DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cno and Afdn

DIOPT Version :9

Sequence 1:	NP_001303494.1	Gene:	cno / 40620	FlyBaseID:	FBgn0259212	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	XP_006523815.1	Gene:	Afdn / 17356	MGIID:	1314653	Length:	1917	Species:	Mus musculus

Alignment Length:	2216	Identity:	728/2216 - (32%)
Similarity:	1053/2216 - (47%)	Gaps:	489/2216 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DREAVRSVIQQWNANRLDLFALSEPDENLLFHGVMRFYFQD-AGQKVATKCIRVASDATVTDVID 72
            :|..:..:|..|||||||||.:|:|.|:|.||||||||||| |....|||||||:|.||..|||:
Mouse     9 ERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIE 73

  Fly    73 TLIEKFRPDMRMLSVPNYALYEVHANGEERRLNADEKPLLVQLNWHIDDREGRFLLKNID----- 132
            ||.|||||||||||.|.|:|||||.:||||||:.|||||:|||||:.|||||||:|||.:
Mouse    74 TLAEKFRPDMRMLSSPKYSLYEVHVSGEERRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPA 138

  Fly   133 ---QKTTPIEQTD----LNFKRKLSKREKKEQKKKEKMAKLSSDPPTSNGSHLGLGNGVGASSGS 190
               |...|.:|..    .||||.|||:||||:|||||.|...:.......|.
Mouse   139 KKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKKEKEALRQASDKEERPSQ------------- 190

  Fly   191 AHMNGNAGGTGGDSSDA-VAGKLYTELPETSFTRSISNPEAVMRRRRQQKLEKKLQQFRSRDGGP 254
                      |.||.:: :|.::|.::|||||||:|||||.||:|||||||||::|:|||.||.|
Mouse   191 ----------GDDSENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRP 245

  Fly   255 DTGGTLKIYGESLCQDVPYKTLLLSIRDCAQAVVREMLTKYGLEKADPLHYCLVQV-------NS 312
            |:||||:||.:||..::||||:|||..|.|...|.|.|.||||||.:|..||:.:|       :|
Mouse   246 DSGGTLRIYADSLKPNIPYKTILLSTTDTADFAVAESLEKYGLEKENPKDYCIARVMLPPGAQHS 310

  Fly   313 D---GTEYILDDDECPLSILMNHPTSRGSIMFHVRRRPADSQPRRRKKKPLG-AANGANHISGDR 373
            |   ..|.|||||||||.|....|:.:|.::|.::|||.|..|::.||...| :..|.:...|..
Mouse   311 DERGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDYIPKKMKKHVEGKSLKGKDRADGSG 375

  Fly   374 EG--------PVLVEVT------------HSGDGGR---------RIKLGSDPVEVGSANTNCLQ 409
            .|        |.|||::            |:.:.|.         |::|....|.....:.|.:|
Mouse   376 YGSALPPEKLPYLVELSPGRRNHFAYYSYHTYEDGSDSRDKPKLYRLQLSVTEVGTEKFDDNSIQ 440

  Fly   410 LFGPSIQPRHCLISLLEGVCTVTPLHTDALTFVNGHHISQPTILHNGSVVMFGRVASYRFLDSPT 474
            ||||.|||.||.::.::||.||||...||.|:|:|..||:.|:|.:|..:.||....::|:|...
Mouse   441 LFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVDGQRISETTMLQSGMRLQFGTSHVFKFVDPIQ 505

  Fly   475 DGRYNLALSQSQLDSACLYESRSPT-SPGSWNDEDGALSSTHKSDYDHHQ----QANHSSAYHNN 534
            |.    .||:..:|...:.  :.|. .||:..:      :|.:...|.|.    .|:.|:...::
Mouse   506 DH----VLSKRSVDGGLMV--KGPRHKPGAVQE------TTFELGGDVHSGTALPASRSTTRLDS 558

