DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cno and afdn

DIOPT Version :9

Sequence 1:NP_001303494.1 Gene:cno / 40620 FlyBaseID:FBgn0259212 Length:2051 Species:Drosophila melanogaster
Sequence 2:XP_031758152.1 Gene:afdn / 100493083 XenbaseID:XB-GENE-948333 Length:1902 Species:Xenopus tropicalis


Alignment Length:2193 Identity:728/2193 - (33%)
Similarity:1068/2193 - (48%) Gaps:457/2193 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 DREAVRSVIQQWNANRLDLFALSEPDENLLFHGVMRFYFQD-AGQKVATKCIRVASDATVTDVID 72
            :|..:..:|..|||||||||.:|:|.|:|.||||||||||| |....|||||||:|.||..|||:
 Frog     8 ERRKLADIINHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIE 72

  Fly    73 TLIEKFRPDMRMLSVPNYALYEVHANGEERRLNADEKPLLVQLNWHIDDREGRFLLKNID----- 132
            ||.|||||||||||.|.|:|||||.:||||:|:.:||||:|||||:.|||||||:|||.:     
 Frog    73 TLAEKFRPDMRMLSSPRYSLYEVHVSGEERKLDFEEKPLVVQLNWNKDDREGRFVLKNENDIFPA 137

  Fly   133 ---QKTTPIEQTD----LNFKRKLSKREKKEQKKKEK-MAKLSSDPPTSNGSHLGLGNGVGASSG 189
               |...|.:|..    .||||.|||:||||:|::|: :.|.|:|                    
 Frog   138 KKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKRRERDILKQSTD-------------------- 182

  Fly   190 SAHMNGNAGGTGGDSSD-AVAGKLYTELPETSFTRSISNPEAVMRRRRQQKLEKKLQQFRSRDGG 253
                |.:......||.: .:|.::|.::|||||||:|||||.||:|||||||||::|:|||.||.
 Frog   183 ----NEDRPQVRDDSENLQLAMEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGR 243

  Fly   254 PDTGGTLKIYGESLCQDVPYKTLLLSIRDCAQAVVREMLTKYGLEKADPLHYCLVQV-------N 311
            ||:||||:||.:||..::||||:|||..|.|...|.|.|.|||:||.:|..||:.:|       :
 Frog   244 PDSGGTLRIYADSLKPNIPYKTILLSTNDTADFAVIEALEKYGMEKENPKEYCIAKVVLPPGAQH 308

  Fly   312 SDG--TEYILDDDECPLSILMNHPTSRGSIMFHVRRRPADS---QPRRRKKKPLGAANGANH--- 368
            ||.  .|:||||:||||.|..:.|:.:|.::|.::|||.||   |.|:.:.|...:....:|   
 Frog   309 SDKGMKEFILDDEECPLHIFRDWPSEKGELVFQLKRRPTDSLLKQNRKHESKSGKSKERGDHYSL 373

  Fly   369 -ISGDREGPVLVEVTHSG----DGGRRIKLGSDPVEVGSA--NTNCLQLFGPSIQPRHCLISLLE 426
             :|.|:. |.|||::..|    |..:..:|.....|||:.  ..|.:|||||.||..||.::.::
 Frog   374 SLSPDKL-PYLVELSADGSDSRDKPKLYRLQPSVTEVGTEKFQDNSIQLFGPGIQHHHCDLNNMD 437

  Fly   427 GVCTVTPLHTDALTFVNGHHISQPTILHNGSVVMFGRVASYRFLDSPTDGRYNLALSQSQLDSAC 491
            ||.||||...||.|:|:||.||:.|:||:|..|.||....::|:|.      ||           
 Frog   438 GVVTVTPRSIDADTYVDGHRISETTMLHSGVTVQFGSSHVFKFVDP------NL----------- 485

  Fly   492 LYESRSPTSPGSWNDEDGALSSTHKSDYDHHQQANHSSAYHNNNNNSSDHPLSSTLRDVVDSKAG 556
                                                            ||.|...|.|.  .:.|
 Frog   486 ------------------------------------------------DHLLGKRLSDA--GQIG 500

