |:.   ......|||
Human  1336 SVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPV----HYAGDFDGMSMDLPL 1396

  Fly  1425 QQQQQQQQQPLMSSSQSMQNVNDFAGGYQNGSLEYRRSQLHDPSTLYEIQQQQLQQQQQQQQQQQ 1489
            .......|..|.|:              |..:.|.|:.:.|  ...||.::.:|::::::::::|
Human  1397 PPPPSANQIGLPSA--------------QVAAAERRKREEH--QRWYEKEKARLEEERERKRREQ 1445

  Fly  1490 QQQQASPNFIALPPKPLGSLQSPNKPNVPPSTAPKPQQDKPPLPPTATHPLFKATQQIAPGMNYV 1554
            :::.......:|.|.|..           |.||   ||.||..|.|...|.....:::.|...  
Human  1446 ERKLGQMRTQSLNPAPFS-----------PLTA---QQMKPEKPSTLQRPQETVIRELQPQQQ-- 1494

  Fly  1555 ASTLDPPKGSYVASNQGNNRPLHSGS----NPWEREEREKDLEMRREHIRQWREQQISELSQIVS 1615
            ..|::.....|:..::   ..|.||.    :||:|:.:||..:.::.||.....::|.||.....
Human  1495 PRTIERRDLQYITVSK---EELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPD 1556

  Fly  1616 RSPMQEEQLKTLILERDFERRAQELQEQEEQDQEQQYDKENVQELFRLAGGGQVSAIQTPITSYR 1680
            ||..:.::|:.|:||..|::|.||.::::|.|:|::.|..:...:.:.....:.:.:|   ...|
Human  1557 RSAEESDRLRKLMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQ---DEER 1618

  Fly  1681 QTEIKLAEMPDSNSLVDSVPPQPPAPTAQPLSSNTQQPKSILKHN-----RYSEGGVGPSGAPSS 1740
            :.:.:|.||....:          ...|:......:|.:...|.:     |..||          
Human  1619 RRQQQLEEMRKREA----------EDRARQEEERRRQEEERTKRDAEEKRRQEEG---------- 1663

  Fly  1741 PSKSQKSASFADERHLHTEHPISNLAKELNQLTM--LDKDNNNET-LDAVVPPPPPPERNSSYLI 1802
                ..|...|:.|..|.|.....|..|...|..  |.:|....: ..|...|||||:||:||  
Human  1664 ----YYSRLEAERRRQHDEAARRLLEPEAPGLCRPPLPRDYEPPSPSPAPGAPPPPPQRNASY-- 1722

  Fly  1803 MSQQKLRGSTGNATSSMGLLKTATSNQAAAAVEIKKASLLNTQTNNNNNLSGSLNNNTMHGSPLS 1867
                                                   |.||.                   ||
Human  1723 ---------------------------------------LKTQV-------------------LS 1729

  Fly  1868 AMELNAAYVSATGTGIIGGLGTPPPPPPLMQRDNKRVSFHDEENNFVSGNSQQQQLQQQYIMDNY 1932
            ...|..|                           |.|::::||.                     
Human  1730 PDSLFTA---------------------------KFVAYNEEEE--------------------- 1746

  Fly  1933 GMEHQDLDTIREDTSYLQHNLDASMLPSMPATPDAALWNTSVQSTPGVIGAQEVYRDPRTRRLAE 1997
                      .||.|....|       |.|.            ||...:||.:..||.:.:|   
Human  1747 ----------EEDCSLAGPN-------SYPG------------STGAAVGAHDACRDAKEKR--- 1779

  Fly  1998 KQQQQQQQRAGDAVPEKLSFKEKMKMFALESGEDKTPKDKLKISRAQRDID 2048
            .:.|..........||.|:|||:.::|:  .|:|.:  :|:|.||...:::
Human  1780 SKSQDADSPGSSGAPENLTFKERQRLFS--QGQDVS--NKVKASRKLTELE 1826

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cnoNP_001303494.1 AF6_RA_repeat1 20..131 CDD:176377 83/111 (75%)
AF6_RA_repeat2 257..346 CDD:176376 46/98 (47%)
FHA 398..461 CDD:278899 29/62 (47%)
Myo5p-like_CBD_afadin 631..941 CDD:271255 147/334 (44%)
DegQ <983..1112 CDD:223343 83/134 (62%)
PDZ 1009..1097 CDD:214570 62/87 (71%)
AFDNXP_016866367.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159023
Domainoid 1 1.000 163 1.000 Domainoid score I3980
eggNOG 1 0.900 - - E1_KOG1892
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 995 1.000 Inparanoid score I303
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006109
OrthoInspector 1 1.000 - - oto90538
orthoMCL 1 0.900 - - OOG6_105992
Panther 1 1.100 - - LDO PTHR10398
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2286
SonicParanoid 1 1.000 - - X5048
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.780

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