DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cno and afd-1

DIOPT Version :9

Sequence 1:NP_001303494.1 Gene:cno / 40620 FlyBaseID:FBgn0259212 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_001021660.2 Gene:afd-1 / 171776 WormBaseID:WBGene00021009 Length:1660 Species:Caenorhabditis elegans


Alignment Length:2188 Identity:559/2188 - (25%)
Similarity:840/2188 - (38%) Gaps:689/2188 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 DREAVRSVIQQWNANRLDLFALSEPDENLLFHGVMRFYFQDAGQKVATKCIRVASDATVTDVIDT 73
            :||.:..::||||.||||||.||.|.|:|...|||||||||.|:||.|||:||:|.||...|:|.
 Worm     4 EREQLACLVQQWNENRLDLFHLSYPTEDLEVEGVMRFYFQDGGEKVLTKCVRVSSTATTRAVVDA 68

  Fly    74 LIEKFRPDMRMLSVPNYALYEVHANGEERRLNADEKPLLVQLNWHIDDREGRFLLK--------- 129
            |.|||.||::|||...|:|:|||.|||||:|..:||||:|||.||.||||||||||         
 Worm    69 LSEKFLPDLKMLSNDTYSLWEVHENGEERKLLDEEKPLVVQLQWHKDDREGRFLLKKDAAPPVSL 133

  Fly   130 ----NIDQKTTPIEQTDLNFKRKLSKREKKEQKKKEKMAKLSSDPPTSNGSHLGLGNGVGASSGS 190
                ..|||.|           :.:|::.||.|||.:.                  |.|     |
 Worm   134 LNLQEADQKNT-----------RFAKKKDKEPKKKNQK------------------NFV-----S 164

  Fly   191 AHMNGNAGGTGGDSSDAVAGKLYTELPETSFTRSISNPEAVMRRRRQQKLEKKLQQFRSRDGGPD 255
            ..:||  |.....|.|    .:|.::|..:|||:|||||||||:||::|||.||::..       
 Worm   165 VQVNG--GREEAQSQD----DIYKQVPFNTFTRTISNPEAVMRKRREKKLETKLKEMM------- 216

  Fly   256 TGGTLKIYGESLCQDVPYKTLLLSIRDCAQAVVREMLTKYGLE--KADPLHYCLVQVNSDGTEYI 318
            .||:||:||..:....||.::|..|.:.|..::...|.|||||  |.|   :.||:|::|.....
 Worm   217 FGGSLKVYGGEIVPTRPYVSILAEINENADRILGAALEKYGLEHSKDD---FILVEVSNDDDRKS 278

  Fly   319 LDD-----------DECPLSILMNHPTSRGSIMFH----VRRRPADSQ-PRRRKKKPLGAANGAN 367
            :.|           .|||| ..|...:..|...|.    ::|:|.|.| |......|.......:
 Worm   279 MSDLREIDGRPIPPTECPL-FEMTARSGNGENGFDSFLAIKRKPHDYQVPSTSVVAPSSVTLPMS 342

  Fly   368 HISG----DREGPVLVEVTHSGD-GGRRIKLGSDPVEVGSAN--TNCLQ----LFGPSIQPRHCL 421
            .::.    ....|||:.:.:.|. ...||.|.....||||.:  :|..|    |.||.|:.||..
 Worm   343 PLTSLPPQIHNLPVLIVMNNDGHLSTHRITLHEGVTEVGSDSQMSNFSQHNIYLDGPDIRGRHAA 407

  Fly   422 ISLLEGVCTVTPLHTDALTFVNGHHISQPTILHNGSVVMFGRVASYRFLDSPTDGRYNLALSQSQ 486
            |:.:|||.|:||...||...||||.:.|..||.:|..:..|...|::|                 
 Worm   408 IAFMEGVVTLTPSTRDAYLEVNGHQLMQTEILRDGDHIRIGADHSFKF----------------- 455

