DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cno and Stxbp4

DIOPT Version :9

Sequence 1:	NP_001303494.1	Gene:	cno / 40620	FlyBaseID:	FBgn0259212	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	NP_035635.1	Gene:	Stxbp4 / 20913	MGIID:	1342296	Length:	557	Species:	Mus musculus

Alignment Length:	474	Identity:	97/474 - (20%)
Similarity:	165/474 - (34%)	Gaps:	125/474 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   994 NARSSSAMSNKLPQPELQLIKLHKNSNGMGLSIVAAKGAGQEKLGIYIKSVVPGGAADADGRLQA 1058
            :|||||.:..   .|..::|.:.|.: |:||.|:......:..| :||..|:|||....||||:.
Mouse     7 SARSSSPLDR---DPAFRVITVTKET-GLGLKILGGINRNEGPL-VYIHEVIPGGDCYKDGRLKP 66

  Fly  1059 GDQLLRVDGQSLIGITQERAADYLVRT----------------------------GPVVSLEVAK 1095
            ||||:.::.:|:||::.|.|...:.|.                            .|.||.:...
Mouse    67 GDQLVSINKESMIGVSFEEAKSIITRAKLRSESPWEIAFIRQKSYCGHPGNICCPSPQVSEDCGP 131

  Fly  1096 QGAIYHGLATLLQQPSPVIQRGNRRMSERDLTRMGGAESTKSLGPLIANNHPNHSLSLSQHLNNS 1160
            |.:.:    |||..||..:.   .:.|....|:.....|.|::     ...|.|..:....:.:.
Mouse   132 QTSTF----TLLSSPSETLL---PKTSSTPQTQDSTFPSCKAI-----QTKPEHDKTEHSPITSL 184

  Fly  1161 HNNTLGNSNNSSIINPLAAHLPNSKSVPALHHHTGSGTISLANSKSRSTHSLHNNTSGMGGIGGA 1225
            .|:....||..     :|....:..|.|       .|.|||..|.......|.
Mouse   185 DNSPADTSNAD-----IAPAWTDDDSGP-------QGKISLNPSVRLKAEKLE------------ 225

  Fly  1226 AAGGMLG-QPNGSQN-------NANGNGNGNEQGFYQ-------------NLSVYR----AQNQS 1265
            .|...|| ||...|.       .|:..|..:...|.|             |:.|:.    ..:|.
Mouse   226 MALNYLGIQPTKEQREALREQVQADSKGTVSFGDFVQVARSLFCLQLDEVNVGVHEIPSILDSQL 290

  Fly  1266 QP-----------ILNERPPIAAHAAMNAYNGSSPLAPQQQPQQQQQSPYQQQQQQQHMQANANL 1319
            .|           :..||     :||:...|   .|..:....::.:....::.|....:|.|..
Mouse   291 LPCDSLEADEVGKLRQER-----NAALEERN---VLKEKLLESEKHRKQLIEELQNVKQEAKAVA 347

  Fly  1320 PPTRPVSAYYHSQQSAQQQLQQQQQQQQQHSLQ---QQQFALSSGNLNGQQQQQQQHQHQHQLTL 1381
            ..||.:.:..|..::|         |:|.|.::   ::...|....::..:.|...:..|::.::
Mouse   348 EETRALRSRIHLAEAA---------QRQAHGMEMDYEEVIRLLEAEVSELKAQLADYSDQNKESV 403

  Fly  1382 NNRTKSQQNFQHTLRMQQM 1400
            .:..|........||..:|
Mouse   404 QDLRKRVTVLDCQLRKSEM 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cno	NP_001303494.1	AF6_RA_repeat1	20..131	CDD:176377
		AF6_RA_repeat2	257..346	CDD:176376
		FHA	398..461	CDD:278899
		Myo5p-like_CBD_afadin	631..941	CDD:271255
		DegQ	<983..1112	CDD:223343	41/145 (28%)
		PDZ	1009..1097	CDD:214570	30/115 (26%)
Stxbp4	NP_035635.1	PDZ_signaling	21..94	CDD:238492	27/74 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..214		17/91 (19%)
		Luteo_P1-P2	<189..393	CDD:285641	43/244 (18%)
		WW	502..531	CDD:278809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1892
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900