DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cno and Rasip1

DIOPT Version :9

Sequence 1:	NP_001303494.1	Gene:	cno / 40620	FlyBaseID:	FBgn0259212	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	XP_006229092.1	Gene:	Rasip1 / 292912	RGDID:	1305291	Length:	960	Species:	Rattus norvegicus

Alignment Length:	1040	Identity:	204/1040 - (19%)
Similarity:	310/1040 - (29%)	Gaps:	372/1040 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GVMRFYFQDAGQKVATKCIRVASDATVTDVIDTLIEKF-----RPDMRMLSVPNYALYEV----- 95
            ||::.:..........|.:.....:|..:::...:|::     |.......|..|||.:.
  Rat   142 GVLKIFAAGLASGANYKSVLATERSTARELVAEALERYGLTGGRGAGDSGCVDAYALCDALGRPA 206

  Fly    96 --HANGEER----RLNAD-EKPLLVQLNWHIDDREGRFLLKNIDQKTTPIEQTDLNFKRKLSKRE 153
              ...||.|    |:.|| |:|||||..|..  |.|                    :.|:...|.
  Rat   207 AGVGGGEWRAEHLRVLADAERPLLVQDLWRA--RPG--------------------WARRFELRG 249

  Fly   154 KKEQKKKEKMAKLSSDPPTSNG-SHLGLGNGVGASSGSAHMNGNAGGTGGDSSDAVAGKLYTELP 217
            ::|.::.|:.|..::|...:|. |.....|...|:||.|.:.....|:|..:.....||..:|
  Rat   250 REEARRLEQEAFGAADADGTNAPSWRTQKNRSRAASGGAALASPGPGSGSGTPTGSGGKERSE-- 312

  Fly   218 ETSFTRSISNPEAVMRRRRQQKLEKKLQQFRSRDGGPDTGGTLKIYGESLCQDVPYKTLLLSIRD 282
            ..|..||:|......||||||  |::.|......|..|            .|.||
  Rat   313 NLSLRRSVSELSLQGRRRRQQ--ERRQQALSMAPGAAD------------AQMVP---------- 353

  Fly   283 CAQAVVREMLTKYGLEKADPLHYCLVQVNSDGTEYILDDDECPLSILMNHPTSRGSIMFHVRRRP 347
                      |..|  ..|.|..||:|..|:...::|         |..:..::..:::.:.|.
  Rat   354 ----------TDPG--DFDQLTQCLIQAPSNRPYFLL---------LQGYQDAQDFVVYVMTRE- 396

  Fly   348 ADSQPRRRKKKPLGAANGANHISGDREGPVLVEVTHSGDGGRRIKLGSDPVEVGSANTNCLQLFG 412
                               .|:.| |.||      .|..||       .|........|     .
  Rat   397 -------------------QHVFG-RGGP------SSSRGG-------SPAPYVDTFLN-----A 423

  Fly   413 PSIQPRHCLISL-LEGVCTVTPLHTDALTFVNGHHISQPTILHNGSVVMFGRVASYRFLDSPTDG 476
            |.|.||||.:.. .|....|.|.....:|. ||..:.:...||.|.::..|....:.:.|....|
  Rat   424 PDILPRHCTVRAGPEPPAMVRPSRGAPVTH-NGCLLLREAELHPGDLLGLGEHFLFMYKDPRAGG 487

  Fly   477 RYNLALSQSQLDSACLYESRSPTSPGS------WNDEDGALSSTHKSDYDHHQQANHSSAYHNNN 535
                        |........|..||:      |                         |:
  Rat   488 ------------SGPARPPWLPARPGAAPPGPGW-------------------------AF---- 511

  Fly   536 NNSSDHPLSSTLRDVVDSKAGQDQGANSGNYDGQSLEGNLENETKSISSLKSGGSNSQDRSPKMT 600
                                                                        |.::.
  Rat   512 ------------------------------------------------------------SCRLC 516

  Fly   601 GSGILAGGGSGSGDTQGQEPILPAVLEFPETHQELFLRHIISELDV---NVPHFKLAPVYSLYLC 662
            |.|:...|.:.:....|:||    ||.|....:|..|..|:.....   ::|  .|.|...|.||
  Rat   517 GRGLQERGEALAAYLDGREP----VLRFRPREEEALLGEIVRAAASGAGDLP--PLGPATLLALC 575

  Fly   663 ARYRASTHYRPELQPTERAHKLTMFLHHVANLVYSVVQEQYTD-------------PRI------ 708
            .::.|        :..|..| |...|..:|.|:...|.|:..:             |.:
  Rat   576 VQHSA--------RELELGH-LPRLLGRLARLIKEAVWEKIKEIGDRQPENHPEGVPEVPLTPEA 631

  Fly   709 -------LAFWMANSSEFLHF----------------LKSDRHISAFSVQAQEVLA---EAVQTA 747
                   |..||||::|.|.|                |.||..:........|.||   |.:...
  Rat   632 VSVELRPLILWMANTTELLSFVQEKVLEMEKEADQEGLSSDPQLCNDLELCDEALALLDEVIMCT 696

  Fly   748 FRNLVNCFRLELSQTLNQFLSENIDHDSA-------------AGL--VLTVLGSAMALLRRCRVN 797
            |:..|......|..||...|..|.....|             .||  .|.|..:|:.|..:|.::
  Rat   697 FQQSVYYLTKTLYSTLPALLDSNPFTAGAELPGPGAELEAMPPGLRPTLGVFQAALELTSQCELH 761

  Fly   798 AALTIQLFSQLFHYINVICFNTIVANSQMCTG----DWGKVMTER--LQLLELWAERQGLELAAD 856
            ..|..|.|..||.:.|....|:::...|   |    .|.:.:..|  |.|:..|.:..||...|.
  Rat   762 PDLVSQTFGYLFFFSNASLLNSLMERGQ---GRPFYQWSRAVQIRTNLDLVLDWLQGAGLGDIAT 823

  Fly   857 CHLAKINQCAQFLQAPKSSVEEIQQLACSCFR-----LNSLQMAALLQQEKL------------- 903
            ....|::.....|..|::|   :.:.:.|..|     |...|:..||...:|
  Rat   824 EFFRKLSIAVNLLCVPRTS---LLKASWSSLRTDYPTLTPAQLHHLLSHYQLGPGRGPPPAWDPP 885

  Fly   904 --PRNLVDTA--------------------IRMAESVADELTRADGREVR-------LEESPELH 939
              .|:.|||.                    :|:...|.|:....:.|.:|       .:|.|..|
  Rat   886 PAERDAVDTGDIFESFSSHPPLILPLGSSRLRLTGPVTDDALHRELRRLRRLLWDLEQQELPANH 950

Fly 940 939
Rat 951 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cno	NP_001303494.1	AF6_RA_repeat1	20..131	CDD:176377	25/106 (24%)
		AF6_RA_repeat2	257..346	CDD:176376	13/88 (15%)
		FHA	398..461	CDD:278899	16/63 (25%)
		Myo5p-like_CBD_afadin	631..941	CDD:271255	89/425 (21%)
		DegQ	<983..1112	CDD:223343
		PDZ	1009..1097	CDD:214570
Rasip1	XP_006229092.1	Ubiquitin_like_fold	130..249	CDD:421700	26/128 (20%)
Rasip1	XP_006229092.1	Myo5p-like_CBD_Rasip1	544..910	CDD:271256	81/382 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910