  Fly   487 LDSACLYESRSPTSPGSWNDEDGALSSTHKSDYDHHQQANHSSAYHNNNNNSSDHPLSSTLRDVV 551
                                      ||..|      |||..::.:.:|:|.......:...::.
 Worm   456 --------------------------STSSS------QANQINSTNISNSNQRHFQQQTFYPEMA 488

  Fly   552 DSKAGQDQGANS--------GNYDGQSLEGNLENETKSISSLKSGG----SNSQDRSPKMTGSGI 604
            ||:|...:.|.|        .:|...|:.|:      |:||.:...    ||:....|..|.|  
 Worm   489 DSRASTARCAPSDYCSLPQQNDYYPPSMSGS------SVSSSRQEDLMMHSNNNILPPYSTKS-- 545

  Fly   605 LAGGGSGSGDTQGQEPI-LPAVLEFPETHQELFLRHIISE---LDVNVPHFKLAPVYSLYLCARY 665
                        .|||: ||..::..:.:...||..::|.   ....:..|:|:|.|||||..| 
 Worm   546 ------------AQEPLQLPLSIQIGDYNVWDFLAEVMSNRAATSSEMSTFRLSPAYSLYLALR- 597

  Fly   666 RASTHYRPELQPTERAHKLTMFLHHVANLVYSVVQEQYTDPRILAFWMANSSEFLHFLKSDRHIS 730
            ...||.:|        :.:..|....:|  :..:.::.:....|.||:||:|||.|.::.|..:.
 Worm   598 SFHTHNKP--------YSVQFFSRIESN--FKQIAQECSSKDDLIFWLANASEFNHLVERDTELK 652

  Fly   731 A-----FSVQAQEVLAEAVQTAFRNLVNCFRLELSQTLNQFLSENI-DHDSAAGLVLTVLGSAMA 789
            |     .||:.:.:        ||.||...:..:.......|..:: ||| |.|.|:.:|.:.|.
 Worm   653 ASRYGKISVEIERI--------FRRLVAVLQSVIRPAARALLDIHLNDHD-ATGDVIHLLDTTMR 708

  Fly   790 LLRRCRVNAALTIQLFSQLFHYINVICFNTIVA--------NSQMCTGDWGKVMTERLQLLELWA 846
            ..|.|.:||||||||...|.|.:|...||::|:        |:::     ||.:..|::.:..:.
 Worm   709 QARICGLNAALTIQLCGHLLHMVNAFVFNSLVSVNLPAAQLNTRL-----GKCLQYRIESIHRFC 768

  Fly   847 ERQGLELAADCHLAKINQCAQFLQAPKSSVEEIQQLACSCFRLNSLQMAALL-----QQEKLP-- 904
            ||.|:|:||:|||.:..|.|..|...|:   ::..|..:|::|||||:..:|     ...::|  
 Worm   769 ERMGVEMAAECHLDRSRQAANLLATQKN---DVAALGSTCYKLNSLQVVHILSGFEPDDGEIPCD 830

  Fly   905 RNLVDTAIRMAESVADELTRADGREVRLEESPELHLALLLPDDGFSCDVVRGIPTGLVDFLNPLQ 969
            .::||...|:||..||:||..||:.|.||||.||:|..|:|.||:..:..|.:|.||..:|..||
 Worm   831 DDVVDRICRLAEKQADKLTLEDGQRVTLEESDELNLPFLIPQDGYFVEQFRTVPDGLWQYLQQLQ 895

  Fly   970 QQGMCRLA----AQPTS---------IGLWTVYMH--------------------------QFNA 995
            .:.:|...    |.|.:         ||....:.|                          ||..
 Worm   896 HRRLCHTVSLTPAPPAAMTHSMHAMHIGASDAHYHQHQHQQQQNPIVRSVSQTTLTSIPTTQFGD 960