  Fly   535 NNNSSDHPLSSTL-RDVVDSKAGQDQGANSGNYDGQSLEGNLENETKSISSLKSGGSNSQDRSPK 598
            :..||   .|||. |.:|......||         :......||.|:
Mouse   559 DRVSS---ASSTAERGMVKPMIRLDQ---------EQEYRRRENRTQ------------------ 593

  Fly   599 MTGSGILAGGGSGSGDTQGQEPILPAVLEFPETHQELFLRHIISELDVNVPHFKLAPVYSLYLCA 663
                           |..|.|.||||.:||.|:.::.||..||:..:.:..||||:|.|.||:..
Mouse   594 ---------------DATGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMAC 643

  Fly   664 RYRASTHYRPELQPTERAHKLTMFLHHVANLVYSVVQE-------QYTDPRILAFWMANSSEFLH 721
            ||..|:.:||::.||||.||....::.:.:::..|:||       |......|||||||:||.|:
Mouse   644 RYVLSSQHRPDISPTERTHKAIAVVNKMVSMMEGVIQEVDQVDQKQKNIAGALAFWMANASELLN 708

  Fly   722 FLKSDRHISAFSVQAQEVLAEAVQTAFRNLVNCFRLELSQTLNQFLSE---------NIDHDSAA 777
            |:|.||.:|..::.||:|||..||.||:.||:|.:.||:..:..||.:         .||.
Mouse   709 FIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDD---- 769

  Fly   778 GLVLTVLGSAMALLRRCRVNAALTIQLFSQLFHYINVICFNTIVA--NSQMCTGDWGKVMTERLQ 840
              ||..|..||:|||||||||||||||||||||:||:..||.:|.  :|.:|:..||.::.::|.
Mouse   770 --VLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLG 832

  Fly   841 LLELWAERQGLELAADCHLAKINQCAQFLQAPKSSVEEIQQLACSCFRLNSLQMAALLQ------ 899
            .:|.|||:|||||||||||::|.|....|...|...::|..:..:||:|||||:.||||
Mouse   833 HIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYVPDDIPNINSTCFKLNSLQLQALLQNYHCAP 897

  Fly   900 -QEKLPRNLVDTAIRMAESVADELTRADGREVRLEESPELHLALLLPDDGFSCDVVRGIPTGLVD 963
             :..:|.:|::..:.:||:.||||.|:|||:|:|||.|:|.|..|||:||:||||||.||.||.:
Mouse   898 DEPFIPTDLIENVVAVAENTADELARSDGRDVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQE 962

  Fly   964 FLNPLQQQGMCRLAAQPTSIGLWTVYMHQFN-----ARSSSAMSNKL-PQPELQLIKLHKNSNGM 1022
            ||:||.|:|.|||.....|.|.||:|....:     .|.::.::..| .:||:..:.| |..|||
Mouse   963 FLDPLCQRGFCRLVPHTRSPGTWTIYFEGADYESHLMRENAELAQPLRKEPEIITVTL-KKQNGM 1026

  Fly  1023 GLSIVAAKGAGQEKLGIYIKSVVPGGAADADGRLQAGDQLLRVDGQSLIGITQERAADYLVRTGP 1087
            ||||||||||||:|||||:||||.|||||.||||.||||||.|||:||:|::|||||:.:.||..
Mouse  1027 GLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSS 1091

  Fly  1088 VVSLEVAKQGAIYHGLATLLQQPSPVIQRGNRRMSERDLTRMGGAESTKSLGPLIANNHPNHSLS 1152
            ||:|||||||||||||||||.||||::|    |:|:|   |..|....||.|..:.||
Mouse  1092 VVTLEVAKQGAIYHGLATLLNQPSPMMQ----RISDR---RGSGKPRPKSEGFELYNN------- 1142

