DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cno and STXBP4

DIOPT Version :9

Sequence 1:	NP_001303494.1	Gene:	cno / 40620	FlyBaseID:	FBgn0259212	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	XP_016879899.1	Gene:	STXBP4 / 252983	HGNCID:	19694	Length:	571	Species:	Homo sapiens

Alignment Length:	741	Identity:	143/741 - (19%)
Similarity:	246/741 - (33%)	Gaps:	270/741 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   994 NARSSSAMSNKL--PQPELQLIKLHKNSNGMGLSIVAAKGAGQEKLGIYIKSVVPGGAADADGRL 1056
            |..:|:.:|..|  ..|..|:|.:.|.: |:||.::......:..| :||:.::|||....||||
Human     2 NKNTSTVVSPSLLEKDPAFQMITIAKET-GLGLKVLGGINRNEGPL-VYIQEIIPGGDCYKDGRL 64

  Fly  1057 QAGDQLLRVDGQSLIGITQERAADYLVRTGPVVSLEVAKQGAIYHGLATLLQQPSPVIQRGNRRM 1121
            :.||||:.|:.:|:||::.|.|...:  ||..:|..:.....|     ..::|.|..||..|
Human    65 KPGDQLVSVNKESMIGVSFEEAKSII--TGAKLSTRLESAWEI-----AFIRQKSDNIQPEN--- 119

  Fly  1122 SERDLTRMGGAESTKSLGPLIANNHPNHSLSLSQHLNNSHNNTLGNSNNSSIINPLAAHLPNSKS 1186
                |:.....|::...||..:      :|||                   ..:|....:|.:.|
Human   120 ----LSCTSLIEASGEYGPQAS------TLSL-------------------FSSPPEILIPKTSS 155

  Fly  1187 VPALHHHTGSGTISLANS-------KSRSTHSLHNNTSGMGGIGGAAAGGMLGQPNGSQNNANGN 1244
            .|..::...|....|:::       :|:...:.:|.|..:              |..|:|:..|.
Human   156 TPKTNNDILSSCELLSHTVRLIPGIQSKKIKTGYNKTVQI--------------PITSENSTVGL 206

  Fly  1245 GNGN-------EQGFYQNLSVYRAQNQSQPILNERPPIAAHAAMNAYNGSSPLAPQQQPQQQQQS 1302
            .|.:       ..|..:.:|:    |.|.....|:..:|.:     |.|..|
Human   207 SNTDVASAWTENYGLQEKISL----NPSVRFKAEKLEMALN-----YLGIQP------------- 249

  Fly  1303 PYQQQQQQQHMQANANLPPTRPVSAYYHSQQSAQQQLQQQQQQQQQHSLQQQQFALSSGNLNGQQ 1367
                 .::||                        |.|:||.|...:.::....|...:.||
Human   250 -----TKEQH------------------------QALRQQVQADSKGTVSFGDFVQVARNL---- 281

  Fly  1368 QQQQQHQHQHQLTLNNRTKSQQNFQHTLRMQQMMAPSMPNISNMYHHQQQQQQQLPLQQQQQQQQ 1432
                                     ..|::.::.. ....|||:.     ..|.||....:..:.
Human   282 -------------------------FCLQLDEVNV-GAHEISNIL-----DSQLLPCDSSEADEM 315

  Fly  1433 QPLMSSSQSMQNVNDFAGGYQNGSLEYRRSQLHDPSTLYE-IQQQQLQQQQQQQQQQQQQQQASP 1496
            :.|...                     |...|.:.:||.| :.:...|::|..::.|..:|:|
Human   316 ERLKCE---------------------RDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEA-- 357

  Fly  1497 NFIALPPKPLGSLQSPNKPNVPPSTAPKPQQDKPPLPPTATHPLFKATQQIAPGMNYVASTLDPP 1561
                             |..|..:.|.:          :..| |.:|.|:.|.||
Human   358 -----------------KAVVEETRALR----------SRIH-LAEAAQRQAHGM---------- 384

  Fly  1562 KGSYVASNQGNNRPLHSGSNPWEREEREKDLEMRREHIRQWREQQISEL-SQIVSRSPMQEE--- 1622
                                           ||..|.:.:..|.:|:|| :|:...|...:|
Human   385 -------------------------------EMDYEEVIRLLEAKITELKAQLADYSDQNKESVQ 418

  Fly  1623 QLKTLILERDFERRAQELQEQ--EEQDQEQQYDKENVQELF--------RLAGGGQVSAIQTPIT 1677
            .||..|:..|.:.|..|:..:  |...::..:..|.:||:|        .|:....|.|.||.:|
Human   419 DLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLT 483

  Fly  1678 ----SYRQTEIKLAEMPDSNSLVDSV 1699
                :.|.....||  .:|..||.||
Human   484 PLGRNGRSIPATLA--LESKELVKSV 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cno	NP_001303494.1	AF6_RA_repeat1	20..131	CDD:176377
		AF6_RA_repeat2	257..346	CDD:176376
		FHA	398..461	CDD:278899
		Myo5p-like_CBD_afadin	631..941	CDD:271255
		DegQ	<983..1112	CDD:223343	36/119 (30%)
		PDZ	1009..1097	CDD:214570	29/87 (33%)
STXBP4	XP_016879899.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1892
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900