  Fly   996 RSSSAMSNKLPQPELQLIKLHKNSNGMGLSIVAAKGAGQEKLGIYIKSVVPGGAADADGRLQAGD 1060
            ...||:|:.:.:     :.|.||..|:|||||||:|.|..::|||:|.||.|..|..||||:.||
 Worm   961 SFGSAVSDTISK-----VTLRKNGGGIGLSIVAAQGVGDRQMGIYVKKVVEGTPAAHDGRLETGD 1020

  Fly  1061 QLLRVDGQSLIGITQERAADYLVRTGPVVSLEVAKQGAIYHGLATLLQQPSPVIQRGNRRMSERD 1125
            |||.|:|.|||||:||.||..:.::|..|..:|.|:.|..:||:..|...:|             
 Worm  1021 QLLSVNGHSLIGISQEDAARLMTQSGNEVHFDVRKRAAHRNGLSNWLGSQTP------------- 1072

  Fly  1126 LTRMGGAESTKSLGPLIANNHPNHSLSLSQHLNNSHNNTLGNSNNSSIINPLAAHLPNSKSVPAL 1190
                                                       ..|:.|.|..:.:|     |..
 Worm  1073 -------------------------------------------TTSNFIAPSPSTVP-----PPS 1089

  Fly  1191 HHHTGSGTISLANSKSRSTHSLHNNTSGMGGIGGAAAGGMLGQPNGSQNNANGNGNGNEQGFYQN 1255
            :.|.|            .|.|..                  |||..|.|:.||..:|        
 Worm  1090 YSHVG------------RTPSYD------------------GQPPPSYNHRNGGASG-------- 1116

  Fly  1256 LSVYRAQNQSQPILNERPPIAAHAAMNAYNGSSPLAPQQQPQQQQQSPYQQQQQQQH-MQANANL 1319
                                   |..::...|:.:||.........|.:.||....| |..|.||
 Worm  1117 -----------------------AGGSSGRNSAFVAPLSNSSSNASSSHMQQHYAHHNMMHNGNL 1158

  Fly  1320 --PPTRPVSAYYHSQQSAQQQLQQQQQQQQQHSLQQQQFALSSGNLNGQQQQQ------QQHQHQ 1376
              .|..|.....|.:.|:...||.....           :.|..::.|..:..      ..::|.
 Worm  1159 SAAPGAPAGDPKHYRSSSASDLQHDPNA-----------SFSQSSMTGSARSSVFDKLPSHYRHS 1212

  Fly  1377 HQLTLNNRTKSQQNFQHTLRMQQMMAPSMPNISNMYHHQQQQQQQLPLQQQQQQQQQPLMSSSQS 1441
            .:.|:...|:........||.....:|    :||:|                    :|..:|   
 Worm  1213 TRPTVIQPTRPSAQSPSALRKAAAASP----VSNLY--------------------RPTSAS--- 1250

  Fly  1442 MQNVNDFAGGYQNGSLEYRRSQLHDPSTLYEIQQQQLQQQQQQQQQQQQQQQASPNFIALPPKPL 1506
                |.||....:|.|....|.....||      |.:.:.....:......:::||         
 Worm  1251 ----NLFAPPRNSGGLVGYSSNAAREST------QDIHRALNDLELNSPLARSTPN--------- 1296

  Fly  1507 GSLQSPNKPNVPPSTAPKPQQDKPPLPPTATHPLFKATQQIAPGMNY------VASTLDP-PKGS 1564
                  .:..:||...|         ..|:|...:.....|.|...|      .::|:.| ||| 
 Worm  1297 ------EEYRIPPPRVP---------TVTSTSSNYAPLHSIRPASMYGYQSPSSSTTVIPAPKG- 1345

  Fly  1565 YVASNQGNNRPLHSGSNPWEREEREKDLEMRREHIRQWREQQISELSQIVSRSPMQEEQLKTLIL 1629
             |||:..|..|                    |.::                          ||  
 Worm  1346 -VASSSNNTSP--------------------RVNV--------------------------TL-- 1361