  Fly  1153 LSQHLNNSHNNTLGNSNNSSIINPLAAHLP-----NSKSVPALHHHTGSGTISLANSKSRSTHSL 1212
                          ::.|.|   |.:..:|     ..|.:|      |...:....:..||:.::
Mouse  1143 --------------SAQNGS---PESPQMPWTEYSEPKKLP------GDDRLMKNRADHRSSPNV 1184

  Fly  1213 HNNTSGMGGIGGAAAGGMLGQPNGSQNNANGNGNGNEQGFYQNLSVYRAQNQSQPILNERPPIAA 1277
            .|.....||.|...:|      ..::..:...||            ...:.||.|...|..||..
Mouse  1185 ANQPPSPGGKGPYTSG------TAAKITSVSTGN------------LCTEEQSPPPRPEAYPIPT 1231

  Fly  1278 HAAMNAYNGSSPLAPQQQPQQQQQSPYQQQQQQQHMQANANLPPTRPVSAYYHSQQSAQQQLQQQ 1342
            ......| .:.|.:..|......||.:...:::.|:...:|           ||..:.|:..:.|
Mouse  1232 QTYTREY-FTFPASKSQDRMAPPQSQWPNYEEKPHVHTESN-----------HSSIAIQRVTRSQ 1284

  Fly  1343 QQQQQQHSLQQQQFALSSGNLNGQQQQQQQHQHQHQLTLNNRTKSQQNFQHTLR----------- 1396
            ::.:::...|.::..:.:|...........:|..   ::.:.|.||::..|:.:
Mouse  1285 EELREEKVYQLERHRVEAGMDRKCDSDMWINQSS---SVESSTSSQEHLNHSSKSVTPASTLTKS 1346

  Fly  1397 -----------MQQMMAPSMPNISNM--------YHHQQQQQ---QQLPLQQQQQQQQQPLMSSS 1439
                       :...:|.|.|..:::        .|:..:..   ..|||......|..|
Mouse  1347 GPGRWKTPAAVLPTPVAVSQPIRTDLPPPPPPPPVHYTSEFDGIPMDLPLPPPPANQAGP----- 1406

  Fly  1440 QSMQNVNDFAGGYQNGSLEYRRSQLHDPSTLYEIQQQQLQQQQQQQQQQQQQQQASPNFIALPPK 1504
            ||.          |..:.|:::.:.|  ...||.::.:|::::::::::|:::
Mouse  1407 QSA----------QVAAAEWKKREEH--QRWYEKEKARLEEERERKRREQERK------------ 1447

  Fly  1505 PLGSLQSPNKPNVPPSTAPKPQQDKPPLPPTATHPLFKATQQIAPGMNYVASTLDPPKGSYVASN 1569
             ||.::|....  |.|.:|...|.||..|.|...|.....:::.|...  ..|::.....|:..:
Mouse  1448 -LGQMRSQTLN--PASFSPLATQAKPEKPSTLQRPQETVIRELQPQQQ--PRTIERKDLQYITIS 1507

  Fly  1570 QGNNRPLHSGS----NPWEREEREKDLEMRREHIRQWREQQISELSQIVSRSPMQEEQLKTLILE 1630
            :   ..|.||.    :||:|:.|||..:.::.||.....::|.||...|.|:..:.::|:.|:||
Mouse  1508 K---EELSSGDSLSPDPWKRDAREKLEKQQQMHIVDMLSKEIHELQNKVDRTAEESDRLRKLMLE 1569

  Fly  1631 RDFERRAQE-LQEQEEQDQEQQYDKENVQELFRLAGGGQVSAIQTPITSY--------RQTEIKL 1686
            ..|::|.|| .|:.|:.|:|:..|.:.:..:.||....:......|..|.        |:.:.:|
Mouse  1570 WQFQKRLQESKQKDEDDDEEEDDDVDTMLIMQRLEAERRARQTAMPAISVLDLMQDEERRRQQQL 1634