  Fly   557 QDQGANSGNYDGQ-SLEGNLENE-----TKSISSLKSGGSNSQDRSPKMTGSGILAG-------- 607
            ::|.:..|..:.. .|||.:..:     .|.:|.|      ..||:|.||..|::..        
 Frog   501 KNQRSKQGLQETTFGLEGEVLGDVTLPVNKMVSKL------DNDRTPGMTERGMVKPIIRMDKQQ 559

  Fly   608 ----GGSGSGDTQGQEPILPAVLEFPETHQELFLRHIISELDVNVPHFKLAPVYSLYLCARYRAS 668
                ....|.|:||.|.:|||.:||.|..::.||..||:..:.:..||||:|.|.||:..||..|
 Frog   560 DQRVQNGRSQDSQGPENVLPANIEFRENSEDAFLSAIINYTNSSTVHFKLSPTYVLYMTCRYVLS 624

  Fly   669 THYRPELQPTERAHKLTMFLHHVANLVYSVVQE-------QYTDPRILAFWMANSSEFLHFLKSD 726
            ..|||:..|.||.||:...::.:..::.||:||       |......|||||||:||.|:|:|.|
 Frog   625 NKYRPDTSPAERTHKVIAVVNKMVGMMESVIQEIDKGNQKQKNIAGALAFWMANASELLNFIKQD 689

  Fly   727 RHISAFSVQAQEVLAEAVQTAFRNLVNCFRLELSQTLNQFLSENIDHDSAAGL---VLTVLGSAM 788
            |.::..::.||:|||..||.||:.||:|.:.||:.::..|:.:..::||....   ||..|..||
 Frog   690 RDLNRITLDAQDVLAHLVQMAFKYLVHCLQSELTSSMPAFIDDPEENDSQRPKIEDVLHTLTGAM 754

  Fly   789 ALLRRCRVNAALTIQLFSQLFHYINVICFNTIVA--NSQMCTGDWGKVMTERLQLLELWAERQGL 851
            :|||||||||||||||||||||:||:..||.:|.  :|.:|:..||.::.::|..:|.|||:|||
 Frog   755 SLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLAHIEAWAEKQGL 819

  Fly   852 ELAADCHLAKINQCAQFLQAPKSSVEEIQQLACSCFRLNSLQMAALLQ-------QEKLPRNLVD 909
            ||||||||::|.|....|...|.|.::|..:..:||:|||||:.||||       :..:|..|:|
 Frog   820 ELAADCHLSRIVQATTLLTMDKYSHQDIPNINNTCFKLNSLQLQALLQNYHCAPDEPYIPTELID 884

  Fly   910 TAIRMAESVADELTRADGREVRLEESPELHLALLLPDDGFSCDVVRGIPTGLVDFLNPLQQQGMC 974
            :.:.:||:.||||.|:|||||:|||.|:|.|..|||:||:||||||.||.||.:||.||.|:|.|
 Frog   885 SVVSVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLEPLCQRGFC 949

  Fly   975 RLAAQPTSIGLWTVYMHQFNARSSSAMSN-KLP---QPELQLIKLHKNSNGMGLSIVAAKGAGQE 1035
            ||.....|.|:||:|.......::....| .||   :||:..:.| |..||||||||||||||||
 Frog   950 RLVPHSRSPGMWTIYFEGAEFENNLLTDNTDLPLRKEPEIITVTL-KKQNGMGLSIVAAKGAGQE 1013

  Fly  1036 KLGIYIKSVVPGGAADADGRLQAGDQLLRVDGQSLIGITQERAADYLVRTGPVVSLEVAKQGAIY 1100
            ||||||||||.||||:.||||.|||||:.||||||:|::|||||:.:.|||.||:||||||||||
 Frog  1014 KLGIYIKSVVKGGAAEVDGRLAAGDQLISVDGQSLVGLSQERAAELMTRTGAVVTLEVAKQGAIY 1078