  Fly  1630 ERDFERRAQELQEQEEQDQEQQYDKENVQELFRLAGGGQVSAIQTPITSYRQTEIKLAEMPDSNS 1694
                                                ||.:|:.::                 .||
 Worm  1362 ------------------------------------GGALSSSRS-----------------HNS 1373

  Fly  1695 LVDSVPPQPPAPTAQPLSSNTQQ---PKSILKHNRYSEGGVGPSGAPSSPSKSQKSASFADERHL 1756
            |     .|.||...:|:..|..:   |.||       .|.|     |::.:::.:.........|
 Worm  1374 L-----SQEPAIVIRPVDLNMPKATPPASI-------RGAV-----PTAITQALQLQPNGGGAVL 1421

  Fly  1757 HTEHPISNLAKELNQLTM--LDKDNN--------NETLDAVVPPPPPPERNSSYLIMSQQKLRGS 1811
            ....|.|.|.:.|....:  |:|.|.        ||.||.:       :...:.:.:.:|:....
 Worm  1422 RQVRPASGLRERLQDADVRNLEKTNTALMSYEAVNEELDRL-------DAKQNTMTIDEQRRYRE 1479

  Fly  1812 TGNATSSMGLLKTATSNQAAAAVEIKKASL-LNTQTNNNNNLSGSLNNNTMHGSPLSAMELNAAY 1875
            ..|..:.....:...|...:.....::..: ::.|.....:...::.::..|.|  |::|     
 Worm  1480 LLNVVAEQSRARKLLSEIRSPPTSYQEREIPIHVQKEQQQHRRETVIDDIPHSS--SSVE----- 1537

  Fly  1876 VSATGTGIIGGLGTPPPPPPLMQRDNKRVSFHDEENNFVSGNSQQQQLQQQYIMDNYGMEHQDLD 1940
                        ...|..||    ::::|.|.||              ..||.....|..|...|
 Worm  1538 ------------NVSPVSPP----ESRKVQFIDE--------------VVQYQTPTSGANHAFFD 1572

  Fly  1941 TIREDTSYLQHNLDASMLPSMPATPDAALWNTSVQSTPGVIGAQEVYRDPRTRRLAEKQQQQQQQ 2005
            .:                              .|..:||::|..|:|||||.|||.|.|.:.:..
 Worm  1573 DV------------------------------PVLDSPGIVGTNEIYRDPRQRRLNELQDRNRSS 1607

  Fly  2006 RAGDAVPEKLSFKEKMKMFALESGEDKTPKDKLKISRAQRDID 2048
            ..|.|...||.|::|.::||.:.|||..|:.::..|.|||.|:
 Worm  1608 ENGAADGAKLGFRDKQRLFARQIGEDTAPRQRMNESSAQRLIE 1650

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cnoNP_001303494.1 AF6_RA_repeat1 20..131 CDD:176377 74/123 (60%)
AF6_RA_repeat2 257..346 CDD:176376 31/105 (30%)
FHA 398..461 CDD:278899 29/68 (43%)
Myo5p-like_CBD_afadin 631..941 CDD:271255 103/333 (31%)
DegQ <983..1112 CDD:223343 57/154 (37%)
PDZ 1009..1097 CDD:214570 45/87 (52%)
afd-1NP_001021660.2 RA1_Afadin 15..126 CDD:340480 74/110 (67%)
RA 221..321 CDD:366305 30/103 (29%)
FHA 354..457 CDD:238017 39/145 (27%)
Myo5p-like_CBD_afadin 566..867 CDD:271255 103/328 (31%)
PDZ_signaling 973..1054 CDD:238492 43/80 (54%)
DUF3295 <1174..>1240 CDD:371678 11/80 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160166570
Domainoid 1 1.000 130 1.000 Domainoid score I3254
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 573 1.000 Inparanoid score I569
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006109
OrthoInspector 1 1.000 - - oto20299
orthoMCL 1 0.900 - - OOG6_105992
Panther 1 1.100 - - LDO PTHR10398
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2286
SonicParanoid 1 1.000 - - X5048
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1010.010

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