  Fly  1687 AEMPDSNSLVDSVPPQPPAPTAQPLSSNTQQPKSILK----HNRYSEGGVGPSGAPSSPSKSQKS 1747
            .|| ......|.|        .|......|:.:.:.:    ..|..||              ..|
Mouse  1635 EEM-RKREAEDRV--------RQEEDGRHQEEERVKRDAEEKRRQEEG--------------YYS 1676

  Fly  1748 ASFADERHLHTEHPISNLAKELNQLTM--LDKDNNNETL-DAVVPPPPPPERNSSYL---IMSQQ 1806
            ...|:.|..|.|.....|..|...|:.  |.:|....:| .|...|||||:||:|||   ::|..
Mouse  1677 RLEAERRRQHEEAARRLLEPEEPGLSRPPLPRDYEPPSLSSAPCAPPPPPQRNASYLKTQVLSPD 1741

  Fly  1807 KL--------------RGSTG-----NATSSMGLLKTATSNQAAAAVEIKKASLLNTQTNNNNNL 1852
            .|              .|..|     :...|.|.|..||........:.:.||       :..:|
Mouse  1742 SLFTAKFVAYDEEEEDYGPAGQDKYPSTRKSHGHLPLATLKPQQPPCQPRPAS-------DGISL 1799

  Fly  1853 SGSLNNNTMHGSPLSAMELNAAYVSATGTGIIGGLGTPPPPPPLMQRDNKRVSFHDEENNFVSGN 1917
            ..|.       .|..|...:.||.:          |.|||
Mouse  1800 CNSF-------QPPLAKANSTAYKA----------GQPPP------------------------- 1822

  Fly  1918 SQQQQLQQQYIMDNYGMEHQDLDTIREDTSYLQHNLDASMLPSMPATPDAALW-----NTSVQST 1977
                                                    ||..|:......|     |:...|.
Mouse  1823 ----------------------------------------LPGKPSLYRPGHWKGRGPNSYSGSA 1847

  Fly  1978 PGVIGAQEVYRDPRTRRLAEKQQQQQQQRAGDAVPEKLSFKEKMKMFALESGEDKTPKDKLKISR 2042
            ...:||   |..||..|....:.|..........||.|:|||:.::|:  .|:|.:  ||:|.||
Mouse  1848 GTAVGA---YDAPREAREKLTRSQDADLPGSSGAPENLTFKERQRLFS--QGQDVS--DKVKASR 1905

  Fly  2043 AQRDID 2048
            ...:::
Mouse  1906 KLTELE 1911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cno	NP_001303494.1	AF6_RA_repeat1	20..131	CDD:176377	83/111 (75%)
		AF6_RA_repeat2	257..346	CDD:176376	46/98 (47%)
		FHA	398..461	CDD:278899	28/62 (45%)
		Myo5p-like_CBD_afadin	631..941	CDD:271255	145/334 (43%)
		DegQ	<983..1112	CDD:223343	83/134 (62%)
		PDZ	1009..1097	CDD:214570	62/87 (71%)
Afdn	XP_006523815.1	RA1_Afadin	20..132	CDD:340480	83/111 (75%)
		RA2_Afadin	248..348	CDD:340479	47/99 (47%)
		FHA	418..500	CDD:238017	32/81 (40%)
		Myo5p-like_CBD_afadin	612..940	CDD:271255	145/333 (44%)
		PDZ	1016..1098	CDD:366185	58/82 (71%)
		DUF5401	<1465..1717	CDD:375164	64/279 (23%)
		ARGLU	<1599..1698	CDD:373772	21/121 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849405
Domainoid	1	1.000	160	1.000	Domainoid score	I4051
eggNOG	1	0.900	-	-		E1_KOG1892
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	959	1.000	Inparanoid score	I332
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006109
OrthoInspector	1	1.000	-	-		oto94127
orthoMCL	1	0.900	-	-		OOG6_105992
Panther	1	1.100	-	-	LDO	PTHR10398
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2286
SonicParanoid	1	1.000	-	-		X5048
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780