  Fly  1101 HGLATLLQQPSPVIQRGNRRMSERDLTRMGGAESTKSLGPLIANNHPNHSLSLSQHLNNSHNNTL 1165
            |||||||.||||::|| :||.|        |....||.|..:.||                    
 Frog  1079 HGLATLLNQPSPLMQR-DRRGS--------GKPRPKSEGFELYNN-------------------- 1114

  Fly  1166 GNSNNSSIINPLA--AHLPNSKSVPALHHHTGSGTISLANSKSRSTHSLHNNTSGMGGIGGAAAG 1228
             .|.|.|..:|..  ......|.:|      |...:....:..||:.::.|...        :.|
 Frog  1115 -ASQNGSPDSPQTQWPEYTEPKKLP------GDDKLMKNRADHRSSPNVANQPQ--------SPG 1164

  Fly  1229 GMLGQPNGSQNNANGNGNGNEQGFYQNLSVYRAQNQSQPILNERPPIAAHAAMNAY------NGS 1287
            |.....:.|.........||          ...:.|:.|...|..||........|      ...
 Frog  1165 GKTTYSSSSTVKITSVSTGN----------LCTEEQTAPARPEAYPIPTQTYAREYFTFPTPKSQ 1219

  Fly  1288 SPLAPQQQPQQQQQSPYQQQQQQQHMQANANLPPTRPVSAYYHSQQSAQQQLQQQQQQQQQHSLQ 1352
            ..:.|.|...|..:..:|.|....|.:                 ..||||....:::.:...:.|
 Frog  1220 DRIGPAQNQWQGYEDNFQVQMGNNHAR-----------------NTSAQQVAYSEEELRDNLTFQ 1267

  Fly  1353 QQQFALSSGNLNGQQQQQQQHQHQHQLTLNNRTKSQQNFQHTLRMQQMMAPSMPNISNM------ 1411
            .::     |.:..|.::..:|...:. |..||..|.::......:......|:.::|..      
 Frog  1268 SER-----GRVEPQVRKDVEHLDGND-TWFNRGSSMESSASCQDLNNSKTHSVGSLSKTGPGRWK 1326

  Fly  1412 ---------------------------YHHQQQQQQ---QLPLQQQQQQQQQPLMSSSQSMQNVN 1446
                                       .|:..:.:.   .|||.....:.|..|.::||:     
 Frog  1327 TPISSQSATVLLPQPVRTDLPPPPPPPVHYGAEFEGVPIDLPLPPPPSESQLGLSTNSQA----- 1386

  Fly  1447 DFAGGYQNGSLEYRRSQLHDPSTLYEIQQQQLQQQQQQQQQQQQQQ--QASPNFIALPPKPLGSL 1509
                    .:||.::.:.|  ...||.::.:|::::::::::|:::  |..|....:||:|:.. 
 Frog  1387 --------AALERKKREEH--QRWYEKEKARLEEERERKRREQERKLGQVRPQPPTIPPQPVNP- 1440

  Fly  1510 QSPNKPNVPPSTAPKPQQDKPPLPPTATHPLFKATQ-QIAPGMNYVASTLDPPKGSYVASNQGNN 1573
            |||  |.:||....:.:.:||...|.....:.:..| |..|      .|::.....|:..::...
 Frog  1441 QSP--PLIPPPNVAQARTEKPATLPRQQETVIRELQPQQQP------RTIERRDLQYITVSKEEL 1497

  Fly  1574 RPLHSGS-NPWEREEREKDLEMRREHIRQWREQQISELSQIVSRSPMQEEQLKTLILERDFERRA 1637
            ....|.| :||:|:.:||..:.::.||.....::|:||.....|:..:.::|:.|:||..|::|.
 Frog  1498 SSSDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEINELQNKPDRTSEENDRLRKLMLEWQFQKRL 1562

  Fly  1638 QELQEQEEQDQEQQYDKENVQELF---RLAGGGQVSAIQTPITSYRQTEIKLAEMPDSNSLVDSV 1699
            ||.|::::.|.:...|.::|..:.   ||....:.          |||     .|| :.|::|.:
 Frog  1563 QESQQKDDDDDDDDDDDDDVDTMLIMQRLEAERKA----------RQT-----AMP-AISILDLL 1611

  Fly  1700 PPQPPAPTAQPLSSNTQQPKSILK---HNRYSEGGVGPSGAPSSPSKSQKSASFADERHLHTEHP 1761
            ..:..........:..::.:..|:   .:|:.|              .:::...|:|:....|..
 Frog  1612 QDEERRRQQHLEEARKREAEDRLRQEEEHRHQE--------------EERARREAEEKRRQEEEY 1662

  Fly  1762 ISNLAKELNQL------TMLDKDN--------------NNETLDAVVPPPPPPERNSSYLIMSQQ 1806
            .:.|..|..::      .:||.:.              ::.||.. .||||||:||:||      
 Frog  1663 YNRLEAERRRIHEEAERRLLDPEEPGLYRPPLPREYELSSPTLPP-NPPPPPPQRNTSY------ 1720

  Fly  1807 KLRGSTGNATSSMGLLKTATSNQAAAAVEIKKASLLN-TQTNNNNNLSGSLNNNTMHGSPLSAME 1870
                           |||    ||.:...:..|..:. |....:.||||....::|..|      
 Frog  1721 ---------------LKT----QALSPDTVYTAKFVTYTDDEEDTNLSGQDKYSSMRKS------ 1760

  Fly  1871 LNAAYVSATGTGIIGGLGTPPPPPPLMQRDNKRVSFHDEENNFVSGNSQQQQLQQQYIMDNYGME 1935
                            .|..||.....|....|:.....:..|:||:.|.............|  
 Frog  1761 ----------------YGDLPPAAHKPQLPAARLPRPVSDGIFLSGSFQPPSANANSTASKTG-- 1807

  Fly  1936 HQDLDTIREDTSYLQHNLDASMLPSMPATPDAALWNTSVQSTPGVIGAQEVYRDPRTRRLAEKQQ 2000
                ..|....|:|.::  :|..|           |:...|:...:...|||:|||..||  |.|
 Frog  1808 ----PPIANKPSFLHYS--SSKGP-----------NSYSGSSGAAVPGNEVYKDPRDVRL--KSQ 1853

  Fly  2001 QQQQQRAGDAVPEKLSFKEKMKMFALESGEDKTPKDKLKISRAQRDID 2048
            ..:....|.| ||.|:|||:.::|:  .|:|.:  :|:|.||...:::
 Frog  1854 DGEAYSTGGA-PESLTFKERQRLFS--QGQDVS--NKVKASRKLMELE 1896

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cnoNP_001303494.1 AF6_RA_repeat1 20..131 CDD:176377 81/111 (73%)
AF6_RA_repeat2 257..346 CDD:176376 44/97 (45%)
FHA 398..461 CDD:278899 32/64 (50%)
Myo5p-like_CBD_afadin 631..941 CDD:271255 147/328 (45%)
DegQ <983..1112 CDD:223343 86/132 (65%)
PDZ 1009..1097 CDD:214570 64/87 (74%)
afdnXP_031758152.1 RA1_Afadin 19..131 CDD:340480 81/111 (73%)
RA2_Afadin 247..346 CDD:340479 45/98 (46%)
FHA 380..480 CDD:238017 41/100 (41%)
Myo5p-like_CBD_afadin 587..916 CDD:271255 147/328 (45%)
PDZ 990..1072 CDD:395476 60/82 (73%)
DUF4659 1527..>1633 CDD:406094 25/121 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 171 1.000 Domainoid score I3717
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1026 1.000 Inparanoid score I280
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006109
OrthoInspector 1 1.000 - - oto104335
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5048
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